DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and Mug2

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_006505762.1	Gene:	Mug2 / 17837	MGIID:	99836	Length:	1490	Species:	Mus musculus

Alignment Length:	1519	Identity:	381/1519 - (25%)
Similarity:	660/1519 - (43%)	Gaps:	258/1519 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LHCVLLS--------NANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYV 67
            |..|||:        |.:..|.||.|..|.:.:...:.:.:::...|..|:.||...: ..|...
Mouse    11 LFSVLLAFLPSASSLNGDSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLVSQT-GRRNLF 74

  Fly    68 D---VQSMSSKSVRFDIPKLTEGDYE--LKVMGSGGI-EFQNSTKLSFAPDLNWLYIQSDKATYK 126
            |   |.....:.|.|.||.|...|.|  |.|...|.. ||.....:......:.:::|:||..||
Mouse    75 DELVVDKDLFQCVSFIIPTLNSPDEEEFLYVDIKGPTHEFSKRNAVLVKNKESVVFVQTDKPVYK 139

  Fly   127 PGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNW 191
            ||..::|||:.:||..||.....|:.. |.|..:|.|..|:|||...|:......|:..|:.|.:
Mouse   140 PGQSVKFRVVSMDKTLRPLNELLPLAY-IEDPKKNRIMQWRDIKTENGLKQMSFSLAAEPIQGPY 203

  Fly   192 TVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATI 256
            .:....|...|..:...|.::|:|:|.|.:.....::.:...::.|:..:||:.|||.|.|..:|
Mouse   204 KIVVHKQSGVKEEHSFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCGKYTYGKPVPGQVKISI 268

  Fly   257 ----EGSSTEQSLPIDG------EVNVEFPISATAKR------LLKITAIVTEELTDIKHNGTAY 305
                |....|.:..:|.      |||:   ....:|:      |..:.|.||||.|.::.||...
Mouse   269 CHETEAGCKEVNSKLDNNGCSTQEVNI---TELQSKKRNYEVQLFHVNATVTEEGTGLEFNGYGT 330

  Fly   306 VTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASL-- 368
            ..:.:..:||..|...:|:|.|:....|..:.::.|.|:.:....:...||      .::::.
Mouse   331 TKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVL------GYTSATTT 389

  Fly   369 -QNSIA------------TEHIML----PETCQ--SCLVTSTFDTAENIERYIYKLNKPLMIAIN 414
             |:.:|            :.||.:    .::|.  .|: ...:.:||::...:|.|:|..:..:.
Mouse   390 DQHGLAKFSIDTAGFSGSSLHIKVNHKGKDSCYFFYCM-EERYASAEHVAYAVYSLSKSYIYLVK 453

  Fly   415 TKKP----------QLRKLLK--INIISDTYLPYFIL---TVVARGNIVLSLFQEMKEKKKSQEI 464
            ....          |...:||  :.::.:....|.::   :::..||....:.......|.:.::
Mouse   454 ETSSILPCNQIHTVQAHFILKGDLGVLKELVFYYLVMAQGSIIQTGNHTHQVEPGEAPVKGNFDL 518

  Fly   465 EFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLKVKTNP 527
            |....|::.|.|.:.::.|: ||.:::|....:||:...|.::: .:::::||..:..|:|..:|
Mouse   519 EIPVEFSMAPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLSFSSSQSLPASQTRLQVTASP 583

  Fly   528 HSFVGLLGVDQSVLLLRSGNDLNRDLILN--------------------NLATYST--------- 563
            .|..||..||||||||:..::|:...|.|                    :...||:
Mouse   584 QSLCGLRAVDQSVLLLKPEDELSPSWIYNLPGMQHNKFIPSSSLSEDREDCILYSSWVAEKHTDW 648

  Fly   564 ----------------DLVILTNANINIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTKNSGPV 612
                            ||...||..|.:.:.   |:.:...:...|..  ...|.:|.   ||.:
Mouse   649 VPHGREKDVYRYVEDMDLKAFTNLKIKLPKI---CFDSAPMSGPRGKF--DLAFSSEV---SGTL 705

  Fly   613 PIVGSTRAQASLPP-------------VRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVI 664
            ....|.|.|...||             :||.|||||::..:| |.:.|...::.|||||:|.|..
Mouse   706 QKGSSKRPQPEEPPREDPPPKDPLAETIRKYFPETWVWDIVT-VNSTGVAEVEMTVPDTITEWKA 769

  Fly   665 TGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNS 729
            ....||..:||.:: :...::.|||||:..:|||||.|||...:...|.|||...::..|.::.|
Mouse   770 GALCLSNDTGLGLS-SVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMRMSVQLEAS 833

  Fly   730 DGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAG---- 790
            . .:..:...:.:.|..|....|..:.|           ::.||.:|.....::..::.:.
Mouse   834 P-DFTAVPVGDDHDSYCLSANGRHTSSW-----------LVTPKSLGNVNFSVSVEAQQSSEPCG 886

  Fly   791 ------------DRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEKAD-----N 838
                        |.:.::|.||.:|::           |.....||.......|.||..     .
Mouse   887 SEVATVPETGRKDTVVKVLIVEPEGIK-----------QEHTFNSLFCASDAEISEKMSLVLPPT 940

  Fly   839 VIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENK 903
            |::.|....|.|.|...:..:::..:|:|:|.|||||||..|.|:|..|.||....:..|:|:.|
Mouse   941 VVKDSARAHFSVMGDILSSAIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTK 1005

  Fly   904 AKRYVETGYQIELNYKRNDGSFSAWGQH--DALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLD 966
            |..::..|||.|||||..|||:||:|..  :..|:|||||:|::||.||..:|.||::.:.....
Mouse  1006 ALGFLRAGYQRELNYKHKDGSYSAFGDQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFT 1070

  Fly   967 FLVSRQSTDGKFKELGMVIHN----SHGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFV--- 1024
            :|..:|..:|.|:..|.:.||    .....:.|::::.:...|:.  :|....|:.:|:..:
Mouse  1071 WLSQQQKDNGCFRSSGSLFHNDIKGGVDDEMTLSAYITMALLESS--LPARHPVVSKALSCLESS 1133

  Fly  1025 ---VTEVHQSNEPYDLAIAALALSLARN---RNAYKVLDKLDKLATRRGDHKWWTGSDKCKSS-- 1081
               :.:...:|..|..|:.|.|.:||.|   ||  ::|..||:.|.:..:...|....|.:.|
Mouse  1134 WKTIEQGRNANFVYTKALMAYAFALAGNQDKRN--EILKSLDEEAIKEDNSIHWERPQKPRKSEH 1196

  Fly  1082 ----------EVETTSYVLLALLEHNISDEPKPI------VDWLISKRNSNGGFVSSQDTVVGIM 1130
                      |||..:||:||.|....:..|:.:      :.||..::||||||.|:|||||.:.
Mouse  1197 NLYKPQASSVEVEMNAYVVLARLTAQPAPSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALD 1261

  Fly  1131 ALTKY---ELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRA 1192
            ||:||   .......|..:.|:  ......:..:|...|...:|...||:...:..:...|:|..
Mouse  1262 ALSKYGAVTFSRRQKTSLVTIQ--STGSFSQKFQVENSNCLLLQQVPLPDIPGDYTISVSGEGCV 1324

  Fly  1193 QVQLTYRYNVATKEARPSF-------KLTTTVKKSHKG-RLILGICGTYTPIAASERNKTTNMAL 1249
            ..|.|.|||:..::.:.:|       .||....|.|.. ::.|.|  :||     .....:||.:
Mouse  1325 YAQTTLRYNMHLEKQQSAFALRVQTVPLTCNNPKGHNSFQISLEI--SYT-----GSRPASNMVI 1382

  Fly  1250 MQVQLPSGYVCDIEP-FADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTH--AV 1311
            ..|::.||:: .::| ...:|.:..:.|.|..|.:  |.:|.::::   .:.|....|...  :|
Mouse  1383 ADVKMLSGFI-PLKPTVKKLERLEHISRTEVSNNN--VLLYLDQVT---NQTLAFSFIIQQDISV 1441

  Fly  1312 ANLKPSWVRLYDYYATERSATEFY 1335
            .||:|:.|::||||.|:..|...|
Mouse  1442 RNLQPAIVKVYDYYETDEVAYAEY 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	28/84 (33%)
		A2M_N_2	411..542	CDD:285005	31/147 (21%)
		A2M	634..726	CDD:278630	34/91 (37%)
		A2M_2	859..1135	CDD:239227	102/308 (33%)
		A2M_comp	910..1135	CDD:284982	82/257 (32%)
		A2M_recep	1245..1335	CDD:284981	25/92 (27%)
Mug2	XP_006505762.1	A2M_N	129..221	CDD:376626	29/92 (32%)
		MG3	223..299	CDD:375334	19/78 (24%)
		MG4	340..434	CDD:375332	16/100 (16%)
		A2M_N_2	459..599	CDD:377903	32/139 (23%)
		A2M	740..830	CDD:365945	34/91 (37%)
		A2M_2	960..1266	CDD:239227	102/309 (33%)
		A2M_recep	1378..1465	CDD:369460	25/92 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840031
Domainoid	1	1.000	75	1.000	Domainoid score	I9015
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650