DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep1 and si:dkey-105h12.2

DIOPT Version :9

Sequence 1:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_001345438.6	Gene:	si:dkey-105h12.2 / 100006782	ZFINID:	ZDB-GENE-131118-9	Length:	1447	Species:	Danio rerio

Alignment Length:	1518	Identity:	392/1518 - (25%)
Similarity:	662/1518 - (43%)	Gaps:	263/1518 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 W--LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPS----- 60
            |  |:|..::|.||....|...:.|:.|..:.|.|...:..::.|...:..:::.|...:
Zfish    16 WKGLLLLFSLLICVNGKMAEPSFMVIFPAVIESGSEAKLCASLLNPNESLVMNIYLVHGNQSTLL 80

  Fly    61 ------------------LNSRKYVDVQSMSSKSVRFDIPKLTEGDYELKVMGSGGIEFQNSTKL 107
                              |...:.|.:..:..:...|   |.||   |.|||      |::...|
Zfish    81 LQEKAEQEFHRCFNFKAPLAVAESVQIMKVELQGESF---KRTE---ERKVM------FKSYHPL 133

  Fly   108 SFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPI-KIEIRDGDQNLIKSWKDIKP 171
            :|        ||:||..|.||..:.||::.||||..|  :|:.. .:.:.|...|.|..|.::..
Zfish   134 TF--------IQTDKPIYIPGQTVNFRIVTLDKNFAP--LDQQYSSVVLEDSQDNRIGQWTNVSS 188

  Fly   172 AKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRA 236
            .:.:.....:|:.....|.:.:.|.: .|..:::...|.|||:|||||.|.....|:.....:..
Zfish   189 TRWILQRSYELNPECREGTYKLKAFI-GERMISHYFKVKKYVLPKFEVAVKKPNKVSVDEEELLI 252

  Fly   237 TIKARYTFKKPVKGHVVATIEGSS-----TEQSLPIDGEVNVE----------FPISATAKRLLK 286
            .:.|:||:.:||.|.....:..:|     |:...|:..|...|          |.||......||
Zfish   253 EVCAKYTYGQPVPGKSWVKVCRNSMRHFHTKDFNPLCSEETTEITKAGCAIHNFGISVFLNSTLK 317

  Fly   287 --------ITAIVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRNLDGSP 343
                    :.|:||||.|:|....:..|.:.....|:..:..|..|..|...|.|..:.:...:|
Zfish   318 ERLMNSLHVEAVVTEEGTEITMTKSESVPLTYEIGKVTLIDLPKTYEHGSVIEGKIKLFDFKDAP 382

  Fly   344 V----------------------MDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPETCQSC 386
            :                      .||..:.:|::....:||...:.:.:.....|....:|....
Zfish   383 IPNKEVYLLEGENWSSKLLLNLTTDSDGLASFSLNTSSLSKKDISLIASVYPDTHFREYKTPYFS 447

  Fly   387 LVTSTFDTAENIERYIYKLNKPLMIAINTKKP-----QLRKLLKINIISDTYLPY---FILTVVA 443
            ....|....:..:.|...|::  :|..|.::|     ::...:|...:.:|...:   .:..|::
Zfish   448 TDKKTVQVFQTADPYTPILSE--LIMENIEQPIKCGTEITATVKYYFVGETVEGFNTDIVYIVLS 510

  Fly   444 RGNIVLSLFQEMKEKKKSQE-----IEFEPTFA--LVPQATIFVHYIIDGV-LMSDEKTVDIERD 500
            :|.||...:::::.|..|..     :.|:.:..  :.|...|.|:.::... :::..|.:.||:.
Zfish   511 KGVIVRHGYEKLEVKSSSNRVSSGTVSFKLSVGADVAPVVQILVYCVLPSENIVAANKRLSIEKC 575

  Fly   501 FENTIEI-LTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGNDLNRDLILNNLATYSTD 564
            |.|.:.: .:..:|:|.::.:|::...|.|..||..||||||:|.||..|:.|.|.|.|...|..
Zfish   576 FGNKVSLQFSPAKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLILESGKRLDADKIFNLLPVQSVS 640

  Fly   565 LV------------------ILTNANI-------------NIYRSSGGCYTNPGYTNCTGSLIGR 598
            ..                  :||: |:             |::.....|.:..|.|  ....|.|
Zfish   641 YYPYSVEDEQPCLHVRPRRSVLTD-NVYENLKRVGLKMASNLFVRVPECLSYRGLT--YHRKIAR 702

  Fly   599 TMFKNEPTKNSGPVPIVGSTRAQASL-----PPV--RKLFPETWLFSNITDVGANGEYIIKETVP 656
            |...|.....      :|.:|.::||     |.|  |.:|||||:: ::.:||.:|...:..|||
Zfish   703 TGVVNTARSR------MGFSRPESSLVNRDSPTVTIRTVFPETWIW-DLAEVGDSGSAEVPVTVP 760

  Fly   657 DTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVK 721
            ||:|:|....|.|| .:||.:. .|:::.||||||:..:||||:.|||:..:...|||||...:.
Zfish   761 DTITTWETEAFCLS-STGLGLA-PPAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIM 823

  Fly   722 AKV---------LMDNSDGQYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGL 777
            .||         |..:||.||          |..|....|:...||           :.|..:|:
Zfish   824 VKVSPAPSSDYTLKASSDDQY----------SSCLCANGRQTFKWI-----------LTPSVLGV 867

  Fly   778 TTLKITA---ISKYAGDRLHQILKVEADGVQKYVNKAVLINVQ-----RLNRRSLAP------PE 828
            ..:.::|   .|:...|  ::|:.|...|....|.:::|:..:     ..|...|.|      .|
Zfish   868 MNITVSAEAEASQTVCD--NEIVSVPERGRIDIVTRSLLVQAEGTEKTETNSWLLCPKGDSLSEE 930

  Fly   829 KTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAK 893
            ..:.:.|  :|||||......|.|......|::|..|:.:|.|||||||....|:|..|.||:..
Zfish   931 MNLTLPK--DVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENT 993

  Fly   894 NRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDK 958
            .:....|..||..::::|||.:||||..||::|.:|..|  |:|||||:|::||.:|.||..||.
Zfish   994 KQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNTWLTAFVLKSFGKAQKYTFIDP 1056

  Fly   959 NVLVAGLDFLVSRQSTDGKFKELGMVIHN----SHGSPLALTSFVLLTFFENEEYMPKYKHVIDR 1019
            .::.:..|:|:||:::||.|.:.|.:.:|    ...:.:.:|:::..:..|.|  .|....||.:
Zfish  1057 QIIQSAKDWLISRRNSDGCFIQQGRLFNNRMKGGVNNNVTMTAYITASLLELE--TPVTDPVITK 1119

  Fly  1020 AVEFVVTEVHQSNEPYDLAIAALALSLARNRNA-YKVLDKLDKLATRRGDHKWWTGS---DKCKS 1080
            .:..:.:.:......|..|:.|...||||:.|. .::.:||:.||...|....|:.|   |...|
Zfish  1120 GLSCLRSVIEDVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSASADDSAS 1184

  Fly  1081 SEVETTSYVLLALLEHNISDE--------PKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYEL 1137
            .:||.:||||||:|   .:|.        ...||.||:.::|:.|||.|:|||||.:.||:.|..
Zfish  1185 LDVEISSYVLLAVL---TADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYAT 1246

  Fly  1138 QSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNV 1202
            :..:|..:..:...... |..|..|.::|:...|..||.....:..:..||.....||:...||:
Zfish  1247 KVFSSDGSSTVTVQSAG-DSHHFDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQMAQFYNI 1310

  Fly  1203 ATKEARPSFKLTTTV----KKSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDI- 1262
            .|.....:..:...|    ||:....|:|....||....|.     |||.::.::|.||:..|.
Zfish  1311 LTPTEAKTLSIDAEVEGDCKKTFGKSLLLNFTVTYDGPQAK-----TNMVIVDIKLLSGFTADTS 1370

  Fly  1263 ------EPFADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRL 1321
                  :.:|     |.|:|:::|  |..|.:|.:::...|...|.:.......|.||||:.:::
Zfish  1371 MLKTQQQSYA-----SPVERIDSK--DDHVLVYLKEVPKADPVNLQIGLNQIIQVKNLKPAVIKV 1428

  Fly  1322 YDYYAT-ERSATEFYHVDTSLCD 1343
            ||||.| ::|..|:    :|.|:
Zfish  1429 YDYYQTSDQSEMEY----SSHCE 1447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	22/85 (26%)
		A2M_N_2	411..542	CDD:285005	32/147 (22%)
		A2M	634..726	CDD:278630	38/100 (38%)
		A2M_2	859..1135	CDD:239227	103/291 (35%)
		A2M_comp	910..1135	CDD:284982	84/240 (35%)
		A2M_recep	1245..1335	CDD:284981	29/97 (30%)
si:dkey-105h12.2	XP_001345438.6	A2M_N	134..225	CDD:280081	24/101 (24%)
		A2M_N_2	476..617	CDD:285005	29/140 (21%)
		A2M	739..827	CDD:278630	37/90 (41%)
		A2M_2	958..1244	CDD:239227	103/292 (35%)
		A2M_comp	1010..1246	CDD:284982	85/242 (35%)
		A2M_recep	1352..1442	CDD:284981	28/96 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584160
Domainoid	1	1.000	217	1.000	Domainoid score	I2610
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1243
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6406
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.800