Protein Alignment Tep1 and c4a

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001107156.1
• Gene: c4a / 100135012
• XenbaseID: XB-GENE-478881
• Length: 1683
• Species: Xenopus tropicalis
• Alignment Length: 1574
• Identity: 359/1574 - (22%)
• Similarity: 629/1574 - (39%)
• Gaps: 359/1574 - (22%)

  Fly    14 VLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSR---KYVDVQSMSSK 75
            |||:..|| |::||...|.|.                    .||...||.|   :||.:
 Frog    80 VLLNKGNG-YTILADLMLTSQ--------------------RLTTCKLNERRDDRYVQL------ 117

  Fly    76 SVRFDI----PKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVL 136
            .|:.||    ||:                    ..:..|....:|:||:||:.|.|.:.:..|:.
 Frog   118 VVKSDIFGKQPKV--------------------VSIPVAYQRGYLFIQTDKSIYTPKEAVHIRLF 162

  Fly   137 FLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKG-VYSGELQLSDRPVLGNWTVTATVQD- 199
            .||...||.  ::.:.:.:.:.....::..:.|  :|| |.:..|::.|....|.|.::|..:|
 Frog   163 TLDHVLRPT--EELVTLSVFNAQGFQVRKVEMI--SKGSVVAENLRIPDISTPGVWKISARYRDA 223

  Fly   200 -EGKVTNVLVVDKYVVPKFEVVVLT----------------------AKNVAASAGYIRATIKA- 240
             |...|....|..||:|.|||.::.                      .:|||..| |:|..|.|
 Frog   224 PETNFTAEFEVKPYVLPNFEVKIIPEVPYFLMTKDSFTFRVEARYVYGENVAGVA-YVRVGITAQ 287

  Fly   241 ---RYTF----KKPVKG--HVVATIEGSSTEQSLPIDGEVNVEFPISATAKRLLKITAIVTE-EL 295
               ||..    |:...|  :...||:.:..::.:..|....:...:...|..:.|.:.::.| ||
 Frog   288 NGKRYMLRGLEKQTTLGDENTAITIKMADIKEKIQQDMGNLLGASLYIAASVIEKASGVLEEKEL 352

  Fly   296 TDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPVMD-SSKMVNFNVLCCQ 359
            |.:|...:.|        ||:......::.||..::....|..:||||.:. |..:...||...:
 Frog   353 TSVKFVSSPY--------KLDLSRTKRYFIPGAPAQIVVEVSLIDGSPAVGVSVSLSKSNVQLFE 409

  Fly   360 VSKNFSASLQNSIATEHIMLPETCQSCLVT--STFDTAENIER-----YIYKLNKPLMIAI---- 413
            ...:     ...:.|.|:......:.|.:|  :..|:....||     |..|.|..|.|.:
 Frog   410 FKTD-----DKGVVTFHVNTASNEKKCDITVKANADSGSETERITLLPYTSKANSYLYINVPNQV 469

  Fly   414 ----NTKKPQLRKLLKIN-IISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALV 473
                ::.|..|:.::..| .:...|  |.:|.   :|.:   |.....::.:..|:....|..::
 Frog   470 LNPGSSVKVSLKAIISNNQNVGKIY--YMVLN---KGQL---LSMASIQRAEVNEMSIAVTSTMI 526

  Fly   474 PQATIFVHYIIDGVLMSDEKTVDIERDFENTIEILTTNEAL-PRDEVSLKVKTNPHSFVGLLGVD 537
            |...|...|..:..::::...||:....|..:|:....:.: |.:...|:|:....:.|.|..||
 Frog   527 PSFRIIAFYYHESEIIANSVWVDVTDVCEGKLELHANKQIIEPGEAFKLEVRAEGKASVSLSAVD 591

  Fly   538 QSVLLLRSGNDLNRDLILNNLATY--------STDLV-ILTNANINIYRSSG-------GC---- 582
            .:|.:|...|.|....:...:..|        ..|.: :||:|.:....|:|       ||
 Frog   592 TAVYILNPKNKLTPQKMFKAMNAYDLGCSPGGGKDFINVLTDAGLAFVSSAGYSQINELGCRVHQ 656

  Fly   583 ----------------YTNPGY------------------------------TNCTGSLIG---- 597
                            |:.|..                              |:|.|..:.
 Frog   657 RKKRAIDFQALTQQKAYSYPTTELQRCCQHGMMLPPRKMSRVCTQRAARVPDTSCRGVFLACCEY 721

  Fly   598 ----RTMFKNEPTKNSGPVPIVGSTR---------AQASLPPVRKLFPETWLFSNITDVGANGEY 649
                |.....|..|..|    .|.|:         |..|...:|..|||:||:..:...  ||
 Frog   722 AENLRKQMTLEKRKTQG----FGRTQNVDEFDEDFADESDIQMRSFFPESWLWRTVKVY--NG-- 778

  Fly   650 IIKET--VPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIV 712
            :|.|.  |||::|:|.|....:||:.|..:. .|.:::||:.|.|...:||||||.|.:.:..|:
 Frog   779 LISENVYVPDSITTWEIQAVGMSPEKGFCIA-EPLKVKVFKDFHIYLRVPYSVKRFEQMELRPIL 842

  Fly   713 FNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGL 777
            :||...|::.||.|:    |.|.|.:.....|:     ...|.:.:.||:...:.|::.|.....
 Frog   843 YNYNDKDLEVKVYME----QTEDICSPGSGESK-----PHIKQVTVAANSALPVPFVVVPIGKSN 898

  Fly   778 TTLKITAI-SKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEKADNVIE 841
            ..:.:.|: :....|.:.:.:|:..:|......|:.:|:...:.|:|:...|     |...|:|.
 Frog   899 PVVSVVALATSLVSDAVKKSMKIVKEGASVLEEKSYIIDPTDITRQSIDFEE-----ELPSNIIP 958

  Fly   842 GSE-------TVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLK-------- 891
            ..:       |::..:...:.:...:.:..|:.:|.||.||.|.:..|.:.||.||.
 Frog   959 DGDFHSSIKVTMDSPMNTINNSLGADGISKLIRVPYGCAEQTMISTSPGVYALRYLDHTEKWNLL 1023

  Fly   892 AKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDI 956
            ..:|:||.:||     :..||...|.:|:.|||:.||...  ..||||||:|::.......|||:
 Frog  1024 PPDRKDQGLEN-----MRQGYLRILQFKKTDGSYGAWVSR--ASSTWLTAFVVKVLSLCRNYIDV 1081

  Fly   957 DKNVLVAGLDFLVSRQSTDGKFKELGMVIH-------NSHGSPLALTSFVLLTFFENEEYMPK-- 1012
            :...:...:.:|.:.|:..|.|:|...|||       ::..:.:::|::|.:..:.:.:.:.:
 Frog  1082 NVEDIRRSVHYLTTMQTDKGAFQEKLTVIHQDMLGGASTIDAEVSITAYVTVALYHSLDALSEDN 1146

  Fly  1013 --YKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGD---HKWW 1072
              .|..|.:||:::.|::.....||.||:...||:|....:..|.......::..:||   .:.:
 Frog  1147 VAVKSSISKAVDYLRTKLDIVKHPYSLALTTYALTLTSKDSILKDNANNKLMSQAQGDPNKKELY 1211

  Fly  1073 TGSDKCKSSEVETTSYVLL-ALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYE 1136
            .|... .:..||||||||| .||..||.|..| :..||..::|..|||.|:||||:.:.||::|.
 Frog  1212 FGPPG-TALAVETTSYVLLITLLRGNIRDAEK-MYTWLSEQQNYGGGFRSTQDTVMALEALSEYW 1274

  Fly  1137 LQSHASTE-AIDIEFWHLNEDKKH---VRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLT 1197
            :::....: .::||...|  :|:|   .|:.||:..:.:...:....| ||:..||:|...|...
 Frog  1275 IRTFKQDDNTLEIEVNSL--EKQHSQKFRLRKEDSLQEELRSMGTKFN-VKVSGKGKGILTVMRM 1336

  Fly  1198 Y--------------------------------------------RYNVATKEARPSFKLTTTVK 1218
            |                                            |..:...:.|...:...|..
 Frog  1337 YNIIQMQNTSCTELGMDVTVTDASVDAGPDDQDDYDYDEEMADEPRDPIVWHDLRHRSRREVTFA 1401

  Fly  1219 KSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETKNED 1283
            |..:.:|:..:|    ....|.:...:.||::.:.:.||    |:|     .|.|:|::...:|.
 Frog  1402 KEKEVKLLYEVC----LWKKSSKVHLSGMAIVDITMLSG----IQP-----VIDDLKKLAESSEQ 1453

  Fly  1284 TEVH---------IYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDT 1339
            ...|         :||:|: |..|.|:|.||:.|..|:.|:|:...|||:|......|.||...:
 Frog  1454 YISHYEYQPGRLLLYFDKV-PDTRDCVTFEAVQTVKVSVLQPASAVLYDFYEPNIKCTVFYGAPS 1517

  Fly  1340 S---LCDICHGNEC 1350
            .   :..:|.|:.|
 Frog  1518 KPNFVSTLCSGDVC 1531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	294/1300 (23%)
		A2M_2	859..1135	CDD:239227	90/298 (30%)
		A2M_recep	1243..1336	CDD:462226	30/101 (30%)
c4a	NP_001107156.1	MG1	23..132	CDD:465508	22/98 (22%)
		YfaS	<139..1331	CDD:441940	293/1252 (23%)
		complement_C3_C4_C5	983..1273	CDD:239226	90/298 (30%)
		A2M_recep	1424..1513	CDD:462226	29/98 (30%)
		NTR_like	1531..1681	CDD:470599	1/1 (100%)