Protein Alignment Tep1 and c3

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_031755344.1
• Gene: c3 / 100216255
• XenbaseID: XB-GENE-486274
• Length: 1658
• Species: Xenopus tropicalis
• Alignment Length: 1616
• Identity: 379/1616 - (23%)
• Similarity: 649/1616 - (40%)
• Gaps: 390/1616 - (24%)

  Fly     5 ILSSTILHCVLLSNANGLYSVLAPKTLRS-------------NSAYNVVVAIHNTTRTTEVSVSL 56
            :||.::|..|..|.|....|::.|..||:             |:|:.|.:.||...: .:::::.
 Frog     5 LLSLSLLLLVSGSYAQPQCSLITPNLLRAESEETIIIDAQGQNAAFEVEIIIHEFPQ-KKLNLAS 68

  Fly    57 TGPSLNS-RKYVDVQSMSSKSVRFDIPKLTEG-DYELKVMGSGGIEFQNSTKLSFAPDLNWLYIQ 119
            ...:||| .|::...::...|.  |:||..:. .|....:.|.....:....||:  ...::::|
 Frog    69 AKVTLNSDNKFLGTATVKIPSA--DVPKDKQNKQYVYVSLKSNVCALEKVVMLSY--HSGYIFLQ 129

  Fly   120 SDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAK-GVYSGELQLS 183
            :||..|.||..:.:|:..::...:|  |.|.:.||....|..::|....::.:| |:.|...:|.
 Frog   130 TDKTIYTPGSTVLYRIYSMNYKMQP--ISKTLIIEFVTPDGVIVKRDSILQDSKSGIISLSHKLP 192

  Fly   184 DRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLTAKN-VAASAGYIRATIKARYTFK 245
            :...||.||::|..:|  :...|....|.:||:|..|:::....| ..|.|......|.|:|.:.
 Frog   193 ELLSLGVWTISAKYEDTPQQNYTTNFEVKEYVLPSMEIILKPDTNFFYADANSFGVDIHAQYLYG 257

  Fly   246 KPVKGH--VVATIEGSSTEQSLP--------IDGEVNVEFPISATAKRLLK-----------ITA 289
            |.|.|:  |:..|...:.::.:|        .|||...|.......|...|           ..:
 Frog   258 KHVDGYAFVLFGIRKDNVKKGIPESLTRVRIDDGEGRAELKREDLVKYFAKQEDMLQYCLYVTVS 322

  Fly   290 IVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPT--HYRPGVSSEFKTVVRNLDGSPVMDSSKMVN 352
            :|||..:|:.......:.:....:|:  ||..|  :::||:..:....|.|.||||
 Frog   323 VVTETGSDMVEAEIECINIVTTPYKI--LFTRTSKYFKPGMPFDMMVYVTNPDGSP--------- 376

  Fly   353 FNVLCCQVSKNFSASLQNSIATEHIMLPETCQSCLVTS-TFDTAENIERYIYKLNKPLMIAINTK 416
                          :.:.::|.|...:..|.|:...|. |.:|..:|:|        |.|.:.||
 Frog   377 --------------ARRITVAAEPGNIEGTTQADGTTRLTMNTRPDIDR--------LHITVKTK 419

  Fly   417 KPQL---------------------RKLLKINIISDTYLP----------------------YFI 438
            .|.|                     ...|.|:|......|                      .|.
 Frog   420 DPVLPAARQATATMTATAYRPSKAQGNYLHISIAGSEIKPGENIPVNFNIRNTDAGVQNLIQQFT 484

  Fly   439 LTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDG----VLMSDEKTVDI-- 497
            ..:::||.||....|..:..:....:....|.||:|...|..:||:..    .::||...||:
 Frog   485 YLIMSRGRIVKVGRQARQPGQPFVTMSLSVTEALIPSFRIVAYYIVSSGGARDVVSDSLWVDVVD 549

  Fly   498 ----------ERDFENTIEILTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRS------- 545
                      ::|.:|.|:       .|...:.||::.:..|:|||:.||:.|.:|.|
 Frog   550 ECMGTLSVTGDKDRDNAIQ-------TPGSPMKLKLRADHKSYVGLVAVDKGVYVLNSKFKNTQK 607

  Fly   546 ---------------GNDLNRDLILNNLATYSTDLVILTNANIN-IYRSSGGC------------ 582
                           |:..|.:.:.::     ..|.:.|:...| ..||...|
 Frog   608 KVWDSVEKSDIGCTPGSGANSEGVFSD-----AGLALQTSFGTNTAQRSEAHCPAPAQRRKRSSV 667

  Fly   583 ------------YTNPGYTNCTG----SLIGRT-------------------------------- 599
                        |.:.....|..    :|:|.|
 Frog   668 AIIEIKAGKASEYKDKAKKCCLDGMQENLMGHTCERRARYILDGKECVDAFVDCCKYYEKKREAE 732

  Fly   600 -MFKNEPTKNSG--------PVPIVGSTRAQASLPPVRKLFPETWLF---SNITDVGANGEYIIK 652
             :.|:|.|....        ...||..|.           |||:|.:   ..:....|||  |..
 Frog   733 RLSKDEDTLGRSDEDDEYMLDSDIVSRTE-----------FPESWFWKVEQMVEKADANG--IST 784

  Fly   653 ET----VPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVF 713
            :|    :.|::|:|.:...|||...||.|.: |..|:|.:.|||...|||||.|.|.:.|..|::
 Frog   785 KTLNVFLKDSITTWEVLAVSLSETKGLCVAQ-PYEIKVMKDFFIDLKLPYSVVRNEQVEIRAILY 848

  Fly   714 NYLGMDVKAKVLMDNSDGQYEF--IETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVG 776
            ||....:|.:|.:.::.   ||  :.|..|         :.::.:||.|.:...:..:|.|..:|
 Frog   849 NYRNDRIKVRVELTHNP---EFCSLATPKK---------KYRQEVWIGALSSTAVPMVIVPLTLG 901

  Fly   777 LTTLKITA--ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEKADNV 839
            ...:::.|  ...:|.|.:.:.|||..:|::                  :|...||:|:|..
 Frog   902 QHDIEVKASVAGSFANDGVRKKLKVVPEGMR------------------IAQDVKTVILEPD--- 945

  Fly   840 IEGSETVEFE---------------------VCGTSQAPQLE------HLDDLVHLPCGCGEQNM 877
            ::|.:.|:.|                     :.||..:..:|      :::.|:.:|.|||||||
 Frog   946 VKGKDGVQEEEIKALNPKNVVPRTDIDTTITLQGTPISQMVEDAIDGNNMNHLIVVPAGCGEQNM 1010

  Fly   878 FNFVPSILALSYLK--------AKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDAL 934
            .:..||::|..||.        ..||::|.::|     ::.||..::.|::.|.|::||  .|..
 Frog  1011 ISTTPSVIATRYLDYSGQWERIGVNRREQALKN-----IKQGYAQQMTYRKPDNSYAAW--KDRP 1068

  Fly   935 GSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLV-SRQSTDGKFKELGMVIHN------SHGSP 992
            .|||||.||.:.|..|.:::||:.|||...:.:|: .||..||.|.|...|||.      :.|:.
 Frog  1069 ASTWLTGYVAKVFGMAQEFVDIEANVLCGAIKWLILERQKPDGLFYENAPVIHQEMVGGITTGAA 1133

  Fly   993 LA---LTSFVLLTFFENE----EYMPKYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNR 1050
            .|   ||:|:::...|.:    |::...:..||:|..::..:.....:||.:||.:.||:||...
 Frog  1134 EADSSLTAFIVIAMLECQRTCNEHVNNLQVSIDKATSYLTGQYPGLRKPYSIAITSYALALAGKL 1198

  Fly  1051 NAYKVLDKLDKLATRRGDHKWWTGSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNS 1115
            ...|.|     ::...||..|.....:..|  :|.|||.||.||:.........||.||..:|..
 Frog  1199 PNTKKL-----MSVSIGDTHWEEPGKRFIS--LEMTSYALLTLLKMKEYGPTGGIVRWLNEQRYY 1256

  Fly  1116 NGGFVSSQDTVVGIMALTKYELQSHASTEA-IDIEFWHLNEDKKHV--RVTKENEFKVQTHQLPE 1177
            ...:.|:|.|:|...||.:|:.......|. :|:.. ||.|.::.:  |:..:|....::.:...
 Frog  1257 GAVYGSTQATIVMFQALAQYQTDVPGLNELNLDVSL-HLPERQQPLTYRINLDNALLARSAETRL 1320

  Fly  1178 NTN-EVKLLAKGQGRAQVQLTYRYNVATKEARPS-FKLTTTVKKSHKGRLILGICGTYTPIAASE 1240
            |.: .||...||||..:|...|...:..||.:.| |:|:..||:....|...|...|.: |.|..
 Frog  1321 NQDFVVKAKGKGQGTIRVVTVYHALLTEKERKCSNFELSVKVKEEKIARRPEGARSTVS-IEACA 1384

  Fly  1241 R---NKTTNMALMQVQLPSGYVCDIEPFADI-----EAISDVKRVETKNEDTEVHIYFEKLSPGD 1297
            |   .....|:::.:.:.:|:..|.|....:     :.||..:..:..||...:.:|.:|:|..:
 Frog  1385 RYLGKDDATMSIIDISMMTGFSPDTESLDRLMKGVDKYISKYEVNKGANEKGTLILYLDKISNTE 1449

  Fly  1298 RKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTS------LC--DIC 1345
            .:|:...|.....|..::|:.|.:||||..|...|:||||:..      :|  |||
 Frog  1450 EECVKFYAHQYFEVGFIQPASVTVYDYYTPENRCTKFYHVEEGSALLGRICQDDIC 1505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	309/1325 (23%)
		A2M_2	859..1135	CDD:239227	94/303 (31%)
		A2M_recep	1243..1336	CDD:462226	23/97 (24%)
c3	XP_031755344.1	MG1	20..120	CDD:465508	19/102 (19%)
		MG2	125..220	CDD:426464	25/96 (26%)
		MG3	222..306	CDD:465509	21/83 (25%)
		MG4	348..424	CDD:465507	25/108 (23%)
		A2M_BRD	448..598	CDD:462235	34/156 (22%)
		ANATO	676..733	CDD:237984	5/56 (9%)
		A2M	765..861	CDD:459711	34/98 (35%)
		complement_C3_C4_C5	991..1276	CDD:239226	93/298 (31%)
		A2M_recep	1391..1488	CDD:462226	23/96 (24%)
		NTR_complement_C3	1507..1656	CDD:239638