Protein Alignment Tep1 and LOC110384692

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001338929.1
• Gene: LOC110384692 / 110384692
• -ID: -
• Length: 1744
• Species: Homo sapiens
• Alignment Length: 1679
• Identity: 372/1679 - (22%)
• Similarity: 624/1679 - (37%)
• Gaps: 422/1679 - (25%)

  Fly     1 MLW-LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEV--SVSLTGPSLN 62
            :|| ||.:|:..   .||.......:.:|..:......:|.|.:.:..|...|  ||.|..||.|
Human     3 LLWGLIWASSFF---TLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRN 64

  Fly    63 SRKYVDVQSMSSKSVRFDIPKLTEGDY-------ELKVMGSGGI-------EFQ----------- 102
            :         ...|.:.|....:|.|:       .||...|.|:       |.|
Human    65 N---------VPCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDS 120

  Fly   103 -------NSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQ 160
                   ....|.|:.....|::|:|:..|.||.::::||..||:..||:.....:.:|...|
Human   121 LSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHG-- 183

  Fly   161 NLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLT 223
             |....|::.....::..:..:.|....|.|.::|...|  |...:....|.|||:|.|||.:..
Human   184 -LRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITP 247

  Fly   224 AK----NVAASAGYIRATIKARYTFKKPVKGHVVATI-------EGSST------EQSLPIDGEV 271
            .|    .|......::..|:|||.:.|||:|  ||.:       :|..|      .|:..::|:.
Human   248 GKPYILTVPGHLDEMQLDIQARYIYGKPVQG--VAYVRFGLLDEDGKKTFFRGLESQTKLVNGQS 310

  Fly   272 NVEFPISATAKRLLKITAIVTEELTDIKHNGTAYVTVHQ--HRHKLEDLFW-------------- 320
            ::....:.....|.|:...:| :|..::....|.:..:.  ...:.|...|
Human   311 HISLSKAEFQDALEKLNMGIT-DLQGLRLYVAAAIIEYPGGEMEEAELTSWYFVSSPFSLDLSKT 374

  Fly   321 PTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVL-------CCQVSKNFSASLQNSIATEHIM 378
            ..|..||.....:.:||.:.|||.......|:..|.       ...:.:|...|.|.||.   |:
Human   375 KRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDIQQNTDGSGQVSIP---II 436

  Fly   379 LPETCQSC-LVTSTFDTAENIERY-----------IYKLNKPLMIAINTKKPQLRKLLKINI--- 428
            :|:|.... |..|.......|.|.           ...:.:|     :::.|::...|.:|:
Human   437 IPQTISELQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERP-----DSRPPRVGDTLNLNLRAV 496

  Fly   429 -ISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDGVLMSDE 492
             ...|:..|:.: :::||.||   |...:.|:....:.......|.|.......|......:::.
Human   497 GSGATFSHYYYM-ILSRGQIV---FMNREPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHPVANS 557

  Fly   493 KTVDIERD-FENTIEILTTNEALPR--DEVSLKVKTNPHSFVGLLGVDQSVLLL--RSGNDLNRD 552
            ..||::.. .|..:|:........|  :.|.|.::|:..:.|.|..:|.::...  :|...||..
Human   558 LRVDVQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNMG 622

  Fly   553 LILNNLATY---------STDLVILTNA-----------------------------NINIYRSS 579
            .:...:.:|         .:.|.:...|                             |:|..::.
Human   623 KVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVNFQKAI 687

  Fly   580 G---GCYTNP--------GYT------------------NCTGSLIGRTMFKNEPTKNSGPVPIV 615
            .   |.|.:|        |.|                  :|....:....|.....|.|......
Human   688 NEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCCQFAESLRKKSRDKGQA 752

  Fly   616 GSTRAQASLP----------PVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLS 670
            |..||...|.          |||..|||.||:...|   .:...|:...:||:||:|.|.|.|||
Human   753 GLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVET---VDRFQILTLWLPDSLTTWEIHGLSLS 814

  Fly   671 PQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEF 735
            ...||.|. .|.::|||:.|.:...||.||:|.|.:.:..:::|||..::...|.:...:|..
Human   815 KTKGLCVA-TPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLC-- 876

  Fly   736 IETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKY---AGDRLHQIL 797
                      ...|....:.:.:||.:.|.::|.:.|......:||:.|...:   .||.:.::|
Human   877 ----------LAGGGGLAQQVLVPAGSARPVAFSVVPTAAAAVSLKVVARGSFEFPVGDAVSKVL 931

  Fly   798 KVEADGVQKYVNKAVLINVQRLN-----RRSLAPPEKT--IIIEKAD--NVIEGSETVEFEVCGT 853
            ::|.:|.   :::..|  |..||     .|:|..|..:  .:|...|  :.:..:.:...:..|:
Human   932 QIEKEGA---IHREEL--VYELNPLDHRGRTLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGS 991

  Fly   854 SQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQ----DQEIENKAKRYVETGYQI 914
            ..|.....:..|:.||.|||||.|....|::.|..||. |..|    ..|.::.|...::.||..
Human   992 EGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLD-KTEQWSTLPPETKDHAVDLIQKGYMR 1055

  Fly   915 ELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFK 979
            ...:::.|||::||...|:  ||||||:|::....|.:.:......|....::|:|:|..||.|:
Human  1056 IQQFRKADGSYAAWLSRDS--STWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQ 1118

  Fly   980 ELGMVIHNS-------HGSPLALTSFVL------LTFFENEEYMPKYKHV---IDRAVEFV---- 1024
            :...|:..|       :...:|||:||.      |..|::|...|..:.|   |.:|..|:
Human  1119 DPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANSFLGEKA 1183

  Fly  1025 ---VTEVHQSNEPYDLAIAALALSL----------ARNRNAYKVLDKLDKLATRRGDHKWW---T 1073
               :...|.:      ||.|.||:|          |.|        .|..:|...||:.:|   |
Human  1184 SAGLLGAHAA------AITAYALTLTKAPVDLLGVAHN--------NLMAMAQETGDNLYWGSVT 1234

  Fly  1074 GSDKCKSSE------------------VETTSYVLLALLEH----NISDEPKPIVDWLISKRNSN 1116
            ||.....|.                  :|||:|.||.||.|    .::|:   ...||..:.:..
Human  1235 GSQSNAVSPTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEGKAEMADQ---AAAWLTRQGSFQ 1296

  Fly  1117 GGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNE 1181
            |||.|:||||:.:.||:.|.:.||.:.|.      .||..   :..|..|.||  :|.|..|..:
Human  1297 GGFRSTQDTVIALDALSAYWIASHTTEER------GLNVT---LSSTGRNGFK--SHALQLNNRQ 1350

  Fly  1182 VKLLAK---------------GQGRAQVQLTYRYNVA----------------------TKEARP 1209
            ::.|.:               |..:..:::...|||.                      |.||..
Human  1351 IRGLEEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANE 1415

  Fly  1210 SF-----------------------------------KLTTTVKKSHKGRLILGICGTYTPIAAS 1239
            .:                                   :....|.:..:.|:...:|     |..:
Human  1416 DYEDYEYDELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVC-----IWRN 1475

  Fly  1240 ERNKTTNMALMQVQLPSGY---VCDIEPFADIEAISD--VKRVETKNEDTEVHIYFEKLSPGDRK 1299
            .:...:.||:..|.|.||:   ..|:|   .:.::||  |...||  |...|.:||:.: |..|:
Human  1476 GKVGLSGMAIADVTLLSGFHALRADLE---KLTSLSDRYVSHFET--EGPHVLLYFDSV-PTSRE 1534

  Fly  1300 CLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTS---LCDICHGNEC 1350
            |:..||:....|..::|:...|||||..||..:.||...:.   |..:|....|
Human  1535 CVGFEAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVC 1588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	295/1311 (23%)
		A2M_2	859..1135	CDD:239227	95/337 (28%)
		A2M_recep	1243..1336	CDD:462226	32/97 (33%)
LOC110384692	NP_001338929.1	YfaS	<138..1336	CDD:441940	288/1265 (23%)
		ANATO	686..750	CDD:237984	9/63 (14%)
		A2M	781..869	CDD:459711	32/91 (35%)
		TED_complement	982..1315	CDD:462227	97/352 (28%)
		A2M_recep	1481..1570	CDD:462226	31/94 (33%)
		NTR_complement_C4	1588..1742	CDD:239639	1/1 (100%)