DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and ovos2

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_002941671.3	Gene:	ovos2 / 100487907	XenbaseID:	XB-GENE-6461109	Length:	1443	Species:	Xenopus tropicalis

Alignment Length:	1516	Identity:	350/1516 - (23%)
Similarity:	593/1516 - (39%)	Gaps:	304/1516 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVD-VQSMS-SKSVRFDIPKLT 85
            |::..|..|:|.......|.:....::..:||:|....:|...:.: ||..| .:...|.:|.:|
Frog    25 YALTIPALLKSGETQRACVTLLGYEQSVALSVTLEHQRVNITIFAEKVQPPSYFRCNEFMVPTVT 89

  Fly    86 EGDYELKVMG-SGGIEFQNSTK-LSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVID 148
            :...:...:. |||.|.....| :..||......||:||..||||.|::||::.|:....| |.:
Frog    90 KTAPDFVTLSVSGGDEAVKDRKAVVIAPTETIFLIQTDKPVYKPGQKVRFRLISLNTMLLP-VSN 153

  Fly   149 KPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNVLVVDKYV 213
            |...:.:.|...:.|..|::.:...||...|..|......|.:.:||.......|.....||:|:
Frog   154 KYPAVYLEDPLGSRIAQWQNQESVGGVVQLEFSLISDAAPGFYIITAERASGQPVREGFTVDEYI 218

  Fly   214 VPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVV------ATI---------------- 256
            :|:|.|.......::.....:.....|.||:.:||.|.|.      ||.
Frog   219 LPRFSVTADPPSIISILDNVLILNASAIYTYGQPVPGFVTMKCCREATFYYGRKGNCFKGNRDVC 283

  Fly   257 ---------EG---------------SSTEQSLPID---------GEVNVEFPISATAKRLLKIT 288
                     :|               |..:.||.:|         .:|..:|.|..|::  |...
Frog   284 TNVIKDLDPDGAFYGVIDLLPFQLGQSGFQMSLEVDLTVEEDGTGVQVTQQFSIMITSQ--LATL 346

  Fly   289 AIVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHY-RPGVSSEFK---------TVVRNLDGSP 343
            ...|:.:......|..|         |..:.....| .|..:.|.:         |.:.:.:|..
Frog   347 VFDTDTMNGFYKRGIPY---------LAKMILTDEYGNPMANEEVEVELGGETLGTALTDAEGKA 402

  Fly   344 --VMDSSKMV--NFNVLC-------CQ-------------------------------VSKNFSA 366
              .:|:|..|  ||.|:.       |.                               :|:..|.
Frog   403 EYAIDTSGFVQENFTVVANYKNPTQCYYTEWEGPDYPTAQYFVLRFYSETGSFLEIQGLSEELSC 467

  Fly   367 SLQNSIATEHIMLPETCQSCLVTSTFDTAENIERYIYKLNKPLMIAINTKKPQLRK------LLK 425
            ...::::..:.:.|:.......|:||        |...:::..::....:...|.:      ::.
Frog   468 GQVHNVSVRYTLSPDGVGEQATTATF--------YYLVMSRAKIVEHGQQDVTLSQSKSGLFIIG 524

  Fly   426 INIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDGVLMS 490
            :|:.||                                        |.|.|.:..:.|:...|::
Frog   525 LNVSSD----------------------------------------LAPGAQLIAYSILSLELIA 549

  Fly   491 DEKTVDIERDFENTIEILTTNEAL--PRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDL 553
            |..::.||:.|.|.:. |:.:|.|  |...:||.:...|.|..|:..:|.|:||:.....|:...
Frog   550 DTVSLYIEKCFPNQVS-LSFSEDLGPPASNISLNLSAAPGSLCGVKVIDSSLLLINPYESLSASG 613

  Fly   554 ILNNLATYS--------------------TDLVILTNANINIYRSS---GGCYTN---PGYTNCT 592
            :..:|...|                    .:.|:.......:..||   |..|.|   .|....|
Frog   614 VYYSLPYLSLFGYNYGGFNVEGPEPPCEDPNTVVFCKGRYYVPVSSSTEGDTYQNLRRVGLVLGT 678

  Fly   593 GSLIGRTMFKNEPTKNS-------GPVPIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYI 650
            .|.|.:.:.....||.|       ..||..|::.:..::..:|:.|.||:::..:: |.:.|:..
Frog   679 SSRIRKPVVCGMETKLSVTRKSVMDSVPAFGTSASNGNVNTLRQNFSETFMWQMVS-VDSYGQST 742

  Fly   651 IKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNY 715
            |..|||||:|.|..:.|.:|...|..:|:..:....|.|||:..:||||:.|.|::.:...|.||
Frog   743 ITGTVPDTITKWQGSMFCVSENEGFGMTKYSANFTSFLPFFVELSLPYSLTREEILMMNAFVSNY 807

  Fly   716 LGMDVKAKV-LMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRG-ISFMIRPKKVGLT 778
            |...||..| |..::|     .:...:||.|       .|.:   .:..|| .|:.|....:|..
Frog   808 LKECVKVNVTLKPSAD-----FQAVPQNVVQ-------DKCI---CSGSRGSYSWNIIALSLGEI 857

  Fly   779 TLKITAISKYAG---------------DRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPE 828
            :..::|.:.:.|               |.:.|.:.||.:|::|....:.|:.|:..|.      |
Frog   858 SFTVSAETTHIGASCDGPFDPSQPTRKDTVIQTILVEPEGIRKEDTSSNLVCVEDSNF------E 916

  Fly   829 KTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAK 893
            ..|.|....|:::||......:.|......|.:|.:|:.:|.||||||:....|....|.||...
Frog   917 LPINITLPKNMVQGSAAAFVTLVGDVLGLPLSNLQNLLQMPYGCGEQNLARMAPIPYVLEYLNGT 981

  Fly   894 NRQDQEIENKAKRYVETGYQIELNYKRNDGSFSA-WGQHDALGSTWLTAYVIRSFHQAAKYIDID 957
            |:....:...|.:|:..||..:|.||...|::.| ||. .:.||:||:||..::|.:|.|||.||
Frog   982 NQLTDVLLQIAIQYLNEGYYRQLRYKLPSGAYDAFWGS-TSHGSSWLSAYTFKTFEKAKKYIYID 1045

  Fly   958 KNVLVAGLDFL-VSRQSTDGKFKELGMVIHNSHGS--PLALTSFVLLTFFENEEYMPKYKHVID- 1018
            :.:....|..| .|::..:|.||..|.:.....|.  .|..|:::.:...|: .|......:.|
Frog  1046 EKIQQQTLISLQTSQKLENGCFKLQGNLFMGQCGQERDLCFTAYLAIALLES-NYSSGMTLLDDA 1109

  Fly  1019 -RAVEFVVTEVHQSNEPYDLAIAALALSLARN---RNAYKVLDKLD-KLATRRGDHKWWTGS--- 1075
             |.:|..:  |:.|..|:. |.:....:||:|   ||  .:|::|. |..:.||...|....
Frog  1110 LRCLEAAI--VNASTLPFK-AYSLYVFTLAKNWEIRN--PLLNELKAKAISERGTLHWERDGRPG 1169

  Fly  1076 --------DKCKSSEVETTSYVLLAL-----LEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVV 1127
                    .....:|||.|:|:||::     |.|:.......|..|||.::||.|||.|:||||:
Frog  1170 PEGVPLFYPNNAPAEVEITAYMLLSIAKGPSLTHDDLTYMAEISVWLIQQQNSYGGFRSTQDTVM 1234

  Fly  1128 GIMALTKY-----ELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAK 1187
            .:.||..|     :..:|.:. .:..||    .|...:.:.:.|...|||..||:.:....:...
Frog  1235 ALQALAFYAQLIFKPNAHHNV-VLRNEF----GDVGQLTLRENNRLVVQTQALPKASGNYSISVN 1294

  Fly  1188 GQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTYT---PIAASERNKTTNMAL 1249
            |.|...||.|.|||:...:...:|.:   |..|.....:.|:..|.|   .::.......|||.:
Frog  1295 GTGCCLVQSTIRYNIPVPKENSAFYV---VADSASENCLNGVAYTITITLSVSYQGLRNETNMVI 1356

  Fly  1250 MQVQLPSGYVCDIEPFADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANL 1314
            :.:::.|||..|......:|....|.|.|.:|  ..:.:|...: |.....|:.:.:....|.|:
Frog  1357 IDIKMLSGYQADYFSLRQLENSKQVSRTEEQN--NHIFLYLSSV-PQKPIQLSFKMLLGSRVLNV 1418

  Fly  1315 KPSWVRLYDYYATERSATEFY 1335
            |...|.:||||.|..:....|
Frog  1419 KSGSVYVYDYYETGENGFASY 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	25/84 (30%)
		A2M_N_2	411..542	CDD:285005	25/138 (18%)
		A2M	634..726	CDD:278630	32/92 (35%)
		A2M_2	859..1135	CDD:239227	94/301 (31%)
		A2M_comp	910..1135	CDD:284982	77/250 (31%)
		A2M_recep	1245..1335	CDD:284981	24/89 (27%)
ovos2	XP_002941671.3	A2M_N	124..214	CDD:396416	26/90 (29%)
		MG3	216..>285	CDD:407663	13/68 (19%)
		MG4	349..442	CDD:407661	16/101 (16%)
		A2M_N_2	456..603	CDD:400170	33/195 (17%)
		A2M	727..818	CDD:395153	32/91 (35%)
		A2M_2	947..1242	CDD:239227	94/301 (31%)
		A2M_recep	1352..1439	CDD:400149	24/89 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8886
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9328
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920