DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and Mug1

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_006505761.1	Gene:	Mug1 / 17836	MGIID:	99837	Length:	1483	Species:	Mus musculus

Alignment Length:	1551	Identity:	383/1551 - (24%)
Similarity:	667/1551 - (43%)	Gaps:	303/1551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LW------LILSSTI---LHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLT 57
            :|      |.|.|.:   ||...|.|.:..|.||.|..|.:.:...:.:.::....|..|:.||.
Mouse     1 MWKSRRAQLCLFSVLLAFLHSASLLNGDSKYMVLVPSQLYTETPEKICLHLYQLNETVTVTASLV 65

  Fly    58 GPSLNSRKYVDVQSMSSKS----VRFDIPKLTEGDYE----LKVMGSGGIEFQNSTKLSFAPDLN 114
              |.:.||.:..:.:..|.    |.|.||:|:..|.|    :.:.|... ||.....:......:
Mouse    66 --SQSGRKNLFDELVLDKDLFQCVSFIIPRLSSSDEEDFLYVDIKGPTH-EFSKRKAVLVKNKES 127

  Fly   115 WLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGE 179
            .:::|:||..||||..::|||:.:||..||.....|:.. |.|..:|.|..|:|||...|:....
Mouse   128 VVFVQTDKPVYKPGQSVKFRVVSMDKMLRPLNELLPLAY-IEDPKKNRIMQWRDIKTENGLKQMS 191

  Fly   180 LQLSDRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTF 244
            ..|:..|:.|.:.:....:...|..:...|.::|:|:|.|.:.....::.:...:..|...:||:
Mouse   192 FSLAAEPIQGPYKIVVHKESGEKEEHSFTVMEFVLPRFNVDLKVPNAMSVNDEVLSVTACGKYTY 256

  Fly   245 KKPVKGHVVATI----EGSSTEQSLPIDG------EVNVEFPISATAKR------LLKITAIVTE 293
            .|||.|||...:    |....|.:..:|.      |||:   ....:|:      |..:.|.|||
Mouse   257 GKPVPGHVKINVCRETETGCREVNSQLDNNGCSTQEVNI---TELQSKKRNYEVQLFHVNATVTE 318

  Fly   294 ELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCC 358
            |.|.::.:.:....:.:..:||..|...:|:|.|:....|..:.::.|.|:.:....:.     .
Mouse   319 EGTGLEFSRSGTTKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEKVFIK-----A 378

  Fly   359 QVSKNFSASLQNSIATEHIMLPETC---------------QSC----LVTSTFDTAENIERYIYK 404
            |.....||:..:........:..||               .||    .:.....:|:::...:|.
Mouse   379 QELSYTSATTTDQHGLAEFSIDTTCISGSSLHIKVNHKEEDSCSYFYCMEERHASAKHVAYAVYS 443

  Fly   405 LNKPLMIAINTKKP-----------QLRKLLK--INIISDTYLPYFIL---TVVARGNIVLSLFQ 453
            |:|. .|.::|:..           |...:||  :.::.:....|.::   :::..||....:..
Mouse   444 LSKS-YIYLDTETSSILPCNQIHTVQAHFILKGDLGVLKELIFYYLVMAQGSIIQTGNHTHQVEP 507

  Fly   454 EMKEKKKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPR 516
            .....|....:|....|::||.|.:.::.|: ||.:::|....:||:...|.::: .:|:::||.
Mouse   508 GEAPVKGKFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLRFSTSQSLPA 572

  Fly   517 DEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILN-------------NLATYSTDLVIL 568
            .:..|:|..:|.|..||..||||||||:..::|:...|.|             .|:....|.::.
Mouse   573 SQTRLQVTASPQSLCGLRAVDQSVLLLKPESELSPSWIYNLPGMQQNKFVPSSRLSEDQEDCILY 637

  Fly   569 T------NANI-------NIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTK------NSGPVPI 614
            :      :.|:       ::||     |...         :|.|.|.|...|      :.|.|||
Mouse   638 SSWLAEKHTNLVPHGTEKDVYR-----YVED---------MGLTAFTNLMIKLPIICFDYGMVPI 688

  Fly   615 VGSTRAQASL--------------------PP-------------VRKLFPETWLFSNITDVGAN 646
             .:.|.:..|                    ||             :||.|||||::..:| |.:.
Mouse   689 -SAPRVEFDLAFTPEISWSLRTTLSKRPEEPPRKDPSSNDPLTETIRKYFPETWVWDIVT-VNST 751

  Fly   647 GEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVI 711
            |...::.|||||:|.|......||..:||.:: :...::.|:|||:..:|||||.|||...:...
Mouse   752 GLAEVEMTVPDTITEWKAGALCLSNDTGLGLS-SVVPLQAFKPFFVEVSLPYSVVRGEAFMLKAT 815

  Fly   712 VFNYLGMDVKAKVLMDNS---------DGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGIS 767
            |.|||...::..|.::.|         |.|..:.                     :.||.....|
Mouse   816 VMNYLPTSMQMSVQLEASPDFTAVPVGDDQDSYC---------------------LSANGRHTSS 859

  Fly   768 FMIRPKKVGLTTLKITAISKYAG----------------DRLHQILKVEADGVQKYVNKAVLI-- 814
            :::.||.:|.....::|.::.:.                |.:.::|.||.:|:::....:.|.
Mouse   860 WLVTPKSLGNVNFSVSAEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPEGIKQEHTFSSLFCA 924

  Fly   815 -NVQRLNRRSLA-PPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNM 877
             :.:...:.||. ||          .|::.|....|.|.|...:..:.:..:|:|:|.|||||||
Mouse   925 SDAEISEKMSLVLPP----------TVVKDSARAHFSVMGDILSSAIRNTQNLLHMPYGCGEQNM 979

  Fly   878 FNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQH--DALGSTWLT 940
            ..|.|:|..|.||....:..|:|:.||..::..|||.|||||..|||:||:|..  :..|:||||
Mouse   980 VLFAPNIYVLKYLNETQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNGEREGNTWLT 1044

  Fly   941 AYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLL 1001
            |:|::||.||..:|.||::.:.....:|..:|..:|.|:..|.:.:|:.    ...:.|::::.:
Mouse  1045 AFVLKSFAQARAFIFIDESHITHAFTWLSQKQKDNGCFRSSGSLFNNAMKGGVDDEMTLSAYITM 1109

  Fly  1002 TFFENEEYMPKYKHVIDRAVEFV------VTEVHQSNEPYDLAIAALALSLARNRNAY-KVLDKL 1059
            ...|:.  :|....|:.:|:..:      :.:...::..|..|:.|.|.:||.|:|.. ::|..|
Mouse  1110 ALLESS--LPATHPVVSKALSCLESSWKTIEQERNASFVYTKALMAYAFALAGNQNKRDEILKSL 1172

  Fly  1060 DKLATRRGDHKWWTGSDKCK------------SSEVETTSYVLLALLEHNISDEPKPI------V 1106
            |:.|.:..:...|....|.:            |:|||..:||:||.|....:..|:.:      :
Mouse  1173 DEEAIKENNSIHWKRPQKSRKSEHHLYKPQASSAEVEMNAYVVLARLTAQPAPSPEDLTLSMSTI 1237

  Fly  1107 DWLISKRNSNGGFVSSQDTVVGIMALTKY-----------ELQSHASTEAIDIEFWHLNEDKKHV 1160
            .||..::||||||.|:|||||.:.||:||           .|.:..||.:...:|
Mouse  1238 MWLTKQQNSNGGFSSTQDTVVALDALSKYGAVTFSRSQKTTLVTIQSTGSFSQKF---------- 1292

  Fly  1161 RVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSF-------KLTTTVK 1218
            :|...|...:|...||:...:..:...|:|....|...|||:..::...:|       .||....
Mouse  1293 QVENSNRLLLQQVALPDIPGDYTISVSGEGCVYAQTMLRYNMHLEKQLSAFAIWVQTVPLTCNNP 1357

  Fly  1219 KSHKG-RLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEP-FADIEAISDVKRVETKN 1281
            |.|.. ::.|.|  :||     .....:||.:..|::.||:: .::| ...:|.:..|.|.|..|
Mouse  1358 KGHNSFQISLEI--SYT-----GSRPASNMVIADVKMLSGFI-PLKPTVKKLERLEHVSRTEVSN 1414

  Fly  1282 EDTEVHIYFEKLSPGDRKCLTLEAIYTH--AVANLKPSWVRLYDYYATERSATEFY 1335
            .:  |.||.::::   .:.|....|...  .|.||:|:.|::||||.|:..|...|
Mouse  1415 NN--VLIYLDQVT---NQTLAFSFIIQQDIPVRNLQPAIVKVYDYYETDEMAFAEY 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	27/84 (32%)
		A2M_N_2	411..542	CDD:285005	35/148 (24%)
		A2M	634..726	CDD:278630	33/91 (36%)
		A2M_2	859..1135	CDD:239227	99/306 (32%)
		A2M_comp	910..1135	CDD:284982	79/255 (31%)
		A2M_recep	1245..1335	CDD:284981	27/92 (29%)
Mug1	XP_006505761.1	A2M_N	129..221	CDD:376626	28/92 (30%)
		MG3	223..299	CDD:375334	19/78 (24%)
		MG4	340..439	CDD:375332	16/103 (16%)
		A2M_N_2	449..599	CDD:377903	36/149 (24%)
		A2M	740..830	CDD:365945	33/91 (36%)
		A2M_2	960..1266	CDD:239227	99/307 (32%)
		A2M_recep	1378..1465	CDD:369460	27/92 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840035
Domainoid	1	1.000	227	1.000	Domainoid score	I2492
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650