DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and c3a.4

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_002660623.3	Gene:	c3a.4 / 100331428	ZFINID:	ZDB-GENE-140822-3	Length:	1642	Species:	Danio rerio

Alignment Length:	1598	Identity:	394/1598 - (24%)
Similarity:	656/1598 - (41%)	Gaps:	366/1598 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYV--- 67
            :::.||...|||....||.:.||..|:..||..|.|...:          ..|.|||.|..|
Zfish     8 VAAVILSLPLLSFCQPLYILSAPNKLKLGSAERVFVEAQD----------YAGASLNVRISVRRF 62

  Fly    68 --DVQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNST------KLSFAPDL----------- 113
              |.:.::|.||.....|..:...|::| .|....|..|.      :..|...|
Zfish    63 KDDQREVASTSVTLTAGKNFQELVEIEV-PSNSFTFDKSAQQYAVLQAQFPNKLLQKQILVTFQS 126

  Fly   114 NWLYIQSDKATYKPGDKIQFRVLFLDKN-TRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYS 177
            ..:.:|:||..|.|...:.:||..|... |||  ....:::||...|...::| |.:.|..||.|
Zfish   127 GHIVLQTDKTIYTPDSTVHYRVFSLSPGMTRP--FQSGVRVEILTPDGISLES-KSVFPDGGVVS 188

  Fly   178 GELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIR----- 235
            |...::|....|.|.:.|..::  :...|:...|.:||:|.|||.:...|    :..|:.
Zfish   189 GTFGITDPASPGLWKLVAWHKNSPQKNFTSEFEVKEYVLPSFEVSLSPHK----AFFYVNDDSLL 249

  Fly   236 ATIKARYTFKKPVKGH---VVATIEGSSTEQSLP--------IDG---------EVNVEFP--IS 278
            ..|.|:|.|.:.|.||   |...:.....:.|:|        .||         ::...||  ..
Zfish   250 VDIHAKYLFGETVNGHGFVVFGVVTEDKGKISIPGSLQRVQIWDGSGTAQLTKRQILQTFPEIRQ 314

  Fly   279 ATAKRLLKITAIVTE---ELTDIKHNG----TAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVV 336
            ...|.|....:::||   |:.:....|    |:..|::..|       .|..::||:..:....|
Zfish   315 LVGKSLYISVSLLTESGSEMVEAHKKGIHIVTSPYTIYFKR-------TPQFFKPGMPFDVSVYV 372

  Fly   337 RNLDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPETCQSCLVTS-TFD----TAE 396
            .|.|.:|    :|.|...|....||....|   |.||...|..|....:..:|: |.|    :.:
Zfish   373 TNPDETP----AKNVKVEVNPGGVSGQTKA---NGIAKVTINTPGGSSTLEITARTSDPQLTSRQ 430

  Fly   397 NIER------YIYK--LNKPLMIAINTKKPQLRKLLKINI-------ISDTYLPYFILTVVARGN 446
            ..|:      |:.|  ....|.|.|:..:.::...:|:|:       :.|....|.||   :||.
Zfish   431 QAEKKMTAHAYVPKGGSRNYLHIGIDAAELRIGDSMKVNLNLGQSPGVRDQDFTYMIL---SRGQ 492

  Fly   447 IVLSLFQEMKEKKKSQ---EIEFEPTFALVPQATIFVHYII-DGVLMSDEKTVDIER-------- 499
            ||    |..:.|::.|   .:....|..:||......:|.: ...::||...||::.
Zfish   493 IV----QANRFKRRGQTLVSLSLPVTKDMVPSFRFVAYYHVGSSEVVSDSVWVDVKDTCMGSLKV 553

  Fly   500 DFENTIEILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTD 564
            :..:.:|:..     |.:|..|::..:|.:.|||:.||:.|.:|.:.:.:.:..|.:.:.::.|.
Zfish   554 EVHDPVEVYE-----PGEEFELRITGDPGAKVGLVAVDKGVYVLNNKHRITQSKIWDVVESHDTG 613

  Fly   565 LV---------------------------ILTNAN--------------INI------------- 575
            ..                           :.||:.              :|:
Zfish   614 CTAGSGKNSMQVFSDAGLLFESSSAGGTSVRTNSECPSSSRRRKRRETLVNLHKTLLDKYSGLAR 678

  Fly   576 ------------------YRSS---GGCYTNPGYTNCTGSLIGRTMFKNEPTK------NSGPVP 613
                              ||||   .|......:.:|...|   |..:.||.:      .|....
Zfish   679 ECCVDGLKALDVLDFSCEYRSSFILDGKECRDAFLDCCNRL---TSHREEPAEEEIFLGRSEDEE 740

  Fly   614 IVGSTRAQASLPPVRKLFPETWLFSNI-------------TDVGANGEYIIKETVPDTLTSWVIT 665
            .|.|....:     |.||||:||:..:             |.:..:|.::     .|::|:|.||
Zfish   741 FVNSDDIVS-----RTLFPESWLWEEVMLPKCLGNRQCQTTTLPKDGLWL-----KDSITTWEIT 795

  Fly   666 GFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSD 730
            ..|||...|:.|. :...:.|.:.|||...:|||..|.|.|.|..|:.|.....||.:|
Zfish   796 AISLSNTHGICVA-DVHEMIVAKNFFIDLKIPYSAVRNEQIEIKAIIHNLYSKAVKVRV------ 853

  Fly   731 GQYEFIET-------TNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKY 788
               |..||       :||.        |...|:.:.:.:...:.|:|.|..:|...:::.|.:..
Zfish   854 ---ELKETKDICSPASNKG--------RYAVTVTVASKSSYSVPFVIVPLALGRHAIEVKAAASG 907

  Fly   789 AG-DRLHQILKVEADGVQKYVNKAVLIN--------VQRLNRRSL---AP--PEKTIIIEKADNV 839
            .| |.:.:.|.|.::||...:::.:..|        ||.:....|   ||  |..|.:....|.:
Zfish   908 RGNDGVKKDLLVVSEGVLTKISENLQFNPFKKGDEDVQVIRSHILKDQAPNTPSSTYVQAIGDTI 972

  Fly   840 IEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQD---QEIE 901
               :.|:|..:.|.:       :..|:..|.|||||||......::|..||...|:..   ..:.
Zfish   973 ---TITIEKAISGAA-------MGSLIIQPGGCGEQNMMGLTMPVIATHYLDKTNQWHTVRAGLR 1027

  Fly   902 NKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLD 966
            ..|..|:..||..||.|:::||||:||....:  ||||||||.:.|..|:..|.||:||:.:.|.
Zfish  1028 QTATEYIRKGYNQELAYRKSDGSFAAWINRPS--STWLTAYVAKVFAMASDIIHIDQNVICSALR 1090

  Fly   967 FLV-SRQSTDGKFKELGMVIH-----NSHG--SPLALTSFVLLTFFENEE----YMPKYKHVIDR 1019
            :|: :||..:|.|:|...|||     |..|  |..::|:||.:...|...    .:......|.:
Zfish  1091 WLIMNRQLPNGVFRENAPVIHGEMTGNVQGSNSEASMTAFVTIALQEGRSRCNGQVSSLDSSIYK 1155

  Fly  1020 AVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWW--TGSDKCKSSE 1082
            |:.::.:::.....||.:|:|:.||:.|.:.|...::.|..      .|...|  .||   .|..
Zfish  1156 AIAYLKSQLQGLINPYAVAMASYALANANSLNKQVLMSKAS------ADKSHWPVPGS---SSFT 1211

  Fly  1083 VETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHA-STEAI 1146
            :|.:||.||||::.:......|||:||.::|..|||:.::|.|::...|:.:|.:  || :.:.:
Zfish  1212 LEASSYALLALVKLHDYQNTAPIVNWLNNQRQYNGGYGTTQATIMVFQAVAEYRI--HAKNIKQL 1274

  Fly  1147 DIEFWHLNEDKKHVRVT-----KENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKE 1206
            |:|   |:...:.||.|     |.|:...||.::|.|.. :.:.|||.|.|.|.:...|....||
Zfish  1275 DLE---LSIRVEGVRPTVFTFSKNNDHLSQTAKIPSNKG-ITISAKGFGEASVTVVTEYYAKPKE 1335

  Fly  1207 AR---PSFKLTTTVKKSHKGRLILGICGTY-----TPIAASERNKTTNMALMQVQLPSGYVCDIE 1263
            :.   .:|:|..|.:|.::.| ..|...:|     |...:::|:.|  |:::.|.|.:|:|.|..
Zfish  1336 SSSTCKNFELELTFEKDNEVR-YQGATESYKLTINTRYLSADRDAT--MSILDVSLLTGFVVDEN 1397

  Fly  1264 PFADIEAISD-----VKRVETKNEDTE---VHIYFEKLS--PGDRKCLTLEAIYTHAVAN---LK 1315
               |::|:|.     :::.|...:.:|   :.||.:|:|  ..||....|     |.:.|   |:
Zfish  1398 ---DLKALSTGRDKLIQKFEMNKQLSERGSLIIYLDKISHTRKDRVAFRL-----HRIMNGGFLQ 1454

  Fly  1316 PSWVRLYDYYATERSATEFYH---VDTSLCDICHGNEC 1350
            |:.|.:|:||:.|....:|||   .:..|..||..:.|
Zfish  1455 PAGVTVYEYYSIENRCVKFYHPTRKEGGLQKICKNDVC 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	25/87 (29%)
		A2M_N_2	411..542	CDD:285005	34/149 (23%)
		A2M	634..726	CDD:278630	30/104 (29%)
		A2M_2	859..1135	CDD:239227	93/292 (32%)
		A2M_comp	910..1135	CDD:284982	78/238 (33%)
		A2M_recep	1245..1335	CDD:284981	27/102 (26%)
c3a.4	XP_002660623.3	A2M_N	131..222	CDD:280081	26/93 (28%)
		A2M_N_2	453..591	CDD:285005	34/149 (23%)
		ANATO	668..734	CDD:237984	10/68 (15%)
		A2M	756..855	CDD:278630	30/113 (27%)
		complement_C3_C4_C5	981..1264	CDD:239226	94/300 (31%)
		A2M_comp	1036..1264	CDD:284982	78/238 (33%)
		A2M_recep	1379..1474	CDD:284981	28/104 (27%)
		NTR_like	1494..1641	CDD:295338
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584196
Domainoid	1	1.000	48	1.000	Domainoid score	I11904
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.800