DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and Hc

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_017171158.1	Gene:	Hc / 15139	MGIID:	96031	Length:	1684	Species:	Mus musculus

Alignment Length:	1607	Identity:	388/1607 - (24%)
Similarity:	645/1607 - (40%)	Gaps:	351/1607 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVD 68
            |:.::|:|          :|.:.|||.||..|:.|||:.:|..|...:.::||       :.|.|
Mouse    18 LVEAATLL----------IYVISAPKILRVGSSENVVIQVHGYTEAFDATLSL-------KSYPD 65

  Fly    69 VQSMSSKSVRFD---IPKLTEGDYE-----------------------LKVMGSGGIEFQNSTKL 107
                  |.|.|.   :....|..::                       |:|:..   .|..|.|:
Mouse    66 ------KKVTFSSGYVNLSPENKFQNAALLTLQPNQVPREESPVSHVYLEVVSK---HFSKSKKI 121

  Fly   108 SFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPA 172
            ....:...|:|.:||..|.|...::.||..|..:.:||..:..:.....:|.:..|....|
Mouse   122 PITYNNGILFIHTDKPVYTPDQSVKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEEND---- 182

  Fly   173 KGVYSG-----ELQLSDRPVLGNWTVTATVQDEGKVTNV--LVVDKYVVPKFEVVVLTAKNVAAS 230
               |:|     :.::...|..|.||:.|..:.:...|..  ..:.:||:|:|.|.:...:..
Mouse   183 ---YTGIISFPDFKIPSNPKYGVWTIKANYKKDFTTTGTAYFEIKEYVLPRFSVSIELERTF--- 241

  Fly   231 AGY-----IRATIKARYTFKKPVKGHVVATIEG--------------SSTEQSLPIDGEVNVEFP 276
            .||     ...|:||||.:.|.|....|....|              .:|:.:..:||...:.|.
Mouse   242 IGYKNFKNFEITVKARYFYNKVVPDAEVYAFFGLREDIKDEEKQMMHKATQAAKLVDGVAQISFD 306

  Fly   277 ISATAKRL------------LKITAIVTE---------ELTDIKHNGTAYVTVHQHRHKLEDLFW 320
            .....|.|            |.|...|||         |:..:|:..:.|.        |..:..
Mouse   307 SETAVKELSYNSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYT--------LNLVAT 363

  Fly   321 PTHYRPGVSSEFKTVVRN-----LDGSPVMDSSKMVNFN--------------------VLCCQV 360
            |...:||:....|..|::     :.|.||...::.|:.|                    |....:
Mouse   364 PLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMAQTVDVNQETSDLETKRSITHDTDGVAVFVLNL 428

  Fly   361 SKNFSASLQNSIATEHIMLPETCQSCLVTSTFDTAENIERYIY----KLNKPLM------IAINT 415
            ..|.:. |:..|.|:...|||..|:.........:...:.|||    :..||::      |.:..
Mouse   429 PSNVTV-LKFEIRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIMVTP 492

  Fly   416 KKPQLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFV 480
            |.|.:.|:        |:..|.||   ::|.||....:|.......|.|....|..:||.|.:.|
Mouse   493 KSPYIDKI--------THYNYLIL---SKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLV 546

  Fly   481 HYIIDG----VLMSDEKTVDIERDFENTIEI-LTTNEAL--PRDEVSLKVKTNPHSFVGLLGVDQ 538
            :||:.|    .|::|...::||....|.::: |:.:|.:  |...|||.:.|...|:|.|..||:
Mouse   547 YYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDR 611

  Fly   539 SVLLLR-------------------------SGNDLNRDLILNNLATYSTDLVILTNANIN---- 574
            :|..::                         .|:| |.|:.      :...|..|||||.:
Mouse   612 AVYKVQGNAKRAMQRVFQALDEKSDLGCGAGGGHD-NADVF------HLAGLTFLTNANADDSHY 669

  Fly   575 -------IYRSSGG-----------------------CYTNPG---YTNC--------TGSLIGR 598
                   |.||...                       ||....   |..|        .|.|..|
Mouse   670 RDDSCKEILRSKRNLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIR 734

  Fly   599 TM-----FKNEPTKNSGPVPI-VGSTRAQASLP----PVRKLFPETWLFSNITDVGANGEYIIKE 653
            ..     ..|:..|.|...|: :|....:..||    .:|..|||:||: .|..|....:  ::.
Mouse   735 AFNECCTIANKIRKESPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLW-EIHRVPKRKQ--LQV 796

  Fly   654 TVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGM 718
            |:||:||:|.|.|..:| .:|:.|. :..:.:||:..|:..|:||||.|||.|.:...|:||:..
Mouse   797 TLPDSLTTWEIQGIGIS-DNGICVA-DTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYMTS 859

  Fly   719 DVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLW--IPANTGRGISFMIRPKKVGLTTLK 781
            ..|..|.|...:|    |.|:..:.:. |...|..:.::  |..::...::|.:.|.::||.::.
Mouse   860 GTKFCVKMSAVEG----ICTSGSSAAS-LHTSRPSRCVFQRIEGSSSHLVTFTLLPLEIGLHSIN 919

  Fly   782 ITAISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRL----NRRSLAP---PEKTIIIEKADNV 839
            .:..:.:..|.|.:.|:|..:||::.....|:::.:.:    |||...|   |...:...|.:.:
Mouse   920 FSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLVPKTKVERI 984

  Fly   840 --IEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNR------- 895
              ::|....||    .|.....|.::.|.|||.|..|..:.:..|......||:|.|.
Mouse   985 LSVKGLLVGEF----LSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNHWNIFYPD 1045

  Fly   896 ---QDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDID 957
               :.|.:|.|.|:    |....::|:..|.|:|.|  ..|..||||||:.:|...|.|||:..|
Mouse  1046 TLSKRQSLEKKIKQ----GVVSVMSYRNADYSYSMW--KGASASTWLTAFALRVLGQVAKYVKQD 1104

  Fly   958 KNVLVAGLDFLVSR-QSTDGKFKE---------LGMVIHNSHGSPLALTSFVLLTFFENEEYMPK 1012
            :|.:...|.:||.: |..:|.|||         .|.:...:....|.||:|.::...:..:..|.
Mouse  1105 ENSICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDICPT 1169

  Fly  1013 YK-H-VIDRAVEFVVTEVHQSNEPYDLAIAALALSLA-RNRNAYK-VLDKLDKLATRRGD---HK 1070
            .| | .:|:|..|::.....|...:.|||.|.||||. |....:: ::..|.|.|..:||   ::
Mouse  1170 MKIHTALDKADSFLLENTLPSKSTFTLAIVAYALSLGDRTHPRFRLIVSALRKEAFVKGDPPIYR 1234

  Fly  1071 WWTGSDKCKSSE---------VETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTV 1126
            :|..:.|...|.         ||||:|.|||.|:....:...||:.||..::...|||.|:|||:
Mouse  1235 YWRDTLKRPDSSVPSSGTAGMVETTAYALLASLKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTI 1299

  Fly  1127 VGIMALTKYEL---QSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKG 1188
            ..|..||:|.|   |.|...: |::.:.|..:..|: :|| |..|..:..::..|.:.|......
Mouse  1300 NAIEGLTEYSLLLKQIHLDMD-INVAYKHEGDFHKY-KVT-EKHFLGRPVEVSLNDDLVVSTGYS 1361

  Fly  1189 QGRAQVQL-TYRYNVATKEARPSFKL---TTTVKKSHKGRL-------ILGICGTYTPIAASERN 1242
            .|.|.|.: |..:.::..|...||.|   |..::.|...||       |:. |.:|.| :..|..
Mouse  1362 SGLATVYVKTVVHKISVSEEFCSFYLKIDTQDIEASSHFRLSDSGFKRIIA-CASYKP-SKEEST 1424

  Fly  1243 KTTNMALMQVQLPSGYVCDIEPFADIEA-ISDVKRVETKNEDTEVHIYFE--KLSPGDRKCLTLE 1304
            ..::.|:|.:.||:|...:.|   |:.| :..|.::.|..:..:.|:..:  .:...|..|:...
Mouse  1425 SGSSHAVMDISLPTGIGANEE---DLRALVEGVDQLLTDYQIKDGHVILQLNSIPSRDFLCVRFR 1486

  Fly  1305 AIYTHAVANLKPSWVRLYDYYATERSATEFYHV-DTSLCDICHGNEC 1350
            ......|..|.|:...:|:|:..::..|..|.: ||.|..:|.|..|
Mouse  1487 IFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAAC 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	21/89 (24%)
		A2M_N_2	411..542	CDD:285005	40/137 (29%)
		A2M	634..726	CDD:278630	32/91 (35%)
		A2M_2	859..1135	CDD:239227	96/311 (31%)
		A2M_comp	910..1135	CDD:284982	80/250 (32%)
		A2M_recep	1245..1335	CDD:284981	19/92 (21%)
Hc	XP_017171158.1	MG1	27..124	CDD:375333	25/112 (22%)
		A2M_N	130..223	CDD:376626	22/99 (22%)
		MG3	225..309	CDD:375334	20/86 (23%)
		MG4	358..461	CDD:375332	20/103 (19%)
		A2M_N_2	474..614	CDD:377903	41/150 (27%)
		ANATO	690..758	CDD:237984	11/67 (16%)
		A2M	780..867	CDD:365945	32/91 (35%)
		complement_C3_C4_C5	1003..1308	CDD:239226	96/310 (31%)
		A2M_recep	1427..1517	CDD:369460	19/92 (21%)
		NTR_like	1535..1683	CDD:382999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840003
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.800