DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and C3

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_033908.2	Gene:	C3 / 12266	MGIID:	88227	Length:	1663	Species:	Mus musculus

Alignment Length:	1619	Identity:	399/1619 - (24%)
Similarity:	654/1619 - (40%)	Gaps:	387/1619 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLWLILSSTILHCVLLSNANG--LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVS-------- 55
            :|.|:|:|:.|       |.|  :||::.|..||..|...:|:..|:......|:|:
Mouse    11 VLLLLLASSPL-------ALGIPMYSIITPNVLRLESEETIVLEAHDAQGDIPVTVTVQDFLKRQ 68

  Fly    56 --------LTGPSLNSRKYVDVQSMSSKSVRFDIPKLTEG-DYELKVMGSGGIEFQNSTKLSFAP 111
                    |||.|.:.|. |.::..:||....|    .|| .|...|...|....:.:..:||
Mouse    69 VLTSEKTVLTGASGHLRS-VSIKIPASKEFNSD----KEGHKYVTVVANFGETVVEKAVMVSF-- 126

  Fly   112 DLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVY 176
            ...:|:||:||..|.||..:.:|:..:|.|..|......|.||..||    |...:||..:...:
Mouse   127 QSGYLFIQTDKTIYTPGSTVLYRIFTVDNNLLPVGKTVVILIETPDG----IPVKRDILSSNNQH 187

  Fly   177 SGELQLS-DRPVL---GNWTVTATVQDEGK--VTNVLVVDKYVVPKFEVVVLTAKNVAASAGYI- 234
             |.|.|| :.|.|   |.|.:.|..:...|  .:....|.:||:|.|||.|...:...    ||
Mouse   188 -GILPLSWNIPELVNMGQWKIRAFYEHAPKQIFSAEFEVKEYVLPSFEVRVEPTETFY----YID 247

  Fly   235 -----RATIKARYTFKKPVKG--HVVATIEGSSTEQSLPIDGEVNVEFPISAT------------ 280
                 ..:|.|::.:.|.|.|  .|:..::          ||:..:....|.|
Mouse   248 DPNGLEVSIIAKFLYGKNVDGTAFVIFGVQ----------DGDKKISLAHSLTRVVIEDGVGDAV 302

  Fly   281 -AKRLL-------KITAIVTEEL----TDIKHNGTAYVTVHQ-------HRHKLEDLFWPTHYRP 326
             .:::|       ...|:|.:.|    |.|.|:|:..|...:       ..:::.....|..::|
Mouse   303 LTRKVLMEGVRPSNADALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKP 367

  Fly   327 GVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQN-------------------SI 372
            .:..:....|.|.||||   :||     ||......|..|..|:                   ::
Mouse   368 AMPFDLMVFVTNPDGSP---ASK-----VLVVTQGSNAKALTQDDGVAKLSINTPNSRQPLTITV 424

  Fly   373 ATEHIMLPETCQSCLVTST-----FDTAENIERYIYKLNKPLMIAINTKKPQLRKLLKINIISD- 431
            .|:...|||:.|:   |.|     :.|..|...|::     |.::....||.....:..::.:|
Mouse   425 RTKKDTLPESRQA---TKTMEAHPYSTMHNSNNYLH-----LSVSRMELKPGDNLNVNFHLRTDP 481

  Fly   432 ---TYLPYFILTVVARGNIVLSLFQEMKEKKKSQEI-------EFEPTFALVPQATIFVHYIIDG 486
               ..:.|:...|:.:|.: |...::::|..:...:       ||.|:|.||      .:|.:.|
Mouse   482 GHEAKIRYYTYLVMNKGKL-LKAGRQVREPGQDLVVLSLPITPEFIPSFRLV------AYYTLIG 539

  Fly   487 V-----LMSDEKTVDIERDFENTIEIL---TTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLL 543
            .     :::|...||::.....|:.:.   ..|...|..:.:|:::.|..:.|||:.||:.|.:|
Mouse   540 ASGQREVVADSVWVDVKDSCIGTLVVKGDPRDNHLAPGQQTTLRIEGNQGARVGLVAVDKGVFVL 604

  Fly   544 RSGNDLNRDLILNNLATYSTDLVILTNANINIYRSSG---------------------------- 580
            ...|.|.:..|.:          ::..|:|.....||
Mouse   605 NKKNKLTQSKIWD----------VVEKADIGCTPGSGKNYAGVFMDAGLAFKTSQGLQTEQRADL 659

  Fly   581 -----------------------GCYTNPGYTNC----------------TGSLI--GRTMFK-- 602
                                   |.||:.|...|                ...||  |....|
Mouse   660 ECTKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMRYSCQRRARLITQGENCIKAF 724

  Fly   603 ----NEPTK---NSGPVPIVGSTRAQAS---LPP----VRKLFPETWLFS--NITDVGANG--EY 649
                |..||   ......::|..|::..   :|.    .|..||::||::  .:.:...||  ..
Mouse   725 IDCCNHITKLREQHRRDHVLGLARSELEEDIIPEEDIISRSHFPQSWLWTIEELKEPEKNGISTK 789

  Fly   650 IIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFN 714
            ::...:.|::|:|.|...|||.:.|:.|. :|..|||.|.|||...|||||.|.|.:.|..::||
Mouse   790 VMNIFLKDSITTWEILAVSLSDKKGICVA-DPYEIRVMQDFFIDLRLPYSVVRNEQVEIRAVLFN 853

  Fly   715 YLGM-DVKAKV-LMDNSDGQYEFIE-TTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVG 776
            |... ::|.:| |:.|.    .|.. .|.||        |..:|:.||..:...:.::|.|.|:|
Mouse   854 YREQEELKVRVELLHNP----AFCSMATAKN--------RYFQTIKIPPKSSVAVPYVIVPLKIG 906

  Fly   777 LTTLKITA--ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEK-------TII 832
            ...:::.|  .:.:..|.:.:.|||..:|::  :||.|.|:.        ..|||       .:.
Mouse   907 QQEVEVKAAVFNHFISDGVKKTLKVVPEGMR--INKTVAIHT--------LDPEKLGQGGVQKVD 961

  Fly   833 IEKAD-------------NVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSI 884
            :..||             .:::||..|:.    ...|...|.|..|:..|.|||||||....|::
Mouse   962 VPAADLSDQVPDTDSETRIILQGSPVVQM----AEDAVDGERLKHLIVTPAGCGEQNMIGMTPTV 1022

  Fly   885 LALSYLKAKNRQDQ---EIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRS 946
            :|:.||....:.::   |...:|...::.||..:|.:|:...:::|:.....  ||||||||::.
Mouse  1023 IAVHYLDQTEQWEKFGIEKRQEALELIKKGYTQQLAFKQPSSAYAAFNNRPP--STWLTAYVVKV 1085

  Fly   947 FHQAAKYIDIDKNVLVAGLDFLV-SRQSTDGKFKELGMVIH--------NSHGSPLALTSFVLLT 1002
            |..||..|.||.:||...:.:|: .:|..||.|:|.|.|||        |:..:.::||:|||:.
Mouse  1086 FSLAANLIAIDSHVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNAKEADVSLTAFVLIA 1150

  Fly  1003 FFEN----EEYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLD--- 1060
            ..|.    |..:......|::|.|::.........||.:|||..||:|         ::||:
Mouse  1151 LQEARDICEGQVNSLPGSINKAGEYIEASYMNLQRPYTVAIAGYALAL---------MNKLEEPY 1206

  Fly  1061 --KLATRRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQ 1123
              |......|...|...|: :...||.|||.|||||.....|...|:|.||..:|...||:.|:|
Mouse  1207 LGKFLNTAKDRNRWEEPDQ-QLYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQ 1270

  Fly  1124 DTVVGIMALTKY--ELQSHASTEAIDIEFWHL--NEDKKHVRVTKENEFKVQTHQLPENTNEVKL 1184
            .|.:...||.:|  ::..|.... :|:.| ||  .......|:..||...:::.:..:| ....|
Mouse  1271 ATFMVFQALAQYQTDVPDHKDLN-MDVSF-HLPSRSSATTFRLLWENGNLLRSEETKQN-EAFSL 1332

  Fly  1185 LAKGQGRA--QVQLTYRYNVATKEARPSFKLTTTVK---------KSHKGRLILGICGTYTPIAA 1238
            .|||:||.  .|...|...:.:|.....|.|..:::         :..|..:.|.||..|.
Mouse  1333 TAKGKGRGTLSVVAVYHAKLKSKVTCKKFDLRVSIRPAPETAKKPEEAKNTMFLEICTKYL---- 1393

  Fly  1239 SERNKTTNMALMQVQLPSGYVCDIEPFADIEAI-SDVKRVETK--------NEDTEVHIYFEKLS 1294
              .:....|:::.:.:.:|:..|.:   |:|.: |.|.|..:|        |::|.: ||.||:|
Mouse  1394 --GDVDATMSILDISMMTGFAPDTK---DLELLASGVDRYISKYEMNKAFSNKNTLI-IYLEKIS 1452

  Fly  1295 PGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHV---DTSLCDICHGNEC 1350
            ..:..|||.:......|..::|..|::|.||..|.|.|.|||.   |..|..:||...|
Mouse  1453 HTEEDCLTFKVHQYFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHSEMC 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	29/88 (33%)
		A2M_N_2	411..542	CDD:285005	30/149 (20%)
		A2M	634..726	CDD:278630	34/97 (35%)
		A2M_2	859..1135	CDD:239227	96/296 (32%)
		A2M_comp	910..1135	CDD:284982	79/242 (33%)
		A2M_recep	1245..1335	CDD:284981	28/98 (29%)
C3	NP_033908.2	A2M_N	130..225	CDD:280081	30/99 (30%)
		A2M_N_2	458..603	CDD:285005	31/151 (21%)
		ANATO	678..747	CDD:237984	13/68 (19%)
		A2M	770..866	CDD:278630	34/96 (35%)
		complement_C3_C4_C5	996..1282	CDD:239226	96/297 (32%)
		A2M_comp	1051..1282	CDD:284982	79/242 (33%)
		A2M_recep	1398..1493	CDD:284981	28/98 (29%)
		NTR_complement_C3	1513..1661	CDD:239638
		Interaction with CFP/properdin. /evidence=ECO:0000250\|UniProtKB:P01024	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.800