Protein Alignment Tep1 and Hc

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_017171158.1
• Gene: Hc / 15139
• MGIID: 96031
• Length: 1684
• Species: Mus musculus
• Alignment Length: 1607
• Identity: 388/1607 - (24%)
• Similarity: 645/1607 - (40%)
• Gaps: 351/1607 - (21%)

  Fly     4 LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVD 68
            |:.::|:|          :|.:.|||.||..|:.|||:.:|..|...:.::||       :.|.|
Mouse    18 LVEAATLL----------IYVISAPKILRVGSSENVVIQVHGYTEAFDATLSL-------KSYPD 65

  Fly    69 VQSMSSKSVRFD---IPKLTEGDYE-----------------------LKVMGSGGIEFQNSTKL 107
                  |.|.|.   :....|..::                       |:|:..   .|..|.|:
Mouse    66 ------KKVTFSSGYVNLSPENKFQNAALLTLQPNQVPREESPVSHVYLEVVSK---HFSKSKKI 121

  Fly   108 SFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPA 172
            ....:...|:|.:||..|.|...::.||..|..:.:||..:..:.....:|.:..|....|
Mouse   122 PITYNNGILFIHTDKPVYTPDQSVKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEEND---- 182

  Fly   173 KGVYSG-----ELQLSDRPVLGNWTVTATVQDEGKVTNV--LVVDKYVVPKFEVVVLTAKNVAAS 230
               |:|     :.::...|..|.||:.|..:.:...|..  ..:.:||:|:|.|.:...:..
Mouse   183 ---YTGIISFPDFKIPSNPKYGVWTIKANYKKDFTTTGTAYFEIKEYVLPRFSVSIELERTF--- 241

  Fly   231 AGY-----IRATIKARYTFKKPVKGHVVATIEG--------------SSTEQSLPIDGEVNVEFP 276
            .||     ...|:||||.:.|.|....|....|              .:|:.:..:||...:.|.
Mouse   242 IGYKNFKNFEITVKARYFYNKVVPDAEVYAFFGLREDIKDEEKQMMHKATQAAKLVDGVAQISFD 306

  Fly   277 ISATAKRL------------LKITAIVTE---------ELTDIKHNGTAYVTVHQHRHKLEDLFW 320
            .....|.|            |.|...|||         |:..:|:..:.|.        |..:..
Mouse   307 SETAVKELSYNSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYT--------LNLVAT 363

  Fly   321 PTHYRPGVSSEFKTVVRN-----LDGSPVMDSSKMVNFN--------------------VLCCQV 360
            |...:||:....|..|::     :.|.||...::.|:.|                    |....:
Mouse   364 PLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMAQTVDVNQETSDLETKRSITHDTDGVAVFVLNL 428

  Fly   361 SKNFSASLQNSIATEHIMLPETCQSCLVTSTFDTAENIERYIY----KLNKPLM------IAINT 415
            ..|.:. |:..|.|:...|||..|:.........:...:.|||    :..||::      |.:..
Mouse   429 PSNVTV-LKFEIRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIMVTP 492

  Fly   416 KKPQLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFV 480
            |.|.:.|:        |:..|.||   ::|.||....:|.......|.|....|..:||.|.:.|
Mouse   493 KSPYIDKI--------THYNYLIL---SKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLV 546

  Fly   481 HYIIDG----VLMSDEKTVDIERDFENTIEI-LTTNEAL--PRDEVSLKVKTNPHSFVGLLGVDQ 538
            :||:.|    .|::|...::||....|.::: |:.:|.:  |...|||.:.|...|:|.|..||:
Mouse   547 YYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDR 611

  Fly   539 SVLLLR-------------------------SGNDLNRDLILNNLATYSTDLVILTNANIN---- 574
            :|..::                         .|:| |.|:.      :...|..|||||.:
Mouse   612 AVYKVQGNAKRAMQRVFQALDEKSDLGCGAGGGHD-NADVF------HLAGLTFLTNANADDSHY 669

  Fly   575 -------IYRSSGG-----------------------CYTNPG---YTNC--------TGSLIGR 598
                   |.||...                       ||....   |..|        .|.|..|
Mouse   670 RDDSCKEILRSKRNLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIR 734

  Fly   599 TM-----FKNEPTKNSGPVPI-VGSTRAQASLP----PVRKLFPETWLFSNITDVGANGEYIIKE 653
            ..     ..|:..|.|...|: :|....:..||    .:|..|||:||: .|..|....:  ::.
Mouse   735 AFNECCTIANKIRKESPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLW-EIHRVPKRKQ--LQV 796

  Fly   654 TVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGM 718
            |:||:||:|.|.|..:| .:|:.|. :..:.:||:..|:..|:||||.|||.|.:...|:||:..
Mouse   797 TLPDSLTTWEIQGIGIS-DNGICVA-DTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYMTS 859

  Fly   719 DVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLW--IPANTGRGISFMIRPKKVGLTTLK 781
            ..|..|.|...:|    |.|:..:.:. |...|..:.::  |..::...::|.:.|.::||.::.
Mouse   860 GTKFCVKMSAVEG----ICTSGSSAAS-LHTSRPSRCVFQRIEGSSSHLVTFTLLPLEIGLHSIN 919

  Fly   782 ITAISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRL----NRRSLAP---PEKTIIIEKADNV 839
            .:..:.:..|.|.:.|:|..:||::.....|:::.:.:    |||...|   |...:...|.:.:
Mouse   920 FSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLVPKTKVERI 984

  Fly   840 --IEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNR------- 895
              ::|....||    .|.....|.::.|.|||.|..|..:.:..|......||:|.|.
Mouse   985 LSVKGLLVGEF----LSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNHWNIFYPD 1045

  Fly   896 ---QDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDID 957
               :.|.:|.|.|:    |....::|:..|.|:|.|  ..|..||||||:.:|...|.|||:..|
Mouse  1046 TLSKRQSLEKKIKQ----GVVSVMSYRNADYSYSMW--KGASASTWLTAFALRVLGQVAKYVKQD 1104

  Fly   958 KNVLVAGLDFLVSR-QSTDGKFKE---------LGMVIHNSHGSPLALTSFVLLTFFENEEYMPK 1012
            :|.:...|.:||.: |..:|.|||         .|.:...:....|.||:|.::...:..:..|.
Mouse  1105 ENSICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDICPT 1169

  Fly  1013 YK-H-VIDRAVEFVVTEVHQSNEPYDLAIAALALSLA-RNRNAYK-VLDKLDKLATRRGD---HK 1070
            .| | .:|:|..|::.....|...:.|||.|.||||. |....:: ::..|.|.|..:||   ::
Mouse  1170 MKIHTALDKADSFLLENTLPSKSTFTLAIVAYALSLGDRTHPRFRLIVSALRKEAFVKGDPPIYR 1234

  Fly  1071 WWTGSDKCKSSE---------VETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTV 1126
            :|..:.|...|.         ||||:|.|||.|:....:...||:.||..::...|||.|:|||:
Mouse  1235 YWRDTLKRPDSSVPSSGTAGMVETTAYALLASLKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTI 1299

  Fly  1127 VGIMALTKYEL---QSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKG 1188
            ..|..||:|.|   |.|...: |::.:.|..:..|: :|| |..|..:..::..|.:.|......
Mouse  1300 NAIEGLTEYSLLLKQIHLDMD-INVAYKHEGDFHKY-KVT-EKHFLGRPVEVSLNDDLVVSTGYS 1361

  Fly  1189 QGRAQVQL-TYRYNVATKEARPSFKL---TTTVKKSHKGRL-------ILGICGTYTPIAASERN 1242
            .|.|.|.: |..:.::..|...||.|   |..::.|...||       |:. |.:|.| :..|..
Mouse  1362 SGLATVYVKTVVHKISVSEEFCSFYLKIDTQDIEASSHFRLSDSGFKRIIA-CASYKP-SKEEST 1424

  Fly  1243 KTTNMALMQVQLPSGYVCDIEPFADIEA-ISDVKRVETKNEDTEVHIYFE--KLSPGDRKCLTLE 1304
            ..::.|:|.:.||:|...:.|   |:.| :..|.::.|..:..:.|:..:  .:...|..|:...
Mouse  1425 SGSSHAVMDISLPTGIGANEE---DLRALVEGVDQLLTDYQIKDGHVILQLNSIPSRDFLCVRFR 1486

  Fly  1305 AIYTHAVANLKPSWVRLYDYYATERSATEFYHV-DTSLCDICHGNEC 1350
            ......|..|.|:...:|:|:..::..|..|.: ||.|..:|.|..|
Mouse  1487 IFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAAC 1533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	320/1302 (25%)
		A2M_2	859..1135	CDD:239227	96/311 (31%)
		A2M_recep	1243..1336	CDD:462226	19/95 (20%)
Hc	XP_017171158.1	MG1	25..124	CDD:465508	26/124 (21%)
		YfaS	<131..1308	CDD:441940	303/1233 (25%)
		A2M_BRD	474..614	CDD:462235	41/150 (27%)
		ANATO	690..758	CDD:237984	11/67 (16%)
		complement_C3_C4_C5	1003..1308	CDD:239226	96/310 (31%)
		A2M_recep	1427..1518	CDD:462226	19/93 (20%)
		NTR_like	1535..1683	CDD:470599