Protein Alignment Tep1 and tep-1

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001367060.1
• Gene: tep-1 / 173367
• WormBaseID: WBGene00013969
• Length: 1516
• Species: Caenorhabditis elegans
• Alignment Length: 1493
• Identity: 438/1493 - (29%)
• Similarity: 710/1493 - (47%)
• Gaps: 219/1493 - (14%)

  Fly    23 YSVLAPKTLRSNSAYNV-------------VVAIHNTTRTTEV----SVSLTGPSLNSRKYVDVQ 70
            |.::||..:|.:..::|             :|.|...|...|.    .:|...|.:  .:.|.:.
 Worm    40 YMLVAPAVVRPDQPFSVCMNLLKQATDEDMIVRIEVRTERNETIAARVISNLKPGI--AQTVSLS 102

  Fly    71 SMSSKSVRFDIPKLTEGDYELKVMG---SGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQ 132
            .|.::|:   .|:.:   |:|.:.|   :..:.|:|..:|.:......::||:|:|.|:|...::
 Worm   103 EMPAQSL---TPRQS---YKLYIRGETLNAELIFENENELKYDQKALSVFIQTDRAIYRPASLVR 161

  Fly   133 FRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTAT- 196
            :|.:.:..:.:|.|.:..||  |.|..:|||.....:...:|||||||||::..:||:|.:...
 Worm   162 YRAIVVKSDLKPYVGNATIK--IFDPSRNLISQTIGVTLDRGVYSGELQLAEETLLGDWFIEVET 224

  Fly   197 ---VQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATIE- 257
               |||:...|    ||.||:|||||.:.|:..:..:.. :...:.|:||:.|.|.|....::|
 Worm   225 SNGVQDKSSFT----VDTYVLPKFEVNIKTSSFITINDD-LSVFVDAKYTYGKGVAGKAKVSLEL 284

  Fly   258 ----------------GSSTEQSLPID--------GEVNVEFPISATAKRLL---------KITA 289
                            |...|:.|.::        ||..|.|......:..|         :|.|
 Worm   285 PWHRWHAMVPTIIDENGVKKEEELMVERTVKLNRQGEAAVVFSNDELKRHKLLHEWGGGSIRIVA 349

  Fly   290 IVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDS-SKMVNF 353
            .|||::|:|:.|.|..::..:...||:.......::||::......::.:|.:||..: .|.|..
 Worm   350 SVTEDITEIERNATHQISTFREEVKLDVEKQGDTFKPGLTYNVVVALKQMDDTPVKATLPKRVQV 414

  Fly   354 NVLCCQVSKNFSASLQNSIATEHIML------------PETCQSCLVTSTFD-------TAENI- 398
            :........:.::|||....|:.:.:            |..|.|..:.:.:|       ||..|
 Worm   415 STFYNYPYNHDTSSLQEEKETKIVEVDAHGTSVLTLQPPINCTSARIEAHYDIGGKDNFTATPIY 479

  Fly   399 -ERYIYKLNKPL-----MIAINTKKPQLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKE 457
             ..|:.....|.     ::|.|.....:.|.|..::.:...|......|::|.|||:|  |:|..
 Worm   480 SSLYVEAAVSPTKSFLQLLADNEGAVDVGKSLSFSLKATQPLSTITYQVMSRSNIVVS--QQMTV 542

  Fly   458 KKKSQEIEFEPTFALVPQATIFVHYIIDGVLMSDEKTVD-----IERDFENTIEILTTNEAL-PR 516
            ..:...|.|..|..:.|::.:.|:.||:.   |.|..||     :|..|:|.:.:....:|: |.
 Worm   543 NSEHATISFPATANMAPKSRLIVYAIIES---SQEVLVDALDFKVEGIFQNQVALSIDKQAVEPG 604

  Fly   517 DEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTDLV-----------ILTN 570
            ..|..||.::.:||||||.||||||||::|||:.|:.:..:|..|.::.|           .:..
 Worm   605 QNVKFKVTSDKNSFVGLLVVDQSVLLLKTGNDITREKVEQDLENYDSNNVGGGFGGPRPWEAIDR 669

  Fly   571 ANINIYR---SSGG-----CYTNPGYTNCTGSLI----------GRTMFKNE------------- 604
            ...:|:|   ..||     .::|.|....|.:|:          |..|.:|:
 Worm   670 KKRSIWRPWWGIGGSDAQSIFSNAGLVVLTDALLYREPQREFMSGTFMRRNKVMMMDGAPGMAEA 734

  Fly   605 -----PTKNSGPVPIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVI 664
                 |...|.|.|           |.|||.||.||::|::.  ..:||..::...|||:||||.
 Worm   735 AFAAPPMGGSSPPP-----------PTVRKFFPHTWIWSDLN--STSGEVEMEIEAPDTITSWVA 786

  Fly   665 TGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYL--GMDVKAKVLMD 727
            :.|:::.::||.|....|::|||:||||..||||:|:|||..|:.|:||||:  ..||...:..|
 Worm   787 STFAINEENGLGVAPTTSKLRVFRPFFIQLNLPYAVRRGEKFALLVLVFNYMEKEQDVTVTLKYD 851

  Fly   728 NSDGQYEFIETTNKNVSQYLRGVRRKKTLWIP-ANTGRGISFMIRPKKVGLTTLKITAISKYAGD 791
            ...| |:.::.....|.:...|.:..:.:.:. ..|.:.:.|.|.|..:|...:.|:||:...||
 Worm   852 KDSG-YDLLKKDGTVVRRDEVGQQNVRIVSVAGGGTSKAVYFPIVPSSIGEIPVHISAIASQGGD 915

  Fly   792 RLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEKADNVIEGSETVEFEVCGTSQA 856
            .:...|:|:..|.:...|...:|:   ||..| :...|.:.:...::|::||:....:|.|....
 Worm   916 AVEMNLRVDPQGYKVDRNIPFVID---LNNNS-SDFSKNLELIWPNDVVDGSQKARLDVIGDMMG 976

  Fly   857 PQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRN 921
            |.|.:...||.:|.|||||||.|.||:||.:.||:|.||.:.::|.||.:::|.|.|.||.|||.
 Worm   977 PVLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRA 1041

  Fly   922 DGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIH 986
            |.||||:|..|..|||||||:|:||||.|.:|..:|.||:...:.||.|:|...|.|.|.|.|.|
 Worm  1042 DNSFSAFGDSDKAGSTWLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHH 1106

  Fly   987 -----NSHGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSL 1046
                 .:....:|||:|||::..||.....|....:::.::.|      |...|.:|:.|.||.|
 Worm  1107 KDMQGGAQDGGVALTAFVLISILENGMENGKAVTYLEKHLDEV------SGNAYTMAVVAYALQL 1165

  Fly  1047 ARNRNAYKVLDKL--DKLATRRGDHKWWTGS---DKCKSS----------EVETTSYVLLALLEH 1096
            |:::.|.|..:.|  .|:..:.||.|:.:..   :|.|.|          ::|||||.:|:.|..
 Worm  1166 AKSKQAGKAFENLKKHKIVEKSGDVKFASAQKKVEKLKESRAYMFQARPVDIETTSYAVLSYLAQ 1230

  Fly  1097 NISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKH-V 1160
            |.:.|...|:.||:|:||..|||.|:||||:.:.||:.|...:::......:..  ||....| .
 Worm  1231 NQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSYAAVTYSDKHTSQVTI--LNGKHTHSF 1293

  Fly  1161 RVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKG-R 1224
            .:...|...:|::||....:.|.:.|.|.|....||:|.|...:......|..:..:|:...| |
 Worm  1294 DINIRNAIVLQSYQLSSLNDAVSINANGTGVVFAQLSYSYYRDSLNDDAPFFCSQEIKEIRAGNR 1358

  Fly  1225 LILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKNEDTEVHIY 1289
            |.|.:|..||      |...:||||.::...|||..|.|....:.:|.|::|||.:.:||::::|
 Worm  1359 LQLDLCCNYT------RPGKSNMALAEIDALSGYRFDAEQVHTLTSIEDLQRVEMEKDDTKMNVY 1417

  Fly  1290 FEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHV--DTSLCDICHGNEC 1350
            |..|. |...||:|.:..|:.||:.||:..||.|||..|......|..  ..||.:.| |.:|
 Worm  1418 FNPLG-GRPVCLSLYSDVTYQVADQKPANFRLVDYYDPEEQLKMTYAAKQTRSLQEKC-GEDC 1478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	366/1224 (30%)
		A2M_2	859..1135	CDD:239227	119/295 (40%)
		A2M_recep	1243..1336	CDD:462226	34/92 (37%)
tep-1	NP_001367060.1	YfaS	<139..1342	CDD:441940	367/1240 (30%)
		A2M_2	978..1269	CDD:239227	119/296 (40%)
		A2M_recep	1371..1462	CDD:462226	34/91 (37%)