DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and C4B_2

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001229752.1	Gene:	C4B_2 / 100293534	HGNCID:	42398	Length:	1744	Species:	Homo sapiens

Alignment Length:	1671	Identity:	372/1671 - (22%)
Similarity:	627/1671 - (37%)	Gaps:	406/1671 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLW-LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEV--SVSLTGPSLN 62
            :|| ||.:|:..   .||.......:.:|..:......:|.|.:.:..|...|  ||.|..||.|
Human     3 LLWGLIWASSFF---TLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRN 64

  Fly    63 SRKYVDVQSMSSKSVRFDIPKLTEGDY-------ELKVMGSGGI-------EFQ----------- 102
            :         ...|.:.|....:|.|:       .||...|.|:       |.|
Human    65 N---------VPCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDS 120

  Fly   103 -------NSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQ 160
                   ....|.|:.....|::|:|:..|.||.::::||..||:..||:.....:.:|...|
Human   121 LSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHG-- 183

  Fly   161 NLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLT 223
             |....|::.....::..:..:.|....|.|.::|...|  |...:....|.|||:|.|||.:..
Human   184 -LRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITP 247

  Fly   224 AK----NVAASAGYIRATIKARYTFKKPVKGHVVATI-------EGSST------EQSLPIDGEV 271
            .|    .|......::..|:|||.:.|||:|  ||.:       :|..|      .|:..::|:.
Human   248 GKPYILTVPGHLDEMQLDIQARYIYGKPVQG--VAYVRFGLLDEDGKKTFFRGLESQTKLVNGQS 310

  Fly   272 NVEFPISATAKRLLKITAIVTEELTDIKHNGTAYVTVHQ--HRHKLEDLFW-------------- 320
            ::....:.....|.|:...:| :|..::....|.:..:.  ...:.|...|
Human   311 HISLSKAEFQDALEKLNMGIT-DLQGLRLYVAAAIIEYPGGEMEEAELTSWYFVSSPFSLDLSKT 374

  Fly   321 PTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVL-------CCQVSKNFSASLQNSIATEHIM 378
            ..|..||.....:.:||.:.|||.......|:..|.       ...:.:|...|.|.||.   |:
Human   375 KRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDIQQNTDGSGQVSIP---II 436

  Fly   379 LPETCQSC-LVTSTFDTAENIERY-----------IYKLNKPLMIAINTKKPQLRKLLKINI--- 428
            :|:|.... |..|.......|.|.           ...:.:|     :::.|::...|.:|:
Human   437 IPQTISELQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERP-----DSRPPRVGDTLNLNLRAV 496

  Fly   429 -ISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDGVLMSDE 492
             ...|:..|:.: :::||.||   |...:.|:....:.......|.|.......|......:::.
Human   497 GSGATFSHYYYM-ILSRGQIV---FMNREPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHPVANS 557

  Fly   493 KTVDIERD-FENTIEILTTNEALPR--DEVSLKVKTNPHSFVGLLGVDQSVLLL--RSGNDLNRD 552
            ..||::.. .|..:|:........|  :.|.|.::|:..:.|.|..:|.::...  :|...||..
Human   558 LRVDVQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNMG 622

  Fly   553 LILNNLATY---------STDLVILTNA-----------------------------NINIYRSS 579
            .:...:.:|         .:.|.:...|                             |:|..::.
Human   623 KVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVNFQKAI 687

  Fly   580 G---GCYTNP--------GYT------------------NCTGSLIGRTMFKNEPTKNSGPVPIV 615
            .   |.|.:|        |.|                  :|....:....|.....|.|......
Human   688 NEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCCQFAESLRKKSRDKGQA 752

  Fly   616 GSTRAQASLP----------PVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLS 670
            |..||...|.          |||..|||.||:...|   .:...|:...:||:||:|.|.|.|||
Human   753 GLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVET---VDRFQILTLWLPDSLTTWEIHGLSLS 814

  Fly   671 PQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEF 735
            ...||.|. .|.::|||:.|.:...||.||:|.|.:.:..:::|||..::...|.:...:|..
Human   815 KTKGLCVA-TPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEGLC-- 876

  Fly   736 IETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKY---AGDRLHQIL 797
                      ...|....:.:.:||.:.|.::|.:.|......:||:.|...:   .||.:.::|
Human   877 ----------LAGGGGLAQQVLVPAGSARPVAFSVVPTAAAAVSLKVVARGSFEFPVGDAVSKVL 931

  Fly   798 KVEADGVQKYVNKAVLINVQRLN-----RRSLAPPEKT--IIIEKAD--NVIEGSETVEFEVCGT 853
            ::|.:|.   :::..|  |..||     .|:|..|..:  .:|...|  :.:..:.:...:..|:
Human   932 QIEKEGA---IHREEL--VYELNPLDHRGRTLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGS 991

  Fly   854 SQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQ----DQEIENKAKRYVETGYQI 914
            ..|.....:..|:.||.|||||.|....|::.|..||. |..|    ..|.::.|...::.||..
Human   992 EGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLD-KTEQWSTLPPETKDHAVDLIQKGYMR 1055

  Fly   915 ELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFK 979
            ...:::.|||::||....:  ||||||:|::....|.:.:......|....::|:|:|..||.|:
Human  1056 IQQFRKADGSYAAWLSRGS--STWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSFQ 1118

  Fly   980 ELGMVIHNS-------HGSPLALTSFVL------LTFFENEEYMPKYKHV---IDRAVEFV---- 1024
            :|..|||.|       :...:|||:||.      |..|::|...|..:.|   |.:|..|:
Human  1119 DLSPVIHRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKASSFLGEKA 1183

  Fly  1025 ---VTEVHQSNEPYDLAIAALALSLARNRNAYKVL--DKLDKLATRRGDHKWW---TGSDKCKSS 1081
               :...|.:      ||.|.||:|.:.....:.:  :.|..:|...||:.:|   |||.....|
Human  1184 SAGLLGAHAA------AITAYALTLTKAPADLRGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVS 1242

  Fly  1082 E------------------VETTSYVLLALLEH----NISDEPKPIVDWLISKRNSNGGFVSSQD 1124
            .                  :|||:|.||.||.|    .::|:   ...||..:.:..|||.|:||
Human  1243 PTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEGKAEMADQ---AAAWLTRQGSFQGGFRSTQD 1304

  Fly  1125 TVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAK-- 1187
            ||:.:.||:.|.:.||.:.|.      .||..   :..|..|.||  :|.|..|..:::.|.:
Human  1305 TVIALDALSAYWIASHTTEER------GLNVT---LSSTGRNGFK--SHALQLNNRQIRGLEEEL 1358

  Fly  1188 -------------GQGRAQVQLTYRYNVA----------------------TKEARPSF------ 1211
                         |..:..:::...|||.                      |.||...:
Human  1359 QFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYEDYEYD 1423

  Fly  1212 -----------------------------KLTTTVKKSHKGRLILGICGTYTPIAASERNKTTNM 1247
                                         :....|.:..:.|:...:|     |..:.:...:.|
Human  1424 ELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVC-----IWRNGKVGLSGM 1483

  Fly  1248 ALMQVQLPSGY---VCDIEPFADIEAISD--VKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIY 1307
            |:..|.|.||:   ..|:|   .:.::||  |...||  |...|.:||:.: |..|:|:..||:.
Human  1484 AIADVTLLSGFHALRADLE---KLTSLSDRYVSHFET--EGPHVLLYFDSV-PTSRECVGFEAVQ 1542

  Fly  1308 THAVANLKPSWVRLYDYYATERSATEFYHVDTS---LCDICHGNEC 1350
            ...|..::|:...|||||..||..:.||...:.   |..:|....|
Human  1543 EVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVC 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	21/86 (24%)
		A2M_N_2	411..542	CDD:285005	25/137 (18%)
		A2M	634..726	CDD:278630	32/91 (35%)
		A2M_2	859..1135	CDD:239227	95/329 (29%)
		A2M_comp	910..1135	CDD:284982	78/274 (28%)
		A2M_recep	1245..1335	CDD:284981	31/94 (33%)
C4B_2	NP_001229752.1	A2M_N	141..233	CDD:280081	22/94 (23%)
		A2M_N_2	478..610	CDD:285005	26/140 (19%)
		ANATO	686..750	CDD:237984	9/63 (14%)
		A2M	782..869	CDD:278630	32/90 (36%)
		complement_C3_C4_C5	996..1315	CDD:239226	95/330 (29%)
		A2M_comp	1051..1317	CDD:284982	79/276 (29%)
		A2M_recep	1481..1570	CDD:284981	31/94 (33%)
		NTR_complement_C4	1588..1742	CDD:239639	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020