Protein Alignment Tep1 and C4b

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_006523594.1
• Gene: C4b / 12268
• MGIID: 88228
• Length: 1758
• Species: Mus musculus
• Alignment Length: 1542
• Identity: 352/1542 - (22%)
• Similarity: 619/1542 - (40%)
• Gaps: 387/1542 - (25%)

  Fly   107 LSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKP 171
            |.|:.....:::|:|:..|.||.::::||..||:..||:.....|.:|...| ..::|  |:|..
Mouse   130 LLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDFLTITVENSHG-LRVLK--KEIFT 191

  Fly   172 AKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLTAK----NVAAS 230
            :..::.....:.|....|.|.::|...|  |...:....|.|||:|.|||.:...|    .|.::
Mouse   192 STSIFQDAFTIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSN 256

  Fly   231 AGYIRATIKARYTFKKPVKGHVVAT-------------IEGSSTEQSLPIDGEVNV-----EFPI 277
            :..|:..|:|||.:.|||:| |..|             :.|..|:..| ::|..::     :|.
Mouse   257 SDEIQLDIQARYIYGKPVQG-VAYTRFALMDEQGKRTFLRGLETQAKL-VEGRTHISISKDQFQ- 318

  Fly   278 SATAK-----------RLLKITAIVTE--------ELTDIKHNGTAYVTVHQHRHKLEDLFWPTH 323
            :|..|           ||...||::..        |||..:...:|: ::...|.|       .|
Mouse   319 AALDKINIGVRDLEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAF-SLDLSRTK-------RH 375

  Fly   324 YRPGVSSEFKTVVRNLDGS-----PVMDSSKMV---NFNVLCCQVSKNFSASLQNSIATEHIMLP 380
            ..||.....:.:|:.:.||     ||..|:.:|   :..||..|.|.|....:..|..    :.|
Mouse   376 LVPGAHFLLQALVQEMSGSEASNVPVKVSATLVSGSDSQVLDIQQSTNGIGQVSISFP----IPP 436

  Fly   381 ETCQSCLVTSTFDTAENIERYIYKLN----------KPLMIAINTKKPQ-----LRKLLKINIIS 430
            ...:..|:.|.......|.|...:..          :||    :.:.|.     :..|..:.|.:
Mouse   437 TVTELRLLVSAGSLYPAIARLTVQAPPSRGTGFLSIEPL----DPRSPSVGDTFILNLQPVGIPA 497

  Fly   431 DTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI----EFEPTFALVPQATIFVHYIIDGVLMSD 491
            .|:..|:.: :::||.| :::.:|.::...|..:    :..|:|..|   ..|.|   .|..:::
Mouse   498 PTFSHYYYM-IISRGQI-MAMGREPRKTVTSVSVLVDHQLAPSFYFV---AYFYH---QGHPVAN 554

  Fly   492 EKTVDIE-RDFENTIEILT--TNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLL--RSGNDLNR 551
            ...::|: ||.|..:::..  ..|....|.:.|:::|:..:.|.|..||.::..:  ||...|:.
Mouse   555 SLLINIQSRDCEGKLQLKVDGAKEYRNADMMKLRIQTDSKALVALGAVDMALYAVGGRSHKPLDM 619

  Fly   552 DLILNNLATYSTD---------LVILTNA-----------------------------NINIYRS 578
            ..:...:.:|:..         |.:..:|                             |:|..::
Mouse   620 SKVFEVINSYNVGCGPGGGDDALQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFQKA 684

  Fly   579 SG---GCYTNPGYTNCTGSLIGRTMFKNEPTKNSGPVPIV------------------GSTRAQA 622
            ..   |.|::|....|....:.:...|....:.:..||..                  ..||:||
Mouse   685 VSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDLRRNQTRSQA 749

  Fly   623 SLPP------------------VRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSL 669
            .|..                  ||..|||.||: .:..|  :...::...:||::|:|.|.|.||
Mouse   750 HLARNNHNMLQEEDLIDEDDILVRTSFPENWLW-RVEPV--DSSKLLTVWLPDSMTTWEIHGVSL 811

  Fly   670 SPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYE 734
            |...||.|.: |:|:|||:.|.:...||.|::|.|...:..:::|||..||...|.:...:|..
Mouse   812 SKSKGLCVAK-PTRVRVFRKFHLHLRLPISIRRFEQFELRPVLYNYLNDDVAVSVHVTPVEGLC- 874

  Fly   735 FIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKY-AGDRLHQILK 798
                       ...|....:.:.:||.:.|.::|.:.|.......||:.|...: .||.:.:||:
Mouse   875 -----------LAGGGMMAQQVTVPAGSARPVAFSVVPTAAANVPLKVVARGVFDLGDAVSKILQ 928

  Fly   799 VEADGVQKYVNKAVLI-NVQRLNR--RSLAPPEKT--IIIEKAD--NVIEGSETVEFEVCGTSQA 856
            :|.:|.   :::..|: |:..||.  |:|..|..:  .|:...|  :::..:.:...|..|:..|
Mouse   929 IEKEGA---IHREELVYNLDPLNNLGRTLEIPGSSDPNIVPDGDFSSLVRVTASEPLETMGSEGA 990

  Fly   857 PQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQ------EIENKAKRYVETGYQIE 915
            .....:..|:.||.||.||.|....|::.|.:||   :|.:|      |.::.|...::.||...
Mouse   991 LSPGGVASLLRLPQGCAEQTMIYLAPTLTASNYL---DRTEQWSKLSPETKDHAVDLIQKGYMRI 1052

  Fly   916 LNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKE 980
            ..:::|||||.||...|:  ||||||:|::....|.:.:......|.....:|:::|..||.|.:
Mouse  1053 QQFRKNDGSFGAWLHRDS--STWLTAFVLKILSLAQEQVGNSPEKLQETASWLLAQQLGDGSFHD 1115

  Fly   981 LGMVIHNSH-----GS--PLALTSFVL------LTFFENEEYMPKYKHV---IDRAVEFV----- 1024
            ...|||.:.     ||  .:|||:||:      |..|::::.......|   |.:|..|:
Mouse  1116 PCPVIHRAMQGGLVGSDETVALTAFVVIALHHGLDVFQDDDAKQLKNRVEASITKANSFLGQKAS 1180

  Fly  1025 --VTEVHQSNEPYDLAIAALALSLARN----RNAYKVLDKLDKLATRRGDHKWW---TGS-DK-- 1077
              :...|.:      ||.|.||:|.:.    ||.  ..:.|..:|...|:|.:|   .|| ||
Mouse  1181 AGLLGAHAA------AITAYALTLTKASEDLRNV--AHNSLMAMAEETGEHLYWGLVLGSQDKVV 1237

  Fly  1078 ---------------CKSSEVETTSYVLLALL----EHNISDEPKPIVDWLISKRNSNGGFVSSQ 1123
                           ..:..:|||:|.||.||    :..::|:   ...||..:.:.:|.|.|:|
Mouse  1238 LRPTAPRSPTEPVPQAPALWIETTAYALLHLLLREGKGKMADK---AASWLTHQGSFHGAFRSTQ 1299

  Fly  1124 DTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFK--VQTHQLPENTNEVKLL- 1185
            ||||.:.||:.|.:.||.:.|             |.:.||..:..:  ::||.|..|.::||.|
Mouse  1300 DTVVTLDALSAYWIASHTTEE-------------KALNVTLSSMGRNGLKTHGLHLNNHQVKGLE 1351

  Fly  1186 --------------AKGQGRAQVQLTYRYNV------ATKEARPSFKLTTTVK------------ 1218
                          .:|..:..:::...|||      ..::.:...|:|..|:
Mouse  1352 EELKFSLGSTISVKVEGNSKGTLKILRTYNVLDMKNTTCQDLQIEVKVTGAVEYAWDANEDYEDY 1416

  Fly  1219 -------------------------------------KSHKGRLILGICGTYTPIAASERNKTTN 1246
                                                 :..:.|:...:|     |..:.:...:.
Mouse  1417 YDMPAADDPSVPLQPVTPLQLFEGRRSRRRREAPKVVEEQESRVQYTVC-----IWRNGKLGLSG 1476

  Fly  1247 MALMQVQLPSGY---VCDIEPFADIEAISD--VKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAI 1306
            ||:..:.|.||:   ..|:|   .:.::||  |...||  :...|.:||:.: |..|:|:...|.
Mouse  1477 MAIADITLLSGFHALRADLE---KLTSLSDRYVSHFET--DGPHVLLYFDSV-PTTRECVGFGAS 1535

  Fly  1307 YTHAVANLKPSWVRLYDYYATERSATEFYHVDTS---LCDICHGNEC 1350
            ....|..::||...|||||:.:...:.||...|.   |..:|.|:.|
Mouse  1536 QEVVVGLVQPSSAVLYDYYSPDHKCSVFYAAPTKSQLLATLCSGDVC 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	307/1317 (23%)
		A2M_2	859..1135	CDD:239227	95/333 (29%)
		A2M_recep	1243..1336	CDD:462226	28/97 (29%)
C4b	XP_006523594.1	YfaS	<136..1327	CDD:441940	298/1268 (24%)
		A2M	779..867	CDD:459711	32/91 (35%)
		TED_complement	978..1311	CDD:462227	98/348 (28%)
		A2M_recep	1475..1564	CDD:462226	27/94 (29%)
		NTR_like	1582..1736	CDD:470599	1/1 (100%)