DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and A2M

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_006719119.1	Gene:	A2M / 2	HGNCID:	7	Length:	1512	Species:	Homo sapiens

Alignment Length:	1517	Identity:	387/1517 - (25%)
Similarity:	644/1517 - (42%)	Gaps:	241/1517 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSTILHCVLL---SNANG--LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKY 66
            |..:|..|||   ::.:|  .|.||.|..|.:.:.....|.:.....|..||.||.....|...:
Human    10 SLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLF 74

  Fly    67 VDVQSMSS--KSVRFDIPKLTEGD--YELKVMGSGGI-EFQNSTKLSFAPDLNWLYIQSDKATYK 126
            .|:::.:.  ..|.|.:||.:..:  ..|.|...|.. ||:..|.:....:.:.:::|:||:.||
Human    75 TDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYK 139

  Fly   127 PGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNW 191
            ||..::|||:.:|:|..|.....|: :.|:|...|.|..|:..:...|:......||..|..|::
Human   140 PGQTVKFRVVSMDENFHPLNELIPL-VYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSY 203

  Fly   192 TVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATI 256
            .|....:..|:..:...|:::|:|||||.|...|.:......:..::...||:.|||.|||..:|
Human   204 KVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSI 268

  Fly   257 ----------EGSSTEQSL-PIDGEVN--------VEFPISATAKR----LLKITAIVTEELTDI 298
                      .|..::... ...|::|        |:..:....::    .|...|.:.||.|.:
Human   269 CRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVV 333

  Fly   299 KHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKN 363
            :..|.....:.:...||..:...:|:|.|:  .|...||.:||..|...:|::       .:..|
Human   334 ELTGRQSSEITRTITKLSFVKVDSHFRQGI--PFFGQVRLVDGKGVPIPNKVI-------FIRGN 389

  Fly   364 FSASLQNSIATEHIMLPETCQSCLVTSTFDTA--------------------ENIERYIYKLNKP 408
            .:....|:...||.::..:..:..|..|..|.                    |......|.:..|
Human   390 EANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSP 454

  Fly   409 LMIAI------------NTKKPQLRKLLKINIISDTYLPYFILTVVARGNIVLS----LFQEMKE 457
            ....:            :|:..|...:|....:.......|...::|:|.||.:    |..:.::
Human   455 SKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQED 519

  Fly   458 KKKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVS 520
            .|....|.......:.|.|.:.::.:: .|.::.|....|:|....|.::: .:.:::||.....
Human   520 MKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAH 584

  Fly   521 LKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATY-------------STDLVILTNAN 572
            |:|...|.|...|..|||||||::...:|:...:.|.|...             :.|.:...|..
Human   585 LRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNEDCINRHNVY 649

  Fly   573 INIYRSSGGCYTNPGYTNCTGSL-----IGRTMFKNEPTKNSGPVP------------------- 613
            ||     |..||....||.....     :|...|.|...:.....|
Human   650 IN-----GITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYE 709

  Fly   614 --IVGSTRAQASL--------PPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFS 668
              ::|  |..|.|        ..|||.|||||:: ::..|.:.|...:..|||||:|.|....|.
Human   710 SDVMG--RGHARLVHVEEPHTETVRKYFPETWIW-DLVVVNSAGVAEVGVTVPDTITEWKAGAFC 771

  Fly   669 LSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQY 733
            ||..:||.::...| :|.|||||:...:||||.|||...:...|.|||...::..|.::.|..
Human   772 LSEDAGLGISSTAS-LRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPA-- 833

  Fly   734 EFIET-TNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITA----ISKYAGDRL 793
             |:.. ..|..:.:.          |.||..:.:|:.:.||.:|.....::|    ..:..|.
Human   834 -FLAVPVEKEQAPHC----------ICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGT-- 885

  Fly   794 HQILKVEADGVQKYVNKAVLINVQRLNRRS-----LAPP----EKTIIIEKADNVIEGSETVEFE 849
             ::..|...|.:..|.|.:|:..:.|.:.:     |.|.    .:.:.::...||:|.|......
Human   886 -EVPSVPEHGRKDTVIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVS 949

  Fly   850 VCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQI 914
            |.|......:::..:|:.:|.|||||||..|.|:|..|.||....:...||::||..|:.||||.
Human   950 VLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQR 1014

  Fly   915 ELNYKRNDGSFSAWGQHDA--LGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGK 977
            :||||..|||:|.:|:...  .|:|||||:|:::|.||..||.||:..:...|.:|..||..:|.
Human  1015 QLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGC 1079

  Fly   978 FKELGMVIHNS-HG---SPLALTSFVLLTFFENEEYMP-KYKHVIDRAVEF-------VVTEVHQ 1030
            |:..|.:::|: .|   ..:.|::::.:...|    :| ...|.:.|...|       ...|...
Human  1080 FRSSGSLLNNAIKGGVEDEVTLSAYITIALLE----IPLTVTHPVVRNALFCLESAWKTAQEGDH 1140

  Fly  1031 SNEPYDLAIAALALSLARNRNAYK-VLDKLDKLATRRGDHKWWTGSDKCK------------SSE 1082
            .:..|..|:.|.|.:||.|::..| ||..|::.|.::.:...|....|.|            |:|
Human  1141 GSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAE 1205

  Fly  1083 VETTSYVLLALLEHNISDEPKP----------IVDWLISKRNSNGGFVSSQDTVVGIMALTKYEL 1137
            ||.|||||||.|    :.:|.|          ||.|:..::|:.|||.|:|||||.:.||:||..
Human  1206 VEMTSYVLLAYL----TAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGA 1266

  Fly  1138 QSHAST-EAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYN 1201
            .:...| :|..:............:|...|...:|...|||...|..:...|:|...:|.:.:||
Human  1267 ATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYN 1331

  Fly  1202 VATKEARPSFKL-------TTTVKKSHKG-RLILGICGTYTPIAASERNKTTNMALMQVQLPSGY 1258
            :..::....|.|       |....|:|.. ::.|.:  :||     .....:|||::.|::.||:
Human  1332 ILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSV--SYT-----GSRSASNMAIVDVKMVSGF 1389

  Fly  1259 VCDIEPFAD-IEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYT----HAVANLKPSW 1318
            : .::|... :|..:.|.|.|..:  ..|.||.:|:|.     .||...:|    ..|.:|||:.
Human  1390 I-PLKPTVKMLERSNHVSRTEVSS--NHVLIYLDKVSN-----QTLSLFFTVLQDVPVRDLKPAI 1446

  Fly  1319 VRLYDYYATERSATEFYHVDTS 1340
            |::||||.|:..|...|:...|
Human  1447 VKVYDYYETDEFAIAEYNAPCS 1468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	25/84 (30%)
		A2M_N_2	411..542	CDD:285005	30/148 (20%)
		A2M	634..726	CDD:278630	35/91 (38%)
		A2M_2	859..1135	CDD:239227	107/312 (34%)
		A2M_comp	910..1135	CDD:284982	87/261 (33%)
		A2M_recep	1245..1335	CDD:284981	30/94 (32%)
A2M	XP_006719119.1	YfaS	<124..>1071	CDD:225248	243/981 (25%)
		A2M_N	129..221	CDD:280081	26/92 (28%)
		A2M_N_2	461..606	CDD:285005	30/144 (21%)
		A2M	738..828	CDD:278630	35/91 (38%)
		A2M_2	958..1264	CDD:239227	107/313 (34%)
		A2M_comp	1010..1266	CDD:284982	89/263 (34%)
		A2M_recep	1376..1463	CDD:284981	30/94 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149966
Domainoid	1	1.000	84	1.000	Domainoid score	I8230
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650