Protein Alignment Tep1 and a2m3b

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001093623.3
• Gene: a2m3b / 100101650
• ZFINID: ZDB-GENE-070720-15
• Length: 1455
• Species: Danio rerio
• Alignment Length: 1522
• Identity: 387/1522 - (25%)
• Similarity: 621/1522 - (40%)
• Gaps: 316/1522 - (20%)

  Fly    22 LYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVDVQSMSSKSVR-------- 78
            |:.|..|..:.|.|...:.|::...|.:..:::||          ||.|...::.||
Zfish    48 LFMVAFPSLIESGSDAKLCVSLLKHTGSLTITISL----------VDDQKTETQLVRQTSRRKLH 102

  Fly    79 ----FDIPKLTEGD--YELKVMGSG-GIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVL 136
                |..| :..||  ..::|:..| ..:....:|:.|...|...:||:||..|.||.|:..||:
Zfish   103 QCFTFQAP-IVNGDSVQTVRVVVQGPSFKMTEESKVMFRSYLPLTFIQTDKPLYNPGQKVNIRVV 166

  Fly   137 FLDKNTRP-------AVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVT 194
            .:.....|       .|::....|.||        .|.::.....:......|:.....|.:|:.
Zfish   167 TMSDQFVPQEQMYSLVVLEDLHGIRIR--------QWANVSSINWILELSHVLNPEAQTGTYTLK 223

  Fly   195 ATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVV------ 253
            |.:.|. .::....|.:||:|||:|.|...:..:.:...::....|:||:.:||.|.||
Zfish   224 AYIGDR-IISQSFDVKQYVLPKFDVTVNAPQTYSVADVGLKVEACAKYTYGQPVPGQVVVEVCRQ 287

  Fly   254 ---------------------------------ATIEGSSTEQSLPIDGEVNVEFPISATAKRLL 285
                                             ::..|:|.|.||.....|||.
Zfish   288 PFIYIQDPKVTSVCLSKSTKTNNTGCASLTLTTSSFFGTSLENSLQNSFVVNVN----------- 341

  Fly   286 KITAIVTEELTD--IKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSP----- 343
                 ||||.|.  |..:.|..:|....:....||  |..|..|.:...|..|.:.:|:|
Zfish   342 -----VTEEGTGFVISKSNTVSITFEVGKVTFVDL--PKFYDYGSTLNGKISVSDFNGNPINSKA 399

  Fly   344 --VMDSSKMVNFNVLCCQVSKNFSA--SLQNSI---ATEHIMLPETCQS---------------- 385
              |:|||...|..:.....:||..|  ||..:.   |..:::...|.||
Zfish   400 VYVLDSSTWPNKLLFNLTTNKNGLAMFSLDTTAFPKADLNLVASATPQSYFSYNSPYFTTDTRLV 464

  Fly   386 -CLVTSTFDTAENIERYIYKLNKPL----MIAINTKKPQLRKLLKINIISDT--YLPYFILTVVA 443
             ...|:..|.....:..|..|.:||    ..|:.         :|.:.:.:|  |....|..|::
Zfish   465 QLFQTAALDNPSFSDLSIVTLEQPLKCGSTYAVT---------VKYSFVGETGDYSADIIYMVMS 520

  Fly   444 RGNIVLSLFQEMK----EKKKSQEIEFEPTFA--LVPQATIFVHYIIDG-VLMSDEKTVDIERDF 501
            ||.|:|..|:.::    :...|..:.|:.:..  :.|...|....::.. .:::...:.|.|:.|
Zfish   521 RGVIILHGFKTVQALAFDTITSGTVSFDLSILANMAPMVQILAFCVLPSQTVVAGSASFDTEKCF 585

  Fly   502 ENTIEI-LTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTDL 565
            .|.:.: .:...|:|.:...|.|.....|..||..:|||||:|:||..|..:.:...|...|
Zfish   586 SNQVSLQFSPASAVPGEGNVLTVSAQAGSLCGLSAIDQSVLILQSGGRLTAEAVFGLLPVQS--- 647

  Fly   566 VILTNANINIYRSSGG------CY---------TNPGYTNCTGSLIGRTMFKNEPTKN------- 608
                     :|....|      |.         |:..|....|  :|..|..|.|.:.
Zfish   648 ---------LYDYPPGVEDQQDCLQVRPRRAVPTDQAYNTFKG--VGIKMATNLPVREPQCLTYR 701

  Fly   609 --------SGPV---------------PIVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYI 650
                    .|||               .|.||.........:|..|||||:: .:|.||.:|...
Zfish   702 RLNFYRNFRGPVMFAMDKVLAAPAAVSEIAGSPSGSPVDVTIRTFFPETWIW-QLTPVGDSGSTS 765

  Fly   651 IKETVPDTLTSWVITGFSLSPQS-GLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFN 714
            :..|||||:|:|....|.||... |||   .|:.:..|||||:...||||:.||||..:...|||
Zfish   766 VSLTVPDTITTWDAEAFCLSSNGFGLA---PPALLTAFQPFFLELTLPYSIIRGEVFELKATVFN 827

  Fly   715 YLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTT 779
            ||...:|.:|           ..|.:.|.:  |..:.:..:..: ||..:...:.:....:|...
Zfish   828 YLSQCIKVQV-----------TPTPSSNFT--LNSLDQSSSTLV-ANGRKTFKWALTASVIGTVN 878

  Fly   780 LKITA----ISKYAGDRLHQILKVEADGVQKYVNKAVLI---NVQRLNRRS-LAPPEKTIIIEKA 836
            :.|:|    ..:..|:|   ::.|.:.|....|.:::|:   .|:|...|| |..|:.:::.|..
Zfish   879 VTISAQANPSQELCGNR---VVTVPSRGRIDIVTRSLLVLAEGVKRTFTRSWLLCPKGSMLSEDV 940

  Fly   837 -----DNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQ 896
                 .|||:||......|.|......|::|.:|:.:|.|||||||....|:|..|.|||...:.
Zfish   941 RITFPKNVIQGSARCSVSVIGDIMGRALKNLANLLQMPYGCGEQNMIILGPNIYILRYLKVTAQL 1005

  Fly   897 DQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVL 961
            ...|::.|..|:::|||.:|||:.:|||||.:|..::  :|||||:|:|:|..|..:..||.|||
Zfish  1006 TPAIQDTAMTYLQSGYQGQLNYRHSDGSFSTFGYDES--NTWLTAFVMRTFGLARSFTYIDPNVL 1068

  Fly   962 VAGLDFLVSRQSTDGKFKELGMVIHNSH----GSPLALTSFVLLTFFENEEYMPKYKHVIDRAVE 1022
            .:..|:|:|:|.::|.|.:.|.:.||..    |..:.:|.:::....|..  :|....||.:|:.
Zfish  1069 QSAKDWLISKQGSNGCFVQQGTLYHNDMRGGVGDNVTMTGYIVAALLEIG--VPVTDPVITKALS 1131

  Fly  1023 FVVTEVHQSNEPYDLAIAALALSLA-RNRNAYKVLDKLDKLATRRGDHKWWTGSDKCKSSEVETT 1086
            |:...|......|..|:.|...||| ......::|:.|...|...|....|:.:....:..||.:
Zfish  1132 FLRPLVGNLGNTYVTALLAYTFSLAGETSTRAQLLNSLRNTAISEGTTLHWSQTTSGDTLAVEIS 1196

  Fly  1087 SYVLLALLEHNISDEP---------KPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYE--LQSH 1140
            :|||||:|    :.:|         ..||:||::::|..|||.|:|||||.:.|:..|.  :.|.
Zfish  1197 AYVLLAVL----TVQPVTTATLGYANRIVNWLVAQQNPYGGFTSTQDTVVALQAMALYASLVFSS 1257

  Fly  1141 ASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATK 1205
            ..:..:.::......|..:..||..|....|...|........::|.|.....||:...||:.|.
Zfish  1258 GGSSTVTVQSSVPAGDVYNFAVTPNNRLLYQESPLNNFPGTYSVVASGSTCVSVQVACFYNIPTP 1322

  Fly  1206 -----------------EARP-SFKLTTTVKKSHKGRLILGICGTYT-PIAASERNKTTNMALMQ 1251
                             :|.| :..||.|||              || |      ..||||.|:.
Zfish  1323 VVVAKTLSVVAKVTGNCQASPVNLMLTFTVK--------------YTGP------KPTTNMLLVD 1367

  Fly  1252 VQLPSGYVCDIEPFADIEAISD-VKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLK 1315
            :::.||:..|..........|. |:||:|  |...|.:|.:::..|.....:::...|.||.|||
Zfish  1368 IKVLSGFTADTSLLGSPPNFSPLVQRVDT--EGDRVLVYLQEVPKGVPVTYSIQLTQTVAVKNLK 1430

  Fly  1316 PSWVRLYDYYATERSATEFYHVDTSLC 1342
            |:.:.:||||....|....|   ||:|
Zfish  1431 PAVINVYDYYQRSESFETTY---TSVC 1454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	318/1248 (25%)
		A2M_2	859..1135	CDD:239227	99/289 (34%)
		A2M_recep	1243..1336	CDD:462226	29/93 (31%)
a2m3b	NP_001093623.3	None