Protein Alignment Tep1 and cd109

DIOPT Version :9

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_031758448.1
• Gene: cd109 / 100486953
• XenbaseID: XB-GENE-954886
• Length: 1433
• Species: Xenopus tropicalis
• Alignment Length: 1416
• Identity: 374/1416 - (26%)
• Similarity: 644/1416 - (45%)
• Gaps: 241/1416 - (17%)

  Fly    81 IPKL----TEGDYELKVMG--SGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLD 139
            :|:|    ..|.|||.|.|  ...:.|.|.|.|.|......::|:::...||||.:::.|:|...
 Frog    87 LPQLPLNSVNGKYELNVKGYSEENLIFFNKTSLEFKSKGFSVFIETNSVFYKPGQEVKIRILAFS 151

  Fly   140 KNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVT 204
            .:.:|  ....:.|.|.|...|||:.|.:.:...||.|..|.|||.|.||:||:...:..:....
 Frog   152 FHMKP--YKSTVDIYILDPQGNLIEQWLEEEMELGVVSQSLYLSDNPPLGDWTIKVKLHQQLHYQ 214

  Fly   205 NVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATIEGSSTEQSLPIDG 269
            ...|::: |:|:|||::.|....:....::..|:.|:||:..||||.:...:..:|..:.
 Frog   215 TFTVMEQ-VLPRFEVLLNTTLYHSIKNPHLEGTVTAKYTYGMPVKGKLSVMLSHNSIYKK----- 273

  Fly   270 EVNV--EFPISATA---------KRLLK--------------ITAIVTEELTDIKHNGTAYVTVH 309
            :.|:  :|.|:..|         |.|:|              |...|.|.||.|..|.|..|.|.
 Frog   274 KTNITKDFVINGCARFSFSNVELKELMKNADYGSNKVTGPVDIDVNVKESLTGITQNVTTSVFVI 338

  Fly   310 QHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVLCCQVSK-NFSASLQNSI- 372
            ...:.:|.|..||..:|.::...:..:...||..:....:.....|...|..: ||.   .||:
 Frog   339 DKEYNIEFLDHPTVLKPMLNFTIRLQIVRYDGRKLTAEERDNEVAVTVTQTRRFNFR---DNSVE 400

  Fly   373 --ATEHIMLPETCQSCLVTSTFDTAENIE-----RYIYKLNKPLMIAINTKKPQLRKLLKINI-- 428
              |||:                ::.:|:|     ||....|..:.|.|    |.|..::.:.|
 Frog   401 LNATEN----------------ESEDNVEMIQLTRYTVPKNGIICIEI----PLLADIMHLYIKA 445

  Fly   429 -----------------ISDTY-------------LPYFI------------LTVVARGNIVLSL 451
                             ::.||             :||.:            ..||::|.||..
 Frog   446 EFLDAKNNLFINDLFSSLNGTYIQIKKADQDLKVGIPYTLSVDGSFPLKDISYLVVSKGQIVAG- 509

  Fly   452 FQEMKEKKKSQEIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIERDFENTIEI-LTTNEAL 514
                 .|...:.|...|.....|:..:.|:::. ||.:.:|...|.::..|||.:.| ..|.:|.
 Frog   510 -----GKGNPKNITLNPENTWTPEVCLIVYHVANDGTVTNDVTAVSVQPIFENKVYISWNTTQAR 569

  Fly   515 PRDEVSLKVK-TNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYST--------------- 563
            |.|.|||.|. ..|:|.|.|..:|:.|.||....:::...:|..|.:|||
 Frog   570 PADMVSLNVNVAEPNSLVVLSVIDKRVKLLGDRQEISTANVLKELKSYSTSHIQHYTNPSEVFEM 634

  Fly   564 -DLVILTNANINIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTKNSG-PVPIVGSTRAQASLPP 626
             ::.::|:|||.::....                  .:|:      || .:|:.|:.......|.
 Frog   635 CNIGVMTDANIEVHDHFD------------------ILFE------SGFDIPVQGALPVNFGSPR 675

  Fly   627 VRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFF 691
            :|.||||||::.:: ..|:.....:...|||.:|:|:.:.:.:|...|..:...|.::..|||||
 Frog   676 IRSLFPETWIWKHL-KTGSTTHMTLDLKVPDVITTWITSAYVISENFGFGMLAPPEQLEAFQPFF 739

  Fly   692 ITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDG---QYEFIETTNKNVSQYLRGVRRK 753
            ::.|||..|.|||...:.|||||||..:.:..|.::.||.   |..|:   |.:.||
 Frog   740 LSLNLPSYVIRGEQFVLEVIVFNYLQKETEVSVTLEKSDAFEIQLAFV---NASESQ-------- 793

  Fly   754 KTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQKYVNKAVLINVQR 818
            :::.:|:..|:.:.|.|:|..:|...:.:.|||..|.|.:.|.|:|:|:|||:..::.:|:::..
 Frog   794 QSVSVPSQEGKIVFFPIKPIHLGEIPITVKAISALASDAVTQKLQVKAEGVQQSHSQTLLLDLMG 858

  Fly   819 LNRRSLAPPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPS 883
            ...:|::   :|:......:|:.|||.....|.|......:..:..|:.:|.|||||||..|.|:
 Frog   859 NKPKSIS---QTLNFTFPPDVVSGSEKAFITVVGDHLGLSIRSIKSLIQMPYGCGEQNMIRFAPN 920

  Fly   884 ILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFH 948
            |..:.||....:.::::.:|...:::.|||.:|.|:|.||||||:|..|..|||||:|:|::.|.
 Frog   921 IFIMEYLSRTKQLNEDVAHKLISFIKNGYQRQLVYQREDGSFSAFGNKDPFGSTWLSAFVLQCFL 985

  Fly   949 QAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHN----SHGSPLALTSFVLLTFFENEEY 1009
            :|..:|.:|..||...|.:|:..|..:|:|.|.|.||::    .|.|.:.||::::....|
 Frog   986 KARPFILVDPVVLHNTLTWLLKHQRKNGEFWEPGTVIYSQIQGGHHSAITLTAYIMAALIE---- 1046

  Fly  1010 MPKYKH--VIDRAVEFVVTEVHQ-SNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKW 1071
            .|..|:  .:..|.:::.:::.: .::.|.|::...||||.....|.:.||.|:..|.:.|..::
 Frog  1047 YPGLKNSSQVAAATDYLESQMDEIISDNYTLSLVTYALSLVGRSKATEGLDLLNMRAEQEGQLRF 1111

  Fly  1072 WTGS-DKCK---SSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMAL 1132
            |..| ..|:   |:::..::|.||:.:..|...|...::.||..:|:..|||.|:|||::.:.|:
 Frog  1112 WRSSISSCQHPCSTDIVISAYALLSYVVQNRIAEGMAVMKWLSQQRSHLGGFSSTQDTIIALQAM 1176

  Fly  1133 TKYELQSHASTEAIDIEFWHLNEDKKHV------RVTKENEFKVQTHQLP-ENTNEVKLLAKGQG 1190
            :     |.||...|:.:...:..|...:      ::...|...:||.||. :....:.:.|:|.|
 Frog  1177 S-----SFASVYTINKQILAITVDSHPLNSTATFQIDSNNRILLQTKQLAVQQQMNLTVHAEGTG 1236

  Fly  1191 RAQVQLTYRYNVATK--------EARPSFKLTTTV--KKSHKGRLILGICGTYTPIAASERNKTT 1245
            .|.:|....||:...        .::.:|.|..||  .|.:...:.|.||....|...|.:   |
 Frog  1237 FAILQFHTIYNLKNSVPGRYKSISSQDAFDLGITVLDNKDNLNVVSLNICTRSIPRDGSTQ---T 1298

  Fly  1246 NMALMQVQLPSGYVCDIEPFADIEAIS---DVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIY 1307
            .|.||||.|.||:  .:.|    |.|.   .:|:|: .||. :::||.:.|:..: .|:.:.|..
 Frog  1299 GMVLMQVDLLSGF--SLVP----EGIPMKYPIKKVD-YNEG-KINIYLDSLNQTE-VCINIPATR 1354

  Fly  1308 THAVANLKPSWVRLYDYYATERSATEFYHVD----TSLCDICHGNECGNMC 1354
            ...|...:.::|.:.|||...:.|...|:.:    .|.|..|: ::| |.|
 Frog  1355 DFKVGYTQEAFVYVIDYYDPGQRAIRSYNSEVMQQVSPCSFCN-DDC-NQC 1403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	27/84 (32%)
		A2M_N_2	411..542	CDD:285005	41/177 (23%)
		A2M	634..726	CDD:278630	31/91 (34%)
		A2M_2	859..1135	CDD:239227	91/286 (32%)
		A2M_comp	910..1135	CDD:284982	76/235 (32%)
		A2M_recep	1245..1335	CDD:284981	27/92 (29%)
cd109	XP_031758448.1	YfaS	57..1155	CDD:225248	304/1147 (27%)
		A2M	683..774	CDD:395153	31/91 (34%)
		A2M_2	895..1179	CDD:239227	91/292 (31%)
		A2M_recep	1298..1382	CDD:400149	27/92 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1138
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		mtm14080
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060