Protein Alignment Tep1 and LOC100489060

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_002938549.2
• Gene: LOC100489060 / 100489060
• XenbaseID: XB-GENE-29079547
• Length: 1482
• Species: Xenopus tropicalis
• Alignment Length: 1550
• Identity: 409/1550 - (26%)
• Similarity: 664/1550 - (42%)
• Gaps: 283/1550 - (18%)

  Fly     2 LWLILSSTILHCVLLSNANG--------LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTG 58
            :|   |..:..|:||:...|        .|.:|.|..|...|.....:.:.:...|..::::|..
 Frog     1 MW---SCALTLCLLLTAFPGGDPAPPDPQYLLLVPTVLHGASEEKFCLLLSHLNETVTMTLTLYL 62

  Fly    59 PSLNS---RKYVDVQSMSSKSVRFDIPKLTEGDYELKVMGSGG--IEFQNSTKLSFAPDLNWLYI 118
            |:.|.   .|.| .:......|.|..|||......:..:...|  :.|::..|:...|..|.::|
 Frog    63 PTQNHTLLEKQV-TEKEEDGCVTFMTPKLEVAAVAILTLDVQGDALHFKSQRKILIKPLQNPVFI 126

  Fly   119 QSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLS 183
            |:||..||||.|:|||:..||:|..| |.:|...:.|.|...|.|..|.:::..||:.....|||
 Frog   127 QTDKPIYKPGQKVQFRIASLDENFHP-VSEKFPAVYITDPQGNRISQWLNVELKKGLTQESFQLS 190

  Fly   184 DRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPV 248
            ..|.||.:.:|...:....||:...|::||:||:||.|.....|......|:.|:..|||:.|||
 Frog   191 SEPTLGIYKLTVGREKSAPVTHSFSVEEYVLPKYEVQVKLPPVVGIMDKGIKVTVCGRYTYGKPV 255

  Fly   249 KGHV-VATIEGSSTEQSL---PIDG---EVNVE---------------FPISATA-KRLLKITAI 290
            .|.: |......|...:|   ..||   |:|..               |.:..:. :..::.:|.
 Frog   256 LGRIKVRVCRKFSDRYNLCKGEEDGVCEEINHRAGPNGCFSEVVSTRMFQMRRSGYEDKIRASAT 320

  Fly   291 VTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMV---- 351
            :.|:.|.::........:.:...|:......:|||.|:....:..:.:..|:|:.:.:.::
 Frog   321 IIEDGTGVELTAAVSSEIKKTLAKVSFRHLDSHYRKGLPLFGQLFLEDASGNPMANETVVIFVGY 385

  Fly   352 --NFNVLCCQ---------VSKNFSASLQNSIATEHIMLPETC-QSCLVTSTFDTAENIERYIYK 404
              ||.....|         .|....:|||.....:.   .|:| |...|:.::...|...:..|.
 Frog   386 GTNFTYTTGQDGTAEFLIDTSNVQKSSLQIRARYKE---GESCYQYRWVSVSYQGDERSVKEFYS 447

  Fly   405 LNKPLMIAINTKKPQLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKS------QE 463
            ..|..:     |...:.|:|:.. ..:..:.:|||:....|....::|..:...|..      .|
 Frog   448 RAKSYL-----KIQPIYKILECQ-KQEKVIVHFILSAEGVGETTNAVFHYLVMSKGGIAGHGRHE 506

  Fly   464 IEFEP------TF--------ALVPQATIFVHYIID-GVLMSDEKTVDIERDFENTIEI-LTTNE 512
            ||..|      ||        .:.|.|...|:.|:: |.:::|..::.:|:.|.|.:|: .:.:|
 Frog   507 IEISPNQNASGTFWFRLTAGTDIAPSANFLVYLILESGEVIADSISLKVEKCFGNKVELSFSPSE 571

  Fly   513 ALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILN-----NLATYSTD-------- 564
            |||.....|.:.|.|.|...|..||:|||:|:...:|:...|.|     :|:.|..|
 Frog   572 ALPGAPADLHLLTAPSSLCALRAVDESVLILKPEAELSAQTIYNLLPLQDLSGYIHDGNFLEELW 636

  Fly   565 ---LVILTNANINIYRSSGGCY---TNPGYTNCTGSL---IGRTMFKN---EPTKNSGP------ 611
               .:.:....||      |.|   |||.:...|.::   :|..:|.|   .|....||
 Frog   637 DDPCIKMEPLFIN------GIYYMPTNPEWDTDTYTILKNLGLKVFTNARIRPPLVCGPRSFYEH 695

  Fly   612 --------VPIVGSTR--------------------------AQASLPPVRKLFPETWLFSNITD 642
                    ||:..|..                          |:..:..|||.||||||: .:.:
 Frog   696 YGTGGPFAVPMSLSAGMGVQAGMGVQAGMSGAGLHIGRNIPVAEPVIETVRKYFPETWLW-QLVE 759

  Fly   643 VGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIA 707
            ..|:|:..:..|||||:|:|....|..|..:|..::...|.: .|||||:...||||..|||:..
 Frog   760 TDADGKADLAVTVPDTITTWKAGMFCTSQGAGFGLSETISLV-AFQPFFLELTLPYSAIRGEIFT 823

  Fly   708 IPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRP 772
            :...|||||...::..:|:::|:   :|:....|         .::....:.||....:|:.:..
 Frog   824 LKATVFNYLSQTIRVGILLEDSN---QFLAKPTK---------VQEDGYCVTANGQVTLSWEVTL 876

  Fly   773 KKVGLTTLKITA-------------ISKYAG--DRLHQILKVEADGVQKYVNKAVLI-------- 814
            |.:|.....::|             :|...|  |.:.:.:.||.:||:|....:.:|
 Frog   877 KSLGEVNFTMSAETLNGEGLCENEIVSPAQGRKDTITKHIIVEPEGVKKEETHSTMICGKGSEIT 941

  Fly   815 -NVQRLNRRSLAPPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMF 878
             |:      .|..|||         |:|||....|...|......:::|.:||.:|.|||||||.
 Frog   942 ENI------PLKLPEK---------VVEGSARAYFSAVGDILGTAMQNLGNLVQMPYGCGEQNMV 991

  Fly   879 NFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYV 943
            .|.|.|....||...|:...|:::|...|:.||||.:|:||..|||:||:||....|:|||||:.
 Frog   992 LFTPIIYISEYLNKTNQLTPEMKSKTLSYMSTGYQKQLSYKHPDGSYSAFGQRYGEGNTWLTAFT 1056

  Fly   944 IRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLLTFF 1004
            ::||.:|..:|.|::.::...|.:|..||..:|.|..:|.:.:|:.    ...:.|.:::.:...
 Frog  1057 MKSFARARAHIYIEEKLITGALLWLSIRQKPNGCFHSVGKLFNNAMKGGVDDEVTLAAYITIALL 1121

  Fly  1005 ENEEYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYK-VLDKLDKLATR--- 1065
            |..  :|.....:..|:..:.:.:...|..|..|:.|.|.:||...:..: :|..||:.|.:
 Frog  1122 EYP--LPVTHPTVRNALFCLESALGGKNGIYTKALMAYAFTLAGRMDIRRQLLQSLDEQAIKKDG 1184

  Fly  1066 -----RGDHKWWTGSD-----KCKSSEVETTSYVLLALL-EHNISDE----PKPIVDWLISKRNS 1115
                 |.:....:|.|     :..|:|||..||:||||| :||:|||    ...:|.|:|.::|.
 Frog  1185 TVHLHRPEFSDDSGVDRFPYRRAPSAEVEMNSYMLLALLSKHNVSDEDLTLATQVVSWMIKQQNP 1249

  Fly  1116 NGGFVSSQDTVVGIMALTKYE--LQSHASTEAIDIEFWHLNEDKKHV---RVTKENEFKVQTHQL 1175
            ||||.|:|||||.:.||:.|.  ..||.:...:.     |:.||..|   .|...|...:|...|
 Frog  1250 NGGFSSTQDTVVALQALSLYGSLTLSHDAMRTVS-----LSLDKTPVAEFHVEDSNRLLLQRIAL 1309

  Fly  1176 PENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTV------KKSHKGRLILGICGTYT 1234
            .|...:......|.|...:|.|.||||...:....|.::.|.      :||.|         |:|
 Frog  1310 KEVPGDYLATVSGSGCLYLQTTLRYNVPIPKEDAPFTISVTTDPETCDRKSLK---------TFT 1365

  Fly  1235 PIAASE---RNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKN--------EDTEVHI 1288
            .:|...   :...:|||:::|:|||||: .|:|        .||::...|        ...||.:
 Frog  1366 IVANVSYVGKRLNSNMAVVEVKLPSGYI-PIKP--------SVKKMTASNRLIQRAEAHANEVIV 1421

  Fly  1289 YFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTSLCD 1343
            |||.|.. |.:...........:.||:|:.|.:||||.|:..|...|....|..|
 Frog  1422 YFESLFK-DIQSFRFSVEQEIPIGNLQPATVVVYDYYETDDLAITKYDAPCSAKD 1475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	336/1260 (27%)
		A2M_2	859..1135	CDD:239227	103/298 (35%)
		A2M_recep	1243..1336	CDD:462226	31/100 (31%)
LOC100489060	XP_002938549.2	YfaS	57..1391	CDD:441940	369/1395 (26%)
		A2M_2	971..1269	CDD:239227	103/299 (34%)
		A2M_recep	1378..1468	CDD:462226	31/99 (31%)