DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and LOC100006895

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_001923676.2	Gene:	LOC100006895 / 100006895	-ID:	-	Length:	1449	Species:	Danio rerio

Alignment Length:	1511	Identity:	387/1511 - (25%)
Similarity:	660/1511 - (43%)	Gaps:	247/1511 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 W--LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRK 65
            |  |:|...:|.||....|...:.|:.|..:.|.|...:..::.|...:..:::.|...:.::..
Zfish    16 WKGLLLIFFLLVCVNGKTARPSFMVMFPIVIESGSEAKLCASLLNPNESLVMNIYLNDGNQSTLL 80

  Fly    66 YVD-VQSMSSKSVRFDIP-KLTEGDYELKVMGSG-GIEFQNSTKLSFAPDLNWLYIQSDKATYKP 127
            ..: .:....:...|..| ...|...::||...| ..|.....|:.|.......:||:||..|.|
Zfish    81 LQEKAEQEFHRCFNFKAPLAKAETVQKIKVELQGKSFEMTEERKVMFKSYDPLTFIQTDKPIYIP 145

  Fly   128 GDKIQFRVLFLDKNTRPAVIDKPI-KIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNW 191
            |..:.||::.||||..|  :|:.. .:.:.|...|.|..|.::...:.:.....:|:.....|.:
Zfish   146 GQTVNFRIVTLDKNFAP--LDQQYSSVVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGTY 208

  Fly   192 TVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATI 256
            .: .|...|.:|.:...|.|||:|||||.|.....|:.....:...:.|:||:.:||.|.....:
Zfish   209 KL-KTFIGEMEVLHYFKVKKYVLPKFEVTVKKPNKVSVDEEELSIEVCAKYTYGQPVPGKSWVKV 272

  Fly   257 EGSS-----TEQSLPIDGEVNVEFP--------------ISATAKRLLK----ITAIVTEELTDI 298
            ..:|     |:...|:..|...|..              :::|.|..||    :.|:||||.|:|
Zfish   273 CRNSVPYFHTKDFNPLCSEETTEITKTGCAIHNFGVSVFLNSTLKERLKDSLHVEAVVTEEGTEI 337

  Fly   299 KHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSPV------------------- 344
            ....:..|.:.....|::.:..|..|..|...|.|..:.:...:|:
Zfish   338 TMAKSESVPLTYEIGKVKVIDLPNTYEHGSVIEGKIKLFDFKDAPIPNKEVYLLEGENWSSKLLL 402

  Fly   345 ---MDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPET----------CQSCLVTSTFDTAE 396
               .||..:.:|::....:||...:.:.|       :.|:|          .:.......|.||.
Zfish   403 NLTTDSDGLASFSLNTSSLSKKDISLIAN-------VYPDTRFRQYKTPYFSRDKKTVKLFQTAT 460

  Fly   397 NIERYIYKLNKPLMIAINTKKP-----QLRKLLKINIISDTYLPY---FILTVVARGNIVLSLFQ 453
            .......||     |..|.::|     ::...:|...:.:|...:   .:..|:::|.||...::
Zfish   461 PYSPTFSKL-----IIENIEQPIKCGTEITATVKYYFVGETVEDFNTDIVYIVLSKGVIVHHGYE 520

  Fly   454 EMKEKKK----SQEIEFEPTFA--LVPQATIFVHYIIDGV-LMSDEKTVDIERDFENTIEI-LTT 510
            :::.|..    |..:.||.:..  :.|...|..:.::... :::..|::|||:.|.|.:.: .:.
Zfish   521 KVEVKSSNGVASGTMSFELSVGADVAPVVRILAYCVLPSENIIAASKSLDIEKCFGNKVSLQFSP 585

  Fly   511 NEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLA------TYSTD----- 564
            .:|:|.::.:|::...|.|..||..||||||:|.||..|:.|.|.:.|.      .||.:
Zfish   586 AKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLILESGKRLDADKIFSLLPFQYVYYPYSAEDEQPC 650

  Fly   565 ------LVILTNANINIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTK---------------- 607
                  ..:||:   |:|.|.              ..:|..|..|...:
Zfish   651 LPVRPRRSVLTD---NVYNSL--------------KSVGLKMASNLAVRVPECLSFRGLTYHRFR 698

  Fly   608 ------NSGPVPI---VGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWV 663
                  .||.|.:   :.|:....|...:|.:|||||:: ::.:||.:|...:..|||||:|:|.
Zfish   699 DIVMYHTSGRVGLGSSIESSTFDNSAVTIRTIFPETWIW-DLAEVGDSGSTEVPVTVPDTITTWE 762

  Fly   664 ITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKV---- 724
            ...|.|| .:||.:. .|:::.||||||:..:||||:.|||:..:...|||||...:..||
Zfish   763 TEAFCLS-STGLGLA-PPAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPAP 825

  Fly   725 -----LMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITA 784
                 |..:||.||          |..|....|:...||           :.|..:|:..:.::|
Zfish   826 SSDYTLKASSDDQY----------SSCLCANGRQTFKWI-----------LTPSVLGVVNVTVSA 869

  Fly   785 ---ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQRLNRRS----LAPPEKTIIIEKAD----- 837
               .|:...|  ::|:.|...|....|.:::|:..:.:.:..    |..|:...:.|..|
Zfish   870 EAEASQTVCD--NEIVSVPERGRIDIVTRSLLVQAEGIEKTETNSWLLCPKGDSLSENVDLTVPK 932

  Fly   838 NVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIEN 902
            :|||||......|.|......|::|..|:.:|.|||||||....|:|..|.||:...:....|..
Zfish   933 DVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIRE 997

  Fly   903 KAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDF 967
            ||..::::|||.:||||..||::|.:|..|  |:|||||:|:|||.:|.||..||..::.:..|:
Zfish   998 KASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDW 1060

  Fly   968 LVSRQSTDGKFKELGMVIHN----SHGSPLALTSFVLLTFFENEEYMPKYKHVIDRAVEFVVTEV 1028
            |:||:.:||.|.:.|.:.:|    .....:.:|:::..:..|.|  .|....|:.:.:..:.:.:
Zfish  1061 LISRRDSDGCFIQQGRLFNNRMKGGVTDNVTMTAYITASLLELE--TPVTDPVVTKGLSCLRSVI 1123

  Fly  1029 HQSNEPYDLAIAALALSLARNRNA-YKVLDKLDKLATRRGDHKWWTGS---DKCKSSEVETTSYV 1089
            ......|..|:.|...||||:.|. .::..||:.||...|....|:.|   |...|.:||.:|||
Zfish  1124 EDVKNTYTTALLAYTFSLARDTNTRQQLFSKLEDLAISDGPLVHWSQSASADDSASLDVEISSYV 1188

  Fly  1090 LLALLEHNISDE--------PKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAI 1146
            |||:|   .:|.        ...||.||:.::|:.|||.|:|||||.:.||:.|..:..:|..:.
Zfish  1189 LLAVL---TADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSS 1250

  Fly  1147 DIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSF 1211
            .:...... |..|..|.::|:...|..||.....:..:..||.....||:...||:.|.....:.
Zfish  1251 TVTVQSAG-DSHHFDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQMAQFYNIPTPTEAKTL 1314

  Fly  1212 KLTTTV----KKSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDI-------EPF 1265
            .:...|    ||:....|:|.:..||.    ..:|: |||.::.::|.||:..|.       :.|
Zfish  1315 SIDAEVEGDCKKTFGQNLMLNVTVTYD----GPQNR-TNMVIVDIKLLSGFTADTSMLKTQRQSF 1374

  Fly  1266 ADIEAI--SDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYAT- 1327
            ..::..  :.|:|:::|  |..|.:|.|::...|...|.:.......|.||||:.:::||||.|
Zfish  1375 DSLDFFGHAPVERIDSK--DDHVLVYLEEVLKEDPVNLQIGLNQIIQVKNLKPAVIKVYDYYQTS 1437

  Fly  1328 ERSATEFYHVDTSLCD 1343
            ::|..|:    :|.|:
Zfish  1438 DQSEMEY----SSHCE 1449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	22/85 (26%)
		A2M_N_2	411..542	CDD:285005	33/146 (23%)
		A2M	634..726	CDD:278630	38/100 (38%)
		A2M_2	859..1135	CDD:239227	103/291 (35%)
		A2M_comp	910..1135	CDD:284982	84/240 (35%)
		A2M_recep	1245..1335	CDD:284981	29/99 (29%)
LOC100006895	XP_001923676.2	A2M_N	134..225	CDD:280081	24/93 (26%)
		A2M_N_2	471..616	CDD:285005	31/144 (22%)
		A2M	734..822	CDD:278630	37/90 (41%)
		A2M_2	953..1239	CDD:239227	103/292 (35%)
		A2M_comp	1005..1241	CDD:284982	85/242 (35%)
		A2M_recep	1347..1444	CDD:284981	28/98 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010