Protein Alignment Tep1 and Pzp

DIOPT Version :9

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_031402.3
• Gene: Pzp / 11287
• MGIID: 87854
• Length: 1495
• Species: Mus musculus
• Alignment Length: 1570
• Identity: 400/1570 - (25%)
• Similarity: 669/1570 - (42%)
• Gaps: 306/1570 - (19%)

  Fly     1 MLWLILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRK 65
            :|:|:|...    ...:.|...|.||.|..:.|.......|::::...|..:|::|. .::...|
Mouse    13 LLFLLLPRD----ATTATAKPQYVVLVPSEVYSGVPEKACVSLNHVNETVMLSLTLE-YAMQQTK 72

  Fly    66 YVDVQSMSSKSVRFDIPKLTEGD--------YELKVMGSGGIE-FQNSTKLSFAPDLNWLYIQSD 121
            .:..|::...|. :..|....|.        .|:|    |..: |.....:......:.:::|:|
Mouse    73 LLTDQAVDKDSF-YCSPFTISGSPLPYTFITVEIK----GPTQRFIKKKSIQIIKAESPVFVQTD 132

  Fly   122 KATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRP 186
            |..||||..::|||:.:|.:.||.....|: :.|....:|.|..|::|..|.|::.....||..|
Mouse   133 KPIYKPGQIVKFRVVSVDISFRPLNETFPV-VYIETPKRNRIFQWQNIHLAGGLHQLSFPLSVEP 196

  Fly   187 VLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGH 251
            .||.:.|........|:.:...|.:||:|||||::...|.:|.....:..|....||:.|||.|.
Mouse   197 ALGIYKVVVQKDSGKKIEHSFEVKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGL 261

  Fly   252 VVATI--------EGSSTEQSLPIDGEVNVEFPISATAKRLLK----------------ITAIVT 292
            |...:        .....:.|:.|..|.:.:.......::::|                :.|.:.
Mouse   262 VTLRVCRKYSRYRSTCHNQNSMSICEEFSQQADDKGCFRQVVKTKVFQLRQKGHDMKIEVEAKIK 326

  Fly   293 EELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPV------------- 344
            ||.|.|:..|.....:.....||:.....|:||||:....:.::.:..|.|:
Mouse   327 EEGTGIELTGIGSCEIANALSKLKFTKVNTNYRPGLPFSGQVLLVDEKGKPIPNKNITSVVSPLG 391

  Fly   345 ------MDSSKMVNFNVLCCQVSKNFSASL--------QNSIATEHIMLPE--TCQSCLVTSTFD 393
                  .|...:.|.::    .:.||:|..        ||.:..::..|.|  |......|..|.
Mouse   392 YLSIFTTDEHGLANISI----DTSNFTAPFLRVVVTYKQNHVCYDNWWLDEFHTQADHSATLVFS 452

  Fly   394 TAENIERYI-YKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVVARGNI------VLSL 451
            .:::   || .:|....:....|::.::..||..:|:.:.....|...:.|||:|      ||||
Mouse   453 PSQS---YIQLELVFGTLACGQTQEIRIHYLLNEDIMKNEKDLTFYYLIKARGSIFNLGSHVLSL 514

  Fly   452 FQEMKEKKKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEAL 514
            .|...:...|..|:.||  .:.|:|.:.::.|: :..|::|.:..:||:.|.|.:.: ..:.::|
Mouse   515 EQGNMKGVFSLPIQVEP--GMAPEAQLLIYAILPNEELVADAQNFEIEKCFANKVNLSFPSAQSL 577

  Fly   515 PRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTDLVILTNANINIYRSS 579
            |..:..||||..|.|...|..||||||||:....|:...|.|.|...:......   .:.:|:..
Mouse   578 PASDTHLKVKAAPLSLCALTAVDQSVLLLKPEAKLSPQSIYNLLPGKTVQGAFF---GVPVYKDH 639

  Fly   580 GGC------------YT---------------NPGYTNCTGSLIGRTMFKNE----PTKN----- 608
            ..|            ||               :.|....|.|.|.:..|..|    |...
Mouse   640 ENCISGEDITHNGIVYTPKHSLGDNDAHSIFQSVGINIFTNSKIHKPRFCQEFQHYPAMGGVAPQ 704

  Fly   609 ------SGP--------VPIVG------STRAQASLPPVRKLFPETWLFSNI-TDVGANGEYIIK 652
                  |||        ||::|      ..:.......|||.|||||::..: .||..:||..:|
Mouse   705 ALAVAASGPGSSFRAMGVPMMGLDYSDEINQVVEVRETVRKYFPETWIWDLVPLDVSGDGELAVK 769

  Fly   653 ETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLG 717
              ||||:|.|..:.|.||..:||.::...| ::.|||||:...|||||.|||...:...|.||:.
Mouse   770 --VPDTITEWKASAFCLSGTTGLGLSSTIS-LQAFQPFFLELTLPYSVVRGEAFTLKATVLNYMS 831

  Fly   718 MDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKI 782
            ..::.:|.::.|. .:..:.......|..:.|..||...|           .:.||.:|......
Mouse   832 HCIQIRVDLEISP-DFLAVPVGGHENSHCICGNERKTVSW-----------AVTPKSLGEVNFTA 884

  Fly   783 TAIS----KYAGDRLHQI------------LKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTI 831
            ||.:    :..|::|.::            :.||.:|::|         .|..|  :|..|:.|.
Mouse   885 TAEALQSPELCGNKLTEVPALVHKDTVVKSVIVEPEGIEK---------EQTYN--TLLCPQDTE 938

  Fly   832 I-----IEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLK 891
            :     :|...||:|||......|.|......:::|.:|:.:|.|||||||..|||:|..|:||.
Mouse   939 LQDNWSLELPPNVVEGSARATHSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNYLN 1003

  Fly   892 AKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQH---DALGSTWLTAYVIRSFHQAAKY 953
            ...:..:.|::||..|:.:|||.:|||:.:|||:|.:|.|   :..|:|||||:|:::|.||..:
Mouse  1004 ETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNHGGGNTPGNTWLTAFVLKAFAQAQSH 1068

  Fly   954 IDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLLTFFENEEYMPKYK 1014
            |.|:|..:....::|..:|..:|.|::.|.:::|:.    ...:.|::::.:...|..  :|...
Mouse  1069 IFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMP--LPVTH 1131

  Fly  1015 HVIDRA---VEFVVTEVHQSNEP--YDLAIAALALSLARNR-NAYKVLDKLDKLATRRGDHKWWT 1073
            ..:..|   :|.....:.||.|.  |..|:.|.|.:||.|: ...::|:.|:|.|.:..|...|.
Mouse  1132 SAVRNALFCLETAWASISQSQESHVYTKALLAYAFALAGNKAKRSELLESLNKDAVKEEDSLHWQ 1196

  Fly  1074 G-------------SDKCKSSEVETTSYVLLALLEHNISDEPKP--------------IVDWLIS 1111
            .             ..:..|:|||.|:|||||.|   .|:..:|              ||.|:..
Mouse  1197 RPGDVQKVKALSFYQPRAPSAEVEMTAYVLLAYL---TSESSRPTRDLSSSDLSTASKIVKWISK 1258

  Fly  1112 KRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKE----------- 1165
            ::||:|||.|:|||||.:.||:||    .|:|         ....:|.|.||.|
Mouse  1259 QQNSHGGFSSTQDTVVALQALSKY----GAAT---------FTRSQKEVLVTIESSGTFSKTFHV 1310

  Fly  1166 ---NEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNV-ATKEARPSFKLTTTV------KKS 1220
               |...:|..:||:..........|.|...:|.:.:||: ...:.:..|.|....      |..
Mouse  1311 NSGNRLLLQEVRLPDLPGNYVTKGSGSGCVYLQTSLKYNILPVADGKAPFALQVNTLPLNFDKAG 1375

  Fly  1221 HKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVE-TKNEDT 1284
            ......:.|..:||    .|| .::||.::.|::.||:: .::|  .::.:.|...:: |:....
Mouse  1376 DHRTFQIRINVSYT----GER-PSSNMVIVDVKMVSGFI-PMKP--SVKKLQDQPNIQRTEVNTN 1432

  Fly  1285 EVHIYFEKLSPGDRKCLTLEAI-YTHA------VANLKPSWVRLYDYYATERSATEFYHVDTSLC 1342
            .|.||.||        ||.:.: ::.|      |.||||:.:::||||.|:....|.|....|
Mouse  1433 HVLIYIEK--------LTNQTLGFSFAVEQDIPVKNLKPAPIKVYDYYETDEFTVEEYSAPFS-- 1487

  Fly  1343 DICHGNECGN 1352
               .|:|.||
Mouse  1488 ---DGSEQGN 1494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	27/84 (32%)
		A2M_N_2	411..542	CDD:285005	41/138 (30%)
		A2M	634..726	CDD:278630	36/92 (39%)
		A2M_2	859..1135	CDD:239227	102/315 (32%)
		A2M_comp	910..1135	CDD:284982	81/264 (31%)
		A2M_recep	1245..1335	CDD:284981	27/97 (28%)
Pzp	NP_031402.3	A2M_N	127..219	CDD:280081	28/92 (30%)
		A2M_N_2	460..605	CDD:285005	42/146 (29%)
		Bait region	686..744		9/57 (16%)
		A2M	750..840	CDD:278630	36/92 (39%)
		A2M_2	970..1282	CDD:239227	102/316 (32%)
		A2M_comp	1022..1284	CDD:284982	83/270 (31%)
		A2M_recep	1395..1482	CDD:284981	27/97 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840011
Domainoid	1	1.000	227	1.000	Domainoid score	I2492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750