DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep1 and CD109

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:NP_598000.2 Gene:CD109 / 135228 HGNCID:21685 Length:1445 Species:Homo sapiens


Alignment Length:1491 Identity:430/1491 - (28%)
Similarity:712/1491 - (47%) Gaps:239/1491 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ILSSTILHCV---LLSNANG-LYSVLAPKTLRSNSAYNVVVAI----HNTTRTTEVSVSLTGPSL 61
            :|::..|.||   .|:.|.| .:.|.||..:|...  ||.:.:    |..::.|..:..|...|.
Human     6 LLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGG--NVTIGVELLEHCPSQVTVKAELLKTASN 68

  Fly    62 NSRKYVDVQSM----SSKSVRFDIPKLTEGD--YELKVMG--SGGIEFQNSTKLSFAPDLNWLYI 118
            .:...::.:.:    |.|::......|...|  |||:|.|  ...|.|.|||:|||......::|
Human    69 LTVSVLEAEGVFEKGSFKTLTLPSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFI 133

  Fly   119 QSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLS 183
            |:|||.|||..:::||::.|..:.:|  ....:.|.|:|...|||:.|...:...||.|...|||
Human   134 QTDKALYKPKQEVKFRIVTLFSDFKP--YKTSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLS 196

  Fly   184 DRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPV 248
            ..|:||:|::...|.|:....: ..|.:||:|||||.:.|....:.::.::..||.|:||:.|||
Human   197 SHPILGDWSIQVQVNDQTYYQS-FQVSEYVLPKFEVTLQTPLYCSMNSKHLNGTITAKYTYGKPV 260

  Fly   249 KGHVVATI-------EGSSTEQSLPIDGEVNVEFP-----------------ISATAKRLLKITA 289
            ||.|..|.       :..:..::..|:|..|..|.                 :..::...::|..
Human   261 KGDVTLTFLPLSFWGKKKNITKTFKINGSANFSFNDEEMKNVMDSSNGLSEYLDLSSPGPVEILT 325

  Fly   290 IVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPV---------- 344
            .|||.:|.|..|.:..|...||.:.:|...:.|..:|.::......|...||:.:          
Human   326 TVTESVTGISRNVSTNVFFKQHDYIIEFFDYTTVLKPSLNFTATVKVTRADGNQLTLEERRNNVV 390

  Fly   345 ---------------------MDSSKMVNFNVLCCQVSKNF---------SASLQ---------N 370
                                 |::.:.:|:.|   ..|..|         |:.||         :
Human   391 ITVTQRNYTEYWSGSNSGNQKMEAVQKINYTV---PQSGTFKIEFPILEDSSELQLKAYFLGSKS 452

  Fly   371 SIATEHIMLPETCQSCLVTSTFDTAENIERYIYKLNKPLMIAINTKKPQLRKLLKINIISDTYLP 435
            |:|. |.:.....::.:...|.|  |||     |:..|..:.::..| :|::|        :|: 
Human   453 SMAV-HSLFKSPSKTYIQLKTRD--ENI-----KVGSPFELVVSGNK-RLKEL--------SYM- 499

  Fly   436 YFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYI-IDGVLMSDEKTVDIER 499
                 ||:||.:|      ...|:.|......|..:..|:|.:.|:|| .||.::||...:.::.
Human   500 -----VVSRGQLV------AVGKQNSTMFSLTPENSWTPKACVIVYYIEDDGEIISDVLKIPVQL 553

  Fly   500 DFENTIEILTTN-EALPRDEVSLKVK-TNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYS 562
            .|:|.|::..:. :|.|.::|||::. |.|.|.||::.||:||.|:.:.||:..:.:::.|..|:
Human   554 VFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMNASNDITMENVVHELELYN 618

  Fly   563 T-----------------DLVILTNANINIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTKNSG 610
            |                 .|.:||:||:. .....|.|.|..|..       |.|.:||     |
Human   619 TGYYLGMFMNSFAVFQECGLWVLTDANLT-KDYIDGVYDNAEYAE-------RFMEENE-----G 670

  Fly   611 PVPIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGL 675
            .:..:... :..|.|.|||.|||||::.: |::|.......:.||||::||||.|||.:|...||
Human   671 HIVDIHDF-SLGSSPHVRKHFPETWIWLD-TNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGL 733

  Fly   676 AVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTN 740
            .:|..|..::.||||||..||||||.|||..|:.:.:||||....:.||:::.|| :::.:.|:|
Human   734 GLTTTPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSD-KFDILMTSN 797

  Fly   741 KNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQ 805
            :     :.....::||.:|:..|..:.|.|||..:|...:.:||:|..|.|.:.|::.|:|:|::
Human   798 E-----INATGHQQTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIE 857

  Fly   806 KYVNKAVLINVQRLNRRSLAPPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPC 870
            |..::::|::   |....|....||:......|.:.|||.|:....|....|.:..|..|:.:|.
Human   858 KSYSQSILLD---LTDNRLQSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPY 919

  Fly   871 GCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALG 935
            |||||||.||.|:|..|.||..|.:....::.||..::..|||.||.|:|.||||||:|.:|..|
Human   920 GCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSG 984

  Fly   936 STWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHN----SHGSPLALT 996
            ||||:|:|:|.|.:|..|||||:|||.....:|...|.::|:|.:.|.|||:    .:.||:.||
Human   985 STWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLT 1049

  Fly   997 SFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQS-NEPYDLAIAALALSLARNRNAYKVLDKLD 1060
            ::::.:.....:|.|...  :..::.|:.:|..:. ::.|.||:...|||...:..|.:.|:.|.
Human  1050 AYIVTSLLGYRKYQPNID--VQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNMLT 1112

  Fly  1061 KLATRRGDHKWWTGSD-------KCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGG 1118
            ..|.:.|..::|..|:       :.:|.::|..:|.||:......:.|..||:.||..:|||.||
Human  1113 WRAEQEGGMQFWVSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGG 1177

  Fly  1119 FVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKEN-------EFKVQTH-QL 1175
            |.|:|||.|.:.||:::...              :|.::.:::||...       :|.:.|| :|
Human  1178 FASTQDTTVALKALSEFAAL--------------MNTERTNIQVTVTGPSSPSPVKFLIDTHNRL 1228

  Fly  1176 PENTNE--------VKLLAKGQGRAQVQLTYRYNVATK---------EARPSFKLTTTVK--KSH 1221
            ...|.|        |.:.|.|.|.|..||...|||...         :.:.:|.|...||  |..
Human  1229 LLQTAELAVVQPTAVNISANGFGFAICQLNVVYNVKASGSSRRRRSIQNQEAFDLDVAVKENKDD 1293

  Fly  1222 KGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKNEDTEV 1286
            ...:.|.:|.:::....|      .||||:|.|.||::.   |...|.....||:||  .:..::
Human  1294 LNHVDLNVCTSFSGPGRS------GMALMEVNLLSGFMV---PSEAISLSETVKKVE--YDHGKL 1347

  Fly  1287 HIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYH--VDTSLCDIC 1345
            ::|.:.::. .:.|:.:.|:....|:|.:.:.|.:.|||...|.|...|:  |..|.||:|
Human  1348 NLYLDSVNE-TQFCVNIPAVRNFKVSNTQDASVSIVDYYEPRRQAVRSYNSEVKLSSCDLC 1407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 31/84 (37%)
A2M_N_2 411..542 CDD:285005 38/133 (29%)
A2M 634..726 CDD:278630 42/91 (46%)
A2M_2 859..1135 CDD:239227 105/287 (37%)
A2M_comp 910..1135 CDD:284982 85/236 (36%)
A2M_recep 1245..1335 CDD:284981 25/89 (28%)
CD109NP_598000.2 YfaS <66..>1000 CDD:225248 295/992 (30%)
A2M_N 130..221 CDD:280081 31/93 (33%)
A2M_N_2 470..596 CDD:285005 43/153 (28%)
Bait region (approximate). /evidence=ECO:0000250 593..702 34/123 (28%)
A2M 693..782 CDD:278630 40/89 (45%)
A2M_2 907..1194 CDD:239227 105/288 (36%)
A2M_comp 959..1196 CDD:284982 85/238 (36%)
A2M_recep 1311..1395 CDD:284981 26/95 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149962
Domainoid 1 1.000 84 1.000 Domainoid score I8230
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 613 1.000 Inparanoid score I912
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45959
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 1 1.000 - - FOG0002157
OrthoInspector 1 1.000 - - otm40305
orthoMCL 1 0.900 - - OOG6_100452
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.810

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