DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tep1 and LOC101730404

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_031761602.1	Gene:	LOC101730404 / 101730404	-ID:	-	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	812	Identity:	201/812 - (24%)
Similarity:	323/812 - (39%)	Gaps:	200/812 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 VKGHVVATIEGSSTEQSLPIDGEVNVEFPISATAKRLLKITAIVTEELTDIKHNG---TAYVTVH 309
            |||::..|.|         ||..   .|.:|:..:..:.:.|.:|||.|..|..|   ..::.:
Frog     5 VKGYLQTTRE---------IDLR---PFNVSSNPRVKIMVLASLTEEKTGHKELGFHFLQFIVL- 56

  Fly   310 QHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSP---------------------VMDSSKMVNF 353
               ..:|.:...|:|:.|:.......|.||...|                     |.|.:.|..|
Frog    57 ---ENVEFVNLDTYYQKGIPFTGMMKVFNLKKDPMRNEKVYLVVNVDEVDTNITLVTDENGMARF 118

  Fly   354 NVLCCQVSK-NFSASLQNSIATEH--------------------IMLPETCQSCLVTSTFDTAEN 397
            ::   ..|. |...||...|:.|.                    .:..:|....|:.||..:. :
Frog   119 SL---DTSDWNDMVSLTGRISFEEGAGYFRALQWLFPFYSESNSFLKVQTVAEDLLCSTKQSV-S 179

  Fly   398 IERYIYKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEK---- 458
            :|   |.::|      |...|:          || :|.:|.: ::::|.|:.:...::..|
Frog   180 VE---YTIDK------NELDPE----------SD-HLSFFYI-LMSKGTIITAKEHKVDVKNLPS 223

  Fly   459 ----KKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEALPRD 517
                :.|..:.|..|..|||.||:.|:.|. ||.:.:|....::...|:|.::: ...|...|..
Frog   224 GPILQGSFNVTFLVTMNLVPVATLLVYAIFPDGEVAADRVRYNVPICFDNKVQLEFRENNVHPGG 288

  Fly   518 EVSLKVKTNPHSFVGLLGVDQSVLL------LRSGNDLNR------DLILNNLATY--------- 561
            .|:|.||.:..|...:..||:.:||      .:.|:|:.|      ...:.:...|
Frog   289 NVNLDVKADAGSLCSVRSVDKGLLLHQEHKTNKMGSDILRFYGRGFPYTIEDFEPYPCLEDVPVP 353

  Fly   562 -------------------------STDLVILTNANINIYRSSGGCYTNPGYTNCTGSLIGRTMF 601
                                     |:.|.:.||..|   |....|.. |.||.       |...
Frog   354 PNRAKRSLKRAPWYQSEADVYSLFKSSSLKVFTNTRI---RKPVTCEL-PEYTR-------RFSI 407

  Fly   602 KNEPTKNSGPVPIVGSTRAQASLP---------PVRKLFPETWLFSNITDVGANGEYIIKETVPD 657
            |:.          ||:...:...|         ||||.||||||: ::..||..|:..:..|.|.
Frog   408 KDG----------VGAADRKLDSPGTAPASKEHPVRKFFPETWLY-DLVSVGPQGKKSLNLTAPH 461

  Fly   658 TLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKA 722
            ::|.||...|.:. .||.....: .:::.|||:||...|||||.:.|...:..:|:|||...|..
Frog   462 SITEWVTDAFCVG-NSGFGEVHD-IKMKTFQPYFIDLLLPYSVVQKEHFTLTALVYNYLNHCVLV 524

  Fly   723 KVLMDNSDGQYEFIE-TTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAIS 786
            :|.:....   ||.| .|:...|..:.|.......|           .|...|:|....|:|:.:
Frog   525 EVALTIPP---EFGEPRTDIEKSACICGQETASFTW-----------NITASKLGTIPFKVTSRA 575

  Fly   787 KYA-GDRLHQIL----KVEADGVQKYV-NKAVLINVQRLNRRSLAPPEKTIIIEKA----DNVIE 841
            .:. ||....:|    |.:.|.|||.: .|...:.|.:.:...|.|...::..|.:    |||:|
Frog   576 LHVEGDCSDVVLDPETKFKHDAVQKTILVKPSGVEVFKTHTSLLCPTGDSVRDEVSLVLPDNVVE 640

  Fly   842 GSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKR 906
            ||......|.|......:.:|.||:.||.|||||||..|.|::..|.||::......||::|...
Frog   641 GSGHAHITVLGDVLGNTISNLGDLLQLPYGCGEQNMAQFAPNVYVLEYLQSAKALTPEIKDKVLN 705

  Fly   907 YVETGYQIELNYKRNDGSFSAWGQHDALGSTW 938
            |:.||||.:|.:|.::|::||:|:.|..|:||
Frog   706 YLTTGYQRQLMFKHDNGAYSAFGKKDEEGNTW 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081
		A2M_N_2	411..542	CDD:285005	33/140 (24%)
		A2M	634..726	CDD:278630	31/91 (34%)
		A2M_2	859..1135	CDD:239227	35/80 (44%)
		A2M_comp	910..1135	CDD:284982	14/29 (48%)
		A2M_recep	1245..1335	CDD:284981
LOC101730404	XP_031761602.1	MG4	61..>134	CDD:407661	15/75 (20%)
		A2M_N_2	161..313	CDD:400170	40/173 (23%)
		A2M	439..528	CDD:395153	31/91 (34%)
		SVA	<490..571	CDD:398804	26/94 (28%)
		ISOPREN_C2_like	657..>737	CDD:415487	33/79 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010