DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep1 and a2ml2

DIOPT Version :9

Sequence 1:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster
Sequence 2:XP_021322235.1 Gene:a2ml2 / 100006993 ZFINID:ZDB-GENE-030131-1342 Length:1426 Species:Danio rerio


Alignment Length:1499 Identity:378/1499 - (25%)
Similarity:636/1499 - (42%) Gaps:300/1499 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SSTILHCVLLSNANGLYSVLAPKTLRS-NSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVDVQ 70
            :.|:...:.|.::|....:|..|..:. :..:|....:.......::.|.|.|.|.|        
Zfish    55 NKTLFMNIYLVHSNQSTLLLQEKAEQEFHRCFNFQAPLAEAESVQKIKVELQGESFN-------- 111

  Fly    71 SMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRV 135
                         :||   |.|||      |::...|:|        ||.||..|..|..:.|||
Zfish   112 -------------MTE---ERKVM------FKSYHPLTF--------IQMDKPFYIAGQTVNFRV 146

  Fly   136 LFLDKNTRPAVIDKPIK-IEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD 199
            :.:||:.||  :|:... :.:.|...|.|..|.::...:.:......|:.....|.:.|.|.: .
Zfish   147 VTMDKSFRP--LDQQYSAVVLEDSQDNRIGQWTNVSSTRWILQRSYDLNPEAREGTYKVKAFI-G 208

  Fly   200 EGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATIEGSSTEQS 264
            |..:::...|.|||:|||.|.|::...|:....::...:..:||:.|||.|.....:...:.:..
Zfish   209 ERMISHDFDVKKYVLPKFGVFVISPNPVSIDDEFMVIEVCGKYTYGKPVLGKSSVKVCRKTLDTH 273

  Fly   265 LPIDGEVNVEFPISATAKRL-----------------LKITAIVTEELTDI--KHNGTAYVTVHQ 310
            .|:..:.:.|...:..|...                 |.|.|.:|||.|:|  ..:.|..:|...
Zfish   274 SPLCVKESTEISKTGCANHTLALSVFFYPTHHQLLNDLHIEATITEEETEITMTQSNTISLTYEI 338

  Fly   311 HRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPV----------------------MDSSKMVNF 353
            .:....||  |..|..|...|.|..:....|:.|                      .||:.:.||
Zfish   339 GKVTFTDL--PKTYEYGSVIEGKVKLARFRGTAVPGKHIYILENYSWPPKVLLNLTTDSNGLANF 401

  Fly   354 NVLCCQVSK---NFSASLQNSIATEHIMLP------ETCQ-----SCLVTSTFD--TAENIERYI 402
            ::...:..|   |..||......:.....|      :|.|     :...|.||.  ..||||   
Zfish   402 SLNTLRFVKSDINLMASAYPGYRSYFQKSPYFNTDEKTVQFFPKPAASYTPTFSELIIENIE--- 463

  Fly   403 YKLNKPLM----IAINTKKPQLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEK----- 458
                :||.    |....|...:::.:||......|:      |::||.|:...:::::.|     
Zfish   464 ----QPLKCGTEITATVKYYFVKETVKIFNADIVYM------VLSRGVIIHHGYEKVEVKSSNAV 518

  Fly   459 -------KKSQEIEFEP-----TFALVPQATIFVHYIIDGVLMSDEKTVDIERDFENTIEI-LTT 510
                   |.|...:..|     .:.::|...|.:|          .:...:|:..:|.:.: .:.
Zfish   519 ASGTMSFKLSVGADVAPLVQILAYCVLPSENIAIH----------SENFHVEKCLKNKVSLQFSP 573

  Fly   511 NEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNL-----ATYSTDL----- 565
            .:|:|.::.:|::...|.|..||..||||||:|.||..|:.|.|.|.|     :.|.:.|     
Zfish   574 AKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLMLESGKRLDADKIFNLLPVKYGSGYPSSLPDEKE 638

  Fly   566 --VILTNANINIYRSS--------GGCYTNPGYTNCTGSLIGRTMFKNEPTKNSGPVPI---VGS 617
              .::.....||::||        .......|.:.|       .|:|........||.:   :| 
Zfish   639 CFYMMAVPIENIFKSSKRIGLKMATNLAVRSGTSTC-------EMYKKFSMFAILPVDLFRDIG- 695

  Fly   618 TRAQASLP-------PVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGL 675
             .|:.|:|       .||.:||:|||: .:.::..:|...:..|||||:|||....|.|| .:||
Zfish   696 -LAEDSVPHWTLFEENVRSVFPKTWLW-QLIEISDSGSAEVPVTVPDTITSWETEAFCLS-STGL 757

  Fly   676 AVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKV---------LMDNSDG 731
            .:. .|:::.||||||:..:||||:.|||:..:...|||||...:..||         |..:||.
Zfish   758 GLA-PPAQLTVFQPFFLELSLPYSIIRGEMFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDD 821

  Fly   732 QYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITA---ISKYAGDRL 793
            ||          |..|....||...||           :.|..:|:..:.:.|   .|:...|  
Zfish   822 QY----------SSCLCANGRKTFKWI-----------LTPSVIGVVNVTVRAEAEASQTVCD-- 863

  Fly   794 HQILKVEADGVQKYVNKAVLINVQRLNRRS----LAPPEKTIIIEKAD-----NVIEGSETVEFE 849
            ::|:.|...|....|.:::|:..:.:.:..    |..|:...::|:.|     ::||||.|....
Zfish   864 NEIVSVPERGRIDTVTRSLLVQAEGIKKAKTNSWLLCPKGDSLLEEIDLTLPKDMIEGSVTSSVS 928

  Fly   850 VCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQI 914
            |.|......|:.|...:......|.||:....|||..|.||:...:....|..||..::::|||.
Zfish   929 VIGDIVGRSLKKLHRTLWRIYRSGNQNIAILSPSIYILQYLENTKQLTSAIREKASSFLKSGYQR 993

  Fly   915 ELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFK 979
            :|.|:..:|::|.:|  :..|:.||||:|::||.:|.|||.||..::.:...:|:..|..:|.|.
Zfish   994 QLKYRHRNGAYSTFG--NGKGNAWLTAFVLKSFVKAQKYIYIDPQIIKSAKKWLIGTQDPEGCFI 1056

  Fly   980 ELGMVIHN-------SHGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEVHQSNEPYDL 1037
            :.|.:.:|       .|   :.:|:::..:..|.|..:.  ..||.:.:..:.:.:......|..
Zfish  1057 QHGRLFNNRLKGGVSDH---VTMTAYITASLLELETSVT--DPVIIKGLSCLRSVIKDVKNTYTT 1116

  Fly  1038 AIAALALSLARNRNA-YKVLDKLDKLATRRGDHKWWTGS---DKCKSSEVETTSYVLLALLEHNI 1098
            |:.|...||||:.|. .::.:||:.||...|....|:.|   |...|.:||.:||||||:|   .
Zfish  1117 ALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSASADDSDSLDVEISSYVLLAVL---T 1178

  Fly  1099 SDE--------PKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHAS--------TEAID 1147
            :|.        ...||.||:.::|:.|||.|:|||||.:.||:.|..:..:|        ..|.|
Zfish  1179 ADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSSTVTVQSAGD 1243

  Fly  1148 IEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVAT-KEARP-- 1209
            ..::::|:|.|.|         .|..||.....:.|:..||.....||:...||:.| ||.:.  
Zfish  1244 SHYFNVNQDNKLV---------YQEKQLANVPGKYKIEVKGSACVSVQMAQFYNILTPKEVKTLS 1299

  Fly  1210 -SFKLTTTVKKSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEA--- 1270
             ..|:....||:...:|:|.....|     ...::||||.::.|:|.||:..|........:   
Zfish  1300 IDVKIEGDCKKTFGNKLLLEFTVNY-----DGPHETTNMLIVDVKLLSGFTADDTTMFGSSSGFY 1359

  Fly  1271 ISDVKRVETKNEDTEVHIYFEKLS---PGDRKCLTLEAIYTHAVANLKPSWVRLYDYYAT-ERSA 1331
            :..|::|:.|  |..|.:|.:::.   |.:.:....:.::   |.||||:.:::||||.| ::|.
Zfish  1360 VPLVEQVDYK--DDHVIVYLKEVPKHFPVNYQIQMKQVLH---VMNLKPAVIKVYDYYQTSDQSE 1419

  Fly  1332 TEFY 1335
            ||:|
Zfish  1420 TEYY 1423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 22/85 (26%)
A2M_N_2 411..542 CDD:285005 30/148 (20%)
A2M 634..726 CDD:278630 38/100 (38%)
A2M_2 859..1135 CDD:239227 91/294 (31%)
A2M_comp 910..1135 CDD:284982 77/243 (32%)
A2M_recep 1245..1335 CDD:284981 28/96 (29%)
a2ml2XP_021322235.1 A2M_N 127..218 CDD:307790 24/101 (24%)
A2M_N_2 457..606 CDD:311575 37/171 (22%)
A2M 718..806 CDD:306673 37/90 (41%)
A2M <763..858 CDD:331860 34/115 (30%)
A2M_2 949..1223 CDD:239227 89/283 (31%)
A2M_recep 1331..1422 CDD:311553 27/95 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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