DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and A2ML1

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_011518868.1	Gene:	A2ML1 / 144568	HGNCID:	23336	Length:	1467	Species:	Homo sapiens

Alignment Length:	1532	Identity:	384/1532 - (25%)
Similarity:	625/1532 - (40%)	Gaps:	311/1532 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSR--KYVDVQSMSSKSVRFDIPKLT 85
            |.|..|..|...|...|.:.:.......:.:|:|.......:  :|..::......:.|.:|...
Human    23 YLVTLPARLNFPSVQKVCLDLSPGYSDVKFTVTLETKDKTQKLLEYSGLKKRHLHCISFLVPPPA 87

  Fly    86 EGDYE---LKVMGSG-GIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAV 146
            .|..|   ::|.|.| .|.|:...|:......|..::|:||..|.||.::.||::.:|.|..| |
Human    88 GGTEEVATIRVSGVGNNISFEEKKKVLIQRQGNGTFVQTDKPLYTPGQQVYFRIVTMDSNFVP-V 151

  Fly   147 IDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNVLVVDK 211
            .||...:|::|.:.|.|..|.::.|.:|:.....||:...:||.:||...   |||......|::
Human   152 NDKYSMVELQDPNSNRIAQWLEVVPEQGIVDLSFQLAPEAMLGTYTVAVA---EGKTFGTFSVEE 213

  Fly   212 YVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHV-VATIEGSST-------EQSLP-- 266
            ||:|||:|.|:..|.::.........|..|||:.||:.|.| |:..:.::|       .:.||
Human   214 YVLPKFKVEVVEPKELSTVQESFLVKICCRYTYGKPMLGAVQVSVCQKANTYWYREVEREQLPDK 278

  Fly   267 ---IDGEVNVEFPISATA------------KRLLKITAIVTEELTDIKHNGT--AYVTVHQHRHK 314
               :.|:.:.....||..            ...:.|.|.|.||.|.::.|.|  .|::.......
Human   279 CRNLSGQTDKTGCFSAPVDMATFDLIGYAYSHQINIVATVVEEGTGVEANATQNIYISPQMGSMT 343

  Fly   315 LEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIML 379
            .||.  ...|.|......|..||..|.|.:.        |.|...|....:.:...::.|::
Human   344 FEDT--SNFYHPNFPFSGKIRVRGHDDSFLK--------NHLVFLVIYGTNGTFNQTLVTDN--- 395

  Fly   380 PETCQSCLVTSTFDTA----------------------ENIERY--------------------I 402
                 :.|...|.:|:                      |.:.||                    |
Human   396 -----NGLAPFTLETSGWNGTDVSLEGKFQMEDLVYNPEQVPRYYQNAYLHLRPFYSTTRSFLGI 455

  Fly   403 YKLNKPLMIAINTKKPQLRKLLKINIISDTYLP----------YFILTVVARGNIVLSLFQEMKE 457
            ::||.||...    :||       .::.|.|:.          .|...::.:|::|:...:.:..
Human   456 HRLNGPLKCG----QPQ-------EVLVDYYIDPADASPDQEISFSYYLIGKGSLVMEGQKHLNS 509

  Fly   458 KKKSQEIEFEP----TFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEIL--------- 508
            |||..:..|..    |..|.|..::.::.|. .|.:::|:....:|..|:|..:::
Human   510 KKKGLKASFSLSLTFTSRLAPDPSLVIYAIFPSGGVVADKIQFSVEMCFDNQADLIPKLYLSLPQ 574

  Fly   509 -----TTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLR------------------------ 544
                 :.::.||..||.|:::..|.|...|..||:||||||
Human   575 VSLGFSPSQQLPGAEVELQLQAAPGSLCALRAVDESVLLLRPDRELSNRSVYGMFPFWYGHYPYQ 639

  Fly   545 ------------------------SGNDLNRDLILNNLATYSTDLV---------ILTNANINIY 576
                                    .|:...|.:|.....:..|||.         ||:||.|
Human   640 VAEYDQCPVSGPWDFPQPLIDPMPQGHSSQRSIIWRPSFSEGTDLFSFFRDVGLKILSNAKI--- 701

  Fly   577 RSSGGC-YTNPGYTNCTGSLIGRTMFKNEPTKNSGPVPIVGSTRAQASLPPVRKLFPETWLFSNI 640
            :....| :.:|.|:...|:..|..    |..::|.|:       .||....||:.||||||: ::
Human   702 KKPVDCSHRSPEYSTAMGAGGGHP----EAFESSTPL-------HQAEDSQVRQYFPETWLW-DL 754

  Fly   641 TDVGANGEYIIKETVPDTLTSWVI--------TGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLP 697
            ..:|.:|:..:..||||.:|.|..        .||.|||..||.         .|:|||:...||
Human   755 FPIGNSGKEAVHVTVPDAITEWKAMSFCTSQSRGFGLSPTVGLT---------AFKPFFVDLTLP 810

  Fly   698 YSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLW-IPAN 761
            |||.|||...:...:||||...::.:..:..|. :|:.....:...|..|.....|...| |.|.
Human   811 YSVVRGESFRLTATIFNYLKDCIRVQTDLAKSH-EYQLESWADSQTSSCLCADDAKTHHWNITAV 874

  Fly   762 TGRGISFMIRPK----------KVGLTTLKITAISKYAGDRLHQILKVEADGVQKYVNKAVLINV 816
            ....|:|.|..|          :.|...      .|...|.|.:.:.|:.:||.          |
Human   875 KLGHINFTISTKILDSNEPCGGQKGFVP------QKGRSDTLIKPVLVKPEGVL----------V 923

  Fly   817 QRLNRRSLAPPEK----TIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNM 877
            ::.:...|.|..|    ::.:|...:::..|......|.|......|::||.||.:|.|||||||
Human   924 EKTHSSLLCPKGKVASESVSLELPVDIVPDSTKAYVTVLGDIMGTALQNLDGLVQMPSGCGEQNM 988

  Fly   878 FNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAY 942
            ..|.|.|..|.||:......:||.::|..::|.|||.||.||.::||:||:|:.|..|:|||||:
Human   989 VLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNGNTWLTAF 1053

  Fly   943 VIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLLTF 1003
            |.:.|.||.|:|.||...:...|.::...|...|.:..:|.::|.:.    ...::||::|....
Human  1054 VTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAAL 1118

  Fly  1004 FENEEYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDK-LDKLATRRG 1067
            .|..:.:.  ..::.:.:..:......:...|..|:.|...|||...:...:|.| ||:.|...|
Human  1119 LEMGKDVD--DPMVSQGLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLDQQAIISG 1181

  Fly  1068 DHKWWTGSDKCKSS----------EVETTSYVLLA------LLEHNISDEPKPIVDWLISKRNSN 1116
            :..:|:......|:          :||.|:|.|||      |.:..|: :...||.||..:.|:.
Human  1182 ESIYWSQKPTPSSNASPWSEPAAVDVELTAYALLAQLTKPSLTQKEIA-KATSIVAWLAKQHNAY 1245

  Fly  1117 GGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNE 1181
            |||.|:|||||.:.||.||...::..:|.|::........::...:...|....|...||.....
Human  1246 GGFSSTQDTVVALQALAKYATTAYMPSEEINLVVKSTENFQRTFNIQSVNRLVFQQDTLPNVPGM 1310

  Fly  1182 VKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSH------KGRLILGICGTYTPIAASE 1240
            ..|.|.|||...||...|||:.......:|.|:..:.|:.      ...|.|.|..:|....:|
Human  1311 YTLEASGQGCVYVQTVLRYNILPPTNMKTFSLSVEIGKARCEQPTSPRSLTLTIHTSYVGSRSS- 1374

  Fly  1241 RNKTTNMALMQVQLPSGYVCDIEPFADIEAISD-------VKRVETKNEDTEVHIYFEKLSPGDR 1298
                :|||:::|::.||       |:.:|..:.       ||:||. ..|| ::||.::|.. :.
Human  1375 ----SNMAIVEVKMLSG-------FSPMEGTNQLLLQQPLVKKVEF-GTDT-LNIYLDELIK-NT 1425

  Fly  1299 KCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY 1335
            :..|.....:..|.||||:.:::||||..:..||..|
Human  1426 QTYTFTISQSVLVTNLKPATIKVYDYYLPDEQATIQY 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	27/84 (32%)
		A2M_N_2	411..542	CDD:285005	32/159 (20%)
		A2M	634..726	CDD:278630	34/99 (34%)
		A2M_2	859..1135	CDD:239227	98/296 (33%)
		A2M_comp	910..1135	CDD:284982	75/245 (31%)
		A2M_recep	1245..1335	CDD:284981	29/96 (30%)
A2ML1	XP_011518868.1	A2M_N	122..211	CDD:280081	30/92 (33%)
		YfaS	<123..>1055	CDD:225248	252/1005 (25%)
		A2M_N_2	455..613	CDD:285005	37/168 (22%)
		A2M	749..839	CDD:278630	34/99 (34%)
		A2M_2	969..1264	CDD:239227	98/297 (33%)
		A2M_comp	1021..1266	CDD:284982	77/247 (31%)
		A2M_recep	1375..1462	CDD:284981	29/96 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650