Protein Alignment Tep1 and F13D2.1

DIOPT Version :9

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001263970.1
• Gene: F13D2.1 / 181305
• WormBaseID: WBGene00008735
• Length: 1659
• Species: Caenorhabditis elegans
• Alignment Length: 1571
• Identity: 299/1571 - (19%)
• Similarity: 547/1571 - (34%)
• Gaps: 469/1571 - (29%)

  Fly    38 NVVVAIHNTTRTTEVSVSLTGPSLN-----SRKYVDVQSMSSKSVRFDIPKLTEGDYELKVMGSG 97
            ||:..::..:..|.|.:...|...|     ..:.:...:.||:|....:.|: :|:.||.
 Worm    34 NVITIVNEKSVKTVVQIDHGGEKTNKEIQGEHQIISFHTSSSQSFAHIVIKV-DGEVELD----- 92

  Fly    98 GIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNL 162
                ||   :...|||..::|..|||.|:..:.:..|:|.|..:  .::....:.|.:.:| :..
 Worm    93 ----QN---VPVRPDLFNVHIHIDKAVYRKSELVNVRILPLTHS--GSIYRGDLSITLVNG-KGF 147

  Fly   163 IKS----WKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEG--KVTNVLVVDK------YVVP 215
            ::|    .|.::....:.|.:|::......|:|.:.....:.|  |:..:||.:|      |.:|
 Worm   148 VESSTMRVKRVEETDSMISDQLEIPSHTFFGDWFLKVQPVEYGSKKIDEMLVFEKTFQVQDYDLP 212

  Fly   216 KFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKG--HVVATIEGSSTEQSLPIDGEVNVEFP-- 276
            .:.:......|  :.......|::|:|...|||.|  ||.....|||::....:....:.||.
 Worm   213 NYRLNGFLVDN--SDLDKTTVTVEAKYFHGKPVNGSVHVYCREVGSSSQDRSHLTHLRSGEFDNG 275

  Fly   277 ISATAKRLLKI---TAIVTEELTDIKHNGTAYVTVHQHRHKLEDL----------FWPTHYRPGV 328
            |.::...|.|.   ..:..|...:.:.|||.|         .:||          |..|..||..
 Worm   276 IWSSIVDLGKCDPPNPLPKEIYIESRENGTGY---------RQDLILGLDVMAPKFTITAVRPYF 331

  Fly   329 SSEFKTVVRNLDGSPVMDSSKMVNFNVLC------------CQVSKNFSASL--------QNSIA 373
            :::.:.::..:||..:...:  |:..:.|            .:|......:|        ||.::
 Worm   332 TNDVEEIILLVDGDGIAHGN--VSIRIECISEKNDVMRTKEVKVGSKIGDALKIGIPKEWQNDVS 394

  Fly   374 TEHIM----------------LPETCQSCLVTSTFDTAENIERYIYKLNKPLMIAI-NTKKPQLR 421
            ...::                :|....:.||:|.. :.|.|:.: ||.::.:.:.: ||:|
 Worm   395 VIRVIANRRIKNGFSNDTMLYIPNLSNTSLVSSLI-SPEEIKPF-YKDDEIMNVHVKNTRK---- 453

  Fly   422 KLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI--EFEPTFALVPQATIFV--HY 482
               :.|.:           ::...:.|..:..|:|.:....:|  :.|.|..|    |.|.  ..
 Worm   454 ---ETNFV-----------IICNSHTVHRVPNEVKNRILRVKITDKMEGTCIL----TAFTADSS 500

  Fly   483 IIDGVLM-----SDEKTVDIERDFENTIEILTTNEAL-PRDEVSLKVKTNPHSFVGLLGVDQSVL 541
            :.|.:|.     .::..|.:.:......:.|..|:|: |.|.:.|:...:..:.|....:|:.:.
 Worm   501 VSDVMLFRVQTHCEDCKVKVSKVLNGMSKELGNNDAIEPGDVMELEFTGHSEAIVFYRAMDERLN 565

  Fly   542 LLRSGNDL----NRDLILNNLATYSTDLVILTNAN---------------------INIYRSSG- 580
            .:...||.    ..|.::....:....::.|.||.                     :...||:.
 Worm   566 YITLRNDYMIHEYLDYLIFGKQSQGAKILNLVNAEKVEHAMKKMCTSAGHQLRFRCLQGQRSTSL 630

  Fly   581 -----------GCYTNPGYTN---CTGSLIGRT----------------MFKNEPTKNSGPV--- 612
                       .||.|...|.   .|..|.|:|                :|:::..|  .|:
 Worm   631 VSEKCLKHVLKSCYKNSSATAMQIVTPYLSGKTTPVLSASSTNWLDNINVFRSKSMK--APLQLF 693

  Fly   613 -------PIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITG---- 666
                   |.|.|.:::     :|:.|||||||..|. :..||...|..|.||.:..|.:..
 Worm   694 VKPEFHDPGVVSQKSR-----IRQHFPETWLFDAIV-LERNGTKKITATSPDNVGQWALNNAYWW 752

  Fly   667 ---FSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMD-VKA----- 722
               .||.|       .....|:..:..|:..::|.:|...|.|: |::...  |:| ||:
 Worm   753 HGRVSLYP-------GQTKYIQTSKAIFLEVDMPRNVYVNETIS-PLLTIT--GVDLVKSRETLV 807

  Fly   723 --------KVLMD------NSDGQYEFIETTNKN--VSQYLRGVRRKKTLWIPANTGRGISFMIR 771
                    ||..|      ..|..|..:|.:..:  .|:||                     |::
 Worm   808 ICLSELPRKVCADQGANGKKGDTYYMKVEVSRSSPIQSKYL---------------------MMK 851

  Fly   772 PKKVGLTTLKITAISKYAGDRLHQILKVE-------ADGVQKYVNKAVLINVQRLNRRSLAPPEK 829
            ....|:..:.:|             ||.|       .|.|:|.:......:.:....|.:..|.|
 Worm   852 FLSPGVVNMTLT-------------LKTENCQTGKILDAVRKQIEIQKRADTEEYYERHILNPSK 903

  Fly   830 TIIIEKADN-------------------VIEGSETVEFEVCGTSQAPQLEHL------------- 862
            .::....|:                   .::.::|:...:  ||..|..|.:
 Worm   904 PLVTAMNDDPGSTSSRNTKMITFSDQHGSMDEADTINTLI--TSNVPDTETVFSFSITLSKFLPI 966

  Fly   863 -DDLVHLPCGC----GEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNY---- 918
             |.:..:|.|.    ..|.:...|...|::...|.|         |.|.|..|.||:|...
 Worm   967 TDKIGKIPIGTRSKRNGQRILTSVIKELSIVLYKFK---------KLKLYGSTSYQMEAEINDLI 1022

  Fly   919 -----------KRNDGSFSAWGQHDAL--GSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVS 970
                       ::...::|.:|:..|.  .|..||:.......:|    |:::|.::..|..:.:
 Worm  1023 NEMMQFSNCTSQKEPCAYSEFGKPQASNEASILLTSIATSLLCEA----DVEENRILGSLKTITA 1083

  Fly   971 RQSTDGK--FKE-LGMVI--HNSHGSPLALTSFVLLTFFENEEY-------------MPKYKHVI 1017
            .....|:  |.| |..:|  .|:......|.||:.....:...|             :.||.:.:
 Worm  1084 YIPKLGRKDFNEDLSDIIDVENTEDKKYLLVSFMYQVSRDCSSYRSGLRDMTKSFGKLHKYFYEL 1148

  Fly  1018 DR----------AVEFVVT-------------EVHQSNEPYDLAIAALALSLARNRNAYKVLDKL 1059
            |.          |:.|:.|             |:::.:.||            ...|.|.. :::
 Worm  1149 DESAVQDRRTSAAIAFMATNATAELMRSDLIAEINKEHPPY------------WKCNGYDT-NRV 1200

  Fly  1060 DKLATRRGDHKWWTGSDKCKSSEVETTSYVLLALL----EHNISDEPKPIVDWLISKRNSNGGFV 1120
            |||  :|....:....:.|   :|...|:.|.|::    |....|..: :.||:..:::|:|.:.
 Worm  1201 DKL--KRSSESFRRRRESC---QVMVNSFALAAIVTAYAEGTEVDWDR-LADWISEQQSSDGSYG 1259

  Fly  1121 SSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNE--------DKKHVRVTKENEFKVQTHQLPE 1177
            |...|:|...:|.:      .|..:::|.:..|.|        .:|.:.||   |..::.| :|.
 Worm  1260 SPLTTLVASRSLFE------KSRRSVEIAYNDLLEVTVRCKGCSEKRINVT---ESAIEIH-IPN 1314

  Fly  1178 NTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTYTPIAASERN 1242
            |.:.|.|:.||.|:|.|....   ||||..||...||.               ..|.|:..|...
 Worm  1315 NIHYVTLITKGHGKAVVAARI---VATKRPRPKRGLTQ---------------DDYYPVHLSIDQ 1361

  Fly  1243 KTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKNEDTEVHIYF-----EKLSPGDRKCLT 1302
            |..:..:.|.      ||.......|:.:.......|....|...:||     ..::|.. ..|.
 Worm  1362 KVQDNFVHQT------VCFNVSNPTIKTLDIFHGTYTLFTATPDQLYFLNDSYTPINPSS-SALG 1419

  Fly  1303 LEAIYTHAVAN 1313
            |..|.|:.|:|
 Worm  1420 LHFIITNIVSN 1430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	16/88 (18%)
		A2M_N_2	411..542	CDD:285005	24/141 (17%)
		A2M	634..726	CDD:278630	28/112 (25%)
		A2M_2	859..1135	CDD:239227	66/355 (19%)
		A2M_comp	910..1135	CDD:284982	54/286 (19%)
		A2M_recep	1245..1335	CDD:284981	15/74 (20%)
F13D2.1	NP_001263970.1	MG3	204..>261	CDD:375334	15/58 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100