Protein Alignment Tep1 and A2ML1

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_011518868.1
• Gene: A2ML1 / 144568
• HGNCID: 23336
• Length: 1467
• Species: Homo sapiens
• Alignment Length: 1532
• Identity: 384/1532 - (25%)
• Similarity: 625/1532 - (40%)
• Gaps: 311/1532 - (20%)

  Fly    23 YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSR--KYVDVQSMSSKSVRFDIPKLT 85
            |.|..|..|...|...|.:.:.......:.:|:|.......:  :|..::......:.|.:|...
Human    23 YLVTLPARLNFPSVQKVCLDLSPGYSDVKFTVTLETKDKTQKLLEYSGLKKRHLHCISFLVPPPA 87

  Fly    86 EGDYE---LKVMGSG-GIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAV 146
            .|..|   ::|.|.| .|.|:...|:......|..::|:||..|.||.::.||::.:|.|..| |
Human    88 GGTEEVATIRVSGVGNNISFEEKKKVLIQRQGNGTFVQTDKPLYTPGQQVYFRIVTMDSNFVP-V 151

  Fly   147 IDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNVLVVDK 211
            .||...:|::|.:.|.|..|.::.|.:|:.....||:...:||.:||...   |||......|::
Human   152 NDKYSMVELQDPNSNRIAQWLEVVPEQGIVDLSFQLAPEAMLGTYTVAVA---EGKTFGTFSVEE 213

  Fly   212 YVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHV-VATIEGSST-------EQSLP-- 266
            ||:|||:|.|:..|.::.........|..|||:.||:.|.| |:..:.::|       .:.||
Human   214 YVLPKFKVEVVEPKELSTVQESFLVKICCRYTYGKPMLGAVQVSVCQKANTYWYREVEREQLPDK 278

  Fly   267 ---IDGEVNVEFPISATA------------KRLLKITAIVTEELTDIKHNGT--AYVTVHQHRHK 314
               :.|:.:.....||..            ...:.|.|.|.||.|.::.|.|  .|::.......
Human   279 CRNLSGQTDKTGCFSAPVDMATFDLIGYAYSHQINIVATVVEEGTGVEANATQNIYISPQMGSMT 343

  Fly   315 LEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIML 379
            .||.  ...|.|......|..||..|.|.:.        |.|...|....:.:...::.|::
Human   344 FEDT--SNFYHPNFPFSGKIRVRGHDDSFLK--------NHLVFLVIYGTNGTFNQTLVTDN--- 395

  Fly   380 PETCQSCLVTSTFDTA----------------------ENIERY--------------------I 402
                 :.|...|.:|:                      |.:.||                    |
Human   396 -----NGLAPFTLETSGWNGTDVSLEGKFQMEDLVYNPEQVPRYYQNAYLHLRPFYSTTRSFLGI 455

  Fly   403 YKLNKPLMIAINTKKPQLRKLLKINIISDTYLP----------YFILTVVARGNIVLSLFQEMKE 457
            ::||.||...    :||       .::.|.|:.          .|...::.:|::|:...:.:..
Human   456 HRLNGPLKCG----QPQ-------EVLVDYYIDPADASPDQEISFSYYLIGKGSLVMEGQKHLNS 509

  Fly   458 KKKSQEIEFEP----TFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEIL--------- 508
            |||..:..|..    |..|.|..::.::.|. .|.:::|:....:|..|:|..:::
Human   510 KKKGLKASFSLSLTFTSRLAPDPSLVIYAIFPSGGVVADKIQFSVEMCFDNQADLIPKLYLSLPQ 574

  Fly   509 -----TTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLR------------------------ 544
                 :.::.||..||.|:::..|.|...|..||:||||||
Human   575 VSLGFSPSQQLPGAEVELQLQAAPGSLCALRAVDESVLLLRPDRELSNRSVYGMFPFWYGHYPYQ 639

  Fly   545 ------------------------SGNDLNRDLILNNLATYSTDLV---------ILTNANINIY 576
                                    .|:...|.:|.....:..|||.         ||:||.|
Human   640 VAEYDQCPVSGPWDFPQPLIDPMPQGHSSQRSIIWRPSFSEGTDLFSFFRDVGLKILSNAKI--- 701

  Fly   577 RSSGGC-YTNPGYTNCTGSLIGRTMFKNEPTKNSGPVPIVGSTRAQASLPPVRKLFPETWLFSNI 640
            :....| :.:|.|:...|:..|..    |..::|.|:       .||....||:.||||||: ::
Human   702 KKPVDCSHRSPEYSTAMGAGGGHP----EAFESSTPL-------HQAEDSQVRQYFPETWLW-DL 754

  Fly   641 TDVGANGEYIIKETVPDTLTSWVI--------TGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLP 697
            ..:|.:|:..:..||||.:|.|..        .||.|||..||.         .|:|||:...||
Human   755 FPIGNSGKEAVHVTVPDAITEWKAMSFCTSQSRGFGLSPTVGLT---------AFKPFFVDLTLP 810

  Fly   698 YSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLW-IPAN 761
            |||.|||...:...:||||...::.:..:..|. :|:.....:...|..|.....|...| |.|.
Human   811 YSVVRGESFRLTATIFNYLKDCIRVQTDLAKSH-EYQLESWADSQTSSCLCADDAKTHHWNITAV 874

  Fly   762 TGRGISFMIRPK----------KVGLTTLKITAISKYAGDRLHQILKVEADGVQKYVNKAVLINV 816
            ....|:|.|..|          :.|...      .|...|.|.:.:.|:.:||.          |
Human   875 KLGHINFTISTKILDSNEPCGGQKGFVP------QKGRSDTLIKPVLVKPEGVL----------V 923

  Fly   817 QRLNRRSLAPPEK----TIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNM 877
            ::.:...|.|..|    ::.:|...:::..|......|.|......|::||.||.:|.|||||||
Human   924 EKTHSSLLCPKGKVASESVSLELPVDIVPDSTKAYVTVLGDIMGTALQNLDGLVQMPSGCGEQNM 988

  Fly   878 FNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAY 942
            ..|.|.|..|.||:......:||.::|..::|.|||.||.||.::||:||:|:.|..|:|||||:
Human   989 VLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGERDGNGNTWLTAF 1053

  Fly   943 VIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLLTF 1003
            |.:.|.||.|:|.||...:...|.::...|...|.:..:|.::|.:.    ...::||::|....
Human  1054 VTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAMKGGVDDEVSLTAYVTAAL 1118

  Fly  1004 FENEEYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDK-LDKLATRRG 1067
            .|..:.:.  ..::.:.:..:......:...|..|:.|...|||...:...:|.| ||:.|...|
Human  1119 LEMGKDVD--DPMVSQGLRCLKNSATSTTNLYTQALLAYIFSLAGEMDIRNILLKQLDQQAIISG 1181

  Fly  1068 DHKWWTGSDKCKSS----------EVETTSYVLLA------LLEHNISDEPKPIVDWLISKRNSN 1116
            :..:|:......|:          :||.|:|.|||      |.:..|: :...||.||..:.|:.
Human  1182 ESIYWSQKPTPSSNASPWSEPAAVDVELTAYALLAQLTKPSLTQKEIA-KATSIVAWLAKQHNAY 1245

  Fly  1117 GGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNE 1181
            |||.|:|||||.:.||.||...::..:|.|::........::...:...|....|...||.....
Human  1246 GGFSSTQDTVVALQALAKYATTAYMPSEEINLVVKSTENFQRTFNIQSVNRLVFQQDTLPNVPGM 1310

  Fly  1182 VKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSH------KGRLILGICGTYTPIAASE 1240
            ..|.|.|||...||...|||:.......:|.|:..:.|:.      ...|.|.|..:|....:|
Human  1311 YTLEASGQGCVYVQTVLRYNILPPTNMKTFSLSVEIGKARCEQPTSPRSLTLTIHTSYVGSRSS- 1374

  Fly  1241 RNKTTNMALMQVQLPSGYVCDIEPFADIEAISD-------VKRVETKNEDTEVHIYFEKLSPGDR 1298
                :|||:::|::.||       |:.:|..:.       ||:||. ..|| ::||.::|.. :.
Human  1375 ----SNMAIVEVKMLSG-------FSPMEGTNQLLLQQPLVKKVEF-GTDT-LNIYLDELIK-NT 1425

  Fly  1299 KCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY 1335
            :..|.....:..|.||||:.:::||||..:..||..|
Human  1426 QTYTFTISQSVLVTNLKPATIKVYDYYLPDEQATIQY 1462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	323/1282 (25%)
		A2M_2	859..1135	CDD:239227	98/296 (33%)
		A2M_recep	1243..1336	CDD:462226	30/100 (30%)
A2ML1	XP_011518868.1	YfaS	<123..1431	CDD:441940	352/1399 (25%)
		A2M_2	969..1264	CDD:239227	98/297 (33%)