Protein Alignment Tep1 and cpamd8

DIOPT Version :9

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_002934416.1
• Gene: cpamd8 / 100491045
• XenbaseID: XB-GENE-985023
• Length: 1827
• Species: Xenopus tropicalis
• Alignment Length: 1755
• Identity: 438/1755 - (24%)
• Similarity: 699/1755 - (39%)
• Gaps: 495/1755 - (28%)

  Fly     1 MLWLILSSTILHCVLLSNANGL--YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLT--GPSL 61
            ::|:|.|        .|.|...  |.|.||...||.....|.|.|.|.|..|:|.:.|.  |.::
 Frog     6 IVWIICS--------FSRAEDRQGYLVAAPSVFRSGVEEVVSVTIFNATTETKVQLQLVVKGETV 62

  Fly    62 NSRKYVDVQSMSSKSVRFDIPKLTEGDYELKVMGS-----GGIEFQNSTKLSFAPDLNWLYIQSD 121
            .....:   .:...:|:..:|....|...|||.|:     .|..|.|||.::.....:.::||:|
 Frog    63 AHGHGI---VLDKGTVKILVPSGLRGQANLKVWGNRHLTEEGFSFHNSTTVTVDSKGSSVFIQTD 124

  Fly   122 KATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKP-AKGVYSGELQLSDR 185
            |..|||..|:...:..:..:.||.  .:.|:..|.|...:.|..|.|::| ..||.:....|||:
 Frog   125 KPIYKPKQKVLINMFMVTPDLRPT--SEKIEAYILDPRGSRIIQWTDLRPICCGVVNMSFPLSDQ 187

  Fly   186 PVLGNWTVTATVQDEGKVTN-VLVVDKYVVPKFEVVVLTAKNVAASAGYIR-------ATIKARY 242
            ||.|.|.:.|..|  |...| ...|.|||:||||:|:       :...|||       .|:||||
 Frog   188 PVFGEWLIFAETQ--GHTYNKSFSVQKYVLPKFELVI-------SPPSYIRDIGTCEKGTVKARY 243

  Fly   243 TFKKPVKG--------------------HVVATIE--GSS-----TEQSLPID------GEVNV- 273
            ||.|||||                    .|:.|:|  ||:     .:..:|:|      |.||:
 Frog   244 TFGKPVKGLLTINMTVTGVGYYKHEIGLQVLKTMEIYGSAVFDICAKDMMPVDFPEHFRGTVNIW 308

  Fly   274 --EFPISATAKRLLKITAIVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVV 336
              ...:..:.:.....:..|.::|.|||:....                ...::||:..:.|..|
 Frog   309 ATVISVDGSKQVTFDDSTPVQKQLIDIKYTKDT----------------KKQFKPGLPYQGKVEV 357

  Fly   337 RNLDGSPVMDSSKMVNF------NVLCCQ-VSKNFSASLQ-NSIAT--EHIMLPET--------- 382
            ...||||....:..:..      ||...: ||:|.....| .||.|  :::.| ||
 Frog   358 TYPDGSPADGVTVQIKAELTPKDNVYTSELVSRNGLVEFQIPSIPTGAQYVWL-ETKVMAIDGKP 421

  Fly   383 -----CQSCLVTSTFDTAENIERYIYKLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVV 442
                 ..:.|..|::.:.......|....:||::.     .:.|..||.....::.|.|   .:|
 Frog   422 AGEQYLPNYLSISSWYSPSKCHLLIQPPEEPLLVG-----EEARIALKSTCPCNSTLHY---ELV 478

  Fly   443 ARGNIVLSLFQ----EMKEKKKSQEIEFEP------------------------------TFALV 473
            ||||||||..|    .:|..|:...:.|:.                              |..:.
 Frog   479 ARGNIVLSGKQPGKVTLKRSKRDAFVTFDKDTHESVTNTASTQIPSEDSTVWLTYVHFTVTHNMA 543

  Fly   474 PQATIFVHYIID-GVLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLKVKTNPHSFVGLLGV 536
            |.:.|.|:|:.: |..::|...:.|:..|||.:.: |:||.:.|.|.|.:.||....|.|.:..|
 Frog   544 PLSRILVYYVRENGEGVTDSAQIPIKPVFENQVSLTLSTNNSRPGDAVDINVKAAKGSCVCVATV 608

  Fly   537 DQSVLLLRSGNDLNRDLILNNLATY---------------------------------------- 561
            |:||.|||:|..|..:.|...|:.:
 Frog   609 DKSVYLLRNGFQLTPEQIFQELSEFDVSDGTGKDEGHFWWPGMGSQRRRRSSLFPWHWDITKDAR 673

  Fly   562 ----STDLVILTN-ANINIYRSSGGCYTN---PGYTNCTGSLIG----RTMFKNEPTKNSGPVPI 614
                .|.|:::|: .::| :|.|||.||:   |.:...||:|:|    |...:.|..|
 Frog   674 FAFTETGLIVMTDIVSLN-HRQSGGMYTDEAVPAFQPHTGTLVGSSYTRMATRTEKRK------- 730

  Fly   615 VGSTRAQASLPPVRKLFPETWLFS--NITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAV 677
                         |..|||||::.  |::||  .||..:...|||::|:|:....::|.:.||.|
 Frog   731 -------------RTFFPETWVWHCFNVSDV--TGEQQLHVEVPDSITTWITEAIAISSKKGLGV 780

  Fly   678 TRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYL--GMDVKAKVLMDNSDGQYEFIETTN 740
            . ..:.::.|:||||...|||.|.|||.:.||:.|:|||  |::|..|:.:...   .:|:....
 Frog   781 A-GQAHLKAFKPFFIDFTLPYHVIRGEQVKIPLTVYNYLPVGVEVHVKITIPKG---IKFVGYPG 841

  Fly   741 KNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAG--------------- 790
            |   |||  :|:   |.:.:...:..|.:.....:|...:...|:: :||
 Frog   842 K---QYL--IRK---LCVASGETKPTSAVFAFTDLGQANISARALA-FAGMSCFPEGNTLRNKHA 897

  Fly   791 -------------DRLHQILKVEADGVQK-------------------------YVNK------- 810
                         |.:.:.|.||.:|:.:                         ||.|
 Frog   898 DDAYLEKKVPAGTDFVRRSLMVEPEGLAREYTYSVFFCPNEKIQISTPNKFEYQYVQKPQRMTHF 962

  Fly   811 -------------------------AVLINVQRLNRRSLAPPEK--------------------- 829
                                     .::|..|: |.|:.....|
 Frog   963 DLTVKAHNDAHIALSSGPHDMAEMIEIVIGGQQ-NSRTWISTSKMGDPVSSASTSSVLSWDEFRA 1026

  Fly   830 ---------------------TIII------------------------------EKAD------ 837
                                 ::|:                              |:.|
 Frog  1027 FWISWKNGVIQVGYGIYSSNDSVIVEWTVDRQPDVKFIGFSTGWGSMGEFKIWRKEETDENHNEA 1091

  Fly   838 -------NVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNR 895
                   |||.|||.....:.|....|.:.:||:|:.||.|||||||.:|.|::..|.||:...:
 Frog  1092 FTLGVPHNVIPGSERATASIIGDVMGPTVSNLDNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTRQ 1156

  Fly   896 QDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNV 960
            ...|:|::|..|:..|||.:|.|||.|||:||:|:.|:.||.||||:|::||.|:..:|.||...
 Frog  1157 LCPEVESEAVDYLVQGYQRQLTYKRLDGSYSAFGERDSSGSMWLTAFVLKSFAQSRGFIFIDPGE 1221

  Fly   961 LVAGLDFLVSRQSTDGKFKELGMVIH-----NSHGSPLALTSFVLLTFFENEEYMPKYKHVIDRA 1020
            |.|..|:::..|:.||.|..:|.:::     .:||. :|||::|.....|........:..:.:|
 Frog  1222 LSAAKDWIIQHQNKDGSFPAMGRILNKDIQGGNHGK-IALTAYVAAALLETGVTSEDERIAVSKA 1285

  Fly  1021 VEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWW--TGSDKCK---- 1079
            ..|:.:.:...::||..|:.:.||:|.|:..|...|.||:.:|........|  |||...:
 Frog  1286 KLFLESHLFTVDDPYTTALTSYALTLLRSTYAPVALRKLNAMAITHDGFTHWSLTGSAATEEDTF 1350

  Fly  1080 ------------SSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMAL 1132
                        |:|||.|:|.||............|:|.||..:|||.|||.|:|||.|.:.||
 Frog  1351 MGFNDGLSQSVISAEVEMTAYALLTYTLMGDVASALPVVKWLSQQRNSLGGFSSTQDTCVALQAL 1415

  Fly  1133 TKYELQSHASTEAIDIEFWHLNED-KKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQL 1196
            .:|.:.|:.....:.|.....|.| ::...:.:.|:..:||.::|.....:.:.|||:|...:|:
 Frog  1416 AEYAILSYVGGVNLTISLASTNLDYQETFELHRLNKKILQTAKIPSIPTGLFVSAKGEGCCLMQI 1480

  Fly  1197 TYRYNVATKEARPSFKLTTTVKK-----------------------------SHKG----RLILG 1228
            ...|||....|:|:|:|...:|:                             ||:.    ::.|.
 Frog  1481 DVHYNVPDPVAKPAFQLLIYLKEPKLSRKRRHVVHQETPLRDRALPDDDDPGSHQDHQEYKITLE 1545

  Fly  1229 ICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDV--KRVETKNEDTEVHIYFE 1291
            .|..:....||      |||::::.|.||:..|||....:.....:  ||.|.  :..:|..||:
 Frog  1546 ACTRWLHAGAS------NMAVLELALLSGFRADIESLEQLLLNKQIGLKRYEI--DGRKVLFYFD 1602

  Fly  1292 KLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTS---LCDICHGNECGNM 1353
            ::......|:.|:|...:.|....|..|::||||.....||.||:...|   ..::|.|..|..:
 Frog  1603 EIPSQCLTCVKLQAFREYIVGKTAPVPVKIYDYYEPTFEATRFYNASESSPLSRELCDGTTCNEV 1667

  Fly  1354  1353
             Frog  1668  1667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	28/85 (33%)
		A2M_N_2	411..542	CDD:285005	43/166 (26%)
		A2M	634..726	CDD:278630	37/95 (39%)
		A2M_2	859..1135	CDD:239227	106/298 (36%)
		A2M_comp	910..1135	CDD:284982	85/247 (34%)
		A2M_recep	1245..1335	CDD:284981	27/91 (30%)
cpamd8	XP_002934416.1	MG1	22..>83	CDD:375333	17/63 (27%)
		YfaS	<54..>257	CDD:225248	68/216 (31%)
		MG4	339..>398	CDD:375332	13/74 (18%)
		A2M_N_2	444..615	CDD:377903	46/178 (26%)
		A2M	737..828	CDD:365945	36/93 (39%)
		Methyltransf_FA	974..1075	CDD:371989	6/101 (6%)
		A2M_2	1119..1418	CDD:239227	106/299 (35%)
		A2M_recep	1556..1646	CDD:369460	28/97 (29%)
		KAZAL	1700..1744	CDD:197624

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920