Protein Alignment Tep1 and a2m2a

DIOPT Version :10

• Sequence 1: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_001921519.4
• Gene: a2m2a / 100003785
• ZFINID: ZDB-GENE-131118-12
• Length: 1437
• Species: Danio rerio
• Alignment Length: 1545
• Identity: 382/1545 - (24%)
• Similarity: 665/1545 - (43%)
• Gaps: 331/1545 - (21%)

  Fly     2 LW--LILSSTILHCVLLSNANGLYS-----VLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGP 59
            :|  |||:      ::|.:.||..|     |..|..:||.|...:..::.|...:..:::.|...
Zfish     8 VWKGLILA------IILLSVNGQMSTPSFMVTFPAVIRSGSEAKLCASLLNPNESLVMNIYLNQE 66

  Fly    60 SLNS------------------RKYVDVQSMSSKSVRFDIP--KLTEGDYELKVMGSGGIEFQNS 104
            :.::                  ...|:.:|:.:..|.....  |:||   |.|||      .:..
Zfish    67 NQSTLLLQEKAEQEFHRCFNFQAPLVEAESVQTMKVELQGKNFKMTE---ERKVM------LRRY 122

  Fly   105 TKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPI-KIEIRDGDQNLIKSWKD 168
            ..|:|        ||:||..|.||..:.|||:.:|.|..|  :|:.. .:.:.|...|.|..|.:
Zfish   123 YPLTF--------IQTDKPIYIPGQTVFFRVISMDANFVP--LDQTYDTVVLEDSQDNRIGQWTN 177

  Fly   169 IKPAKGVYSGELQLSDRPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGY 233
            :...:.:.....:|:.....|.:.:.|.: .|..::|...|..||:|||:|.:...:..:.....
Zfish   178 VSSTRWILQLSHELNPEARQGLYKLKAYI-GERMISNGFEVKNYVLPKFDVTIKQPETQSIGDNE 241

  Fly   234 IRATIKARYTFKKPVKGHV-VATIEGSSTEQSLPIDGEVNV--------------EFPISATA-- 281
            |:..:..:||:.:|:.|:. |.....|....|:|   ||::              .|..:.:|
Zfish   242 IKIEVCGKYTYGQPLPGNAWVEVCRDSFKYVSIP---EVHLCLNKTAQMNELGCASFIFNTSAFL 303

  Fly   282 --------KRLLKITAIVTEELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVRN 338
                    :..|.:...||||.|||....:..:::.....|:.....|..:..|...|.|..|.:
Zfish   304 NSTFENDLQNSLLVNTNVTEEGTDIVMTKSETISLTYELGKVTFAELPDLFEHGSIIEGKIKVAH 368

  Fly   339 LDGSPVMDSSKMVNFNVLCCQVSKNFSASLQNSIATEHIMLPETCQSCLVTSTFDTAE------- 396
            .:|:||.:.|       :.....:::|:.|..::.|:        ::.|...:|:||.
Zfish   369 FNGTPVYNKS-------VYLLEGRSWSSQLLLNLTTD--------RNGLAVFSFNTASLPSSDLH 418

  Fly   397 ------NIERYIYKL--------NKPLMIAINTKKPQLRKLLKINI---------ISDTYLPYF- 437
                  :...|.||.        ...|:.......|.|.:|:..||         |:.|...||
Zfish   419 LMASLTSEVHYGYKTPYFTADEKTVRLLQPATPYSPTLSELIIENIEQPLKCDTEITATVKYYFV 483

  Fly   438 -----------ILTVVARGNIVLSLFQEMKEKKKSQEI-----EFEPTFA--LVPQATIFVHYII 484
                       :..|::||.|:...:::::.|..|..:     .|:.:..  :.|...|..:.::
Zfish   484 GETVKDFNTDIVYMVLSRGVIIHHGYEKVEVKSSSNGVASGTMSFKLSVGADVAPVVQILAYCVL 548

  Fly   485 DG-VLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSGN 547
            .. ::::..:.:|:|:.|.|.:.: .:..:|:|.::.:|::.....|..||..||||||:|.||.
Zfish   549 PSEIVIAGSRKLDVEKCFRNKVSLQFSPAKAVPGEKNTLQLSAQSGSLCGLSAVDQSVLILESGK 613

  Fly   548 DLNRDLILNNLAT-------YS---------------------------------TDLVI----- 567
            .||.|.|.|.|..       ||                                 |:|::
Zfish   614 RLNADKIFNLLPVQYMSDYLYSVEDEQECLHVRSRRAVHTDSAYETLKSVGLKMATNLIVREPQC 678

  Fly   568 LTNANINIYRSSG-GCYTNPGYTNCTGSLIGRTMFKNEPTKNSGPVPIVGSTRAQASLPPVRKLF 631
            ||...:|.:||.| ..|:.........:....:...|.|...                  :|.:|
Zfish   679 LTYRGLNYHRSFGESDYSEDFVVKMAMNYEEDSFAVNSPDAT------------------IRTVF 725

  Fly   632 PETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQPFFITTNL 696
            ||||:: .:.:||.:|...:..|||||:|:|.:..|.|| .:||.:. .|:::.||||||:..:|
Zfish   726 PETWIW-QLAEVGDSGSAEVPVTVPDTITTWEMDAFCLS-STGLGLA-PPAQLTVFQPFFLELSL 787

  Fly   697 PYSVKRGEVIAIPVIVFNYLGMDVKAKV---------LMDNSDGQYEFIETTNKNVSQYLRGVRR 752
            |||:.|||:..:...|||||...:..||         |..:||.||          |..|....|
Zfish   788 PYSIIRGEIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQY----------SSCLCANGR 842

  Fly   753 KKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKYAG----------------DRLHQILKVEA 801
            :...||           :.|...|:..:.::|.::.:.                |.:.:.|:|:|
Zfish   843 QTFKWI-----------LTPSVFGVVNITVSAEAEASQTLCDNEIVSVPERGRIDTVTRSLRVQA 896

  Fly   802 DGVQKYVNKAVLINVQRLNRRSLAPPEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLV 866
            :||:|....:.|:..|    .|....|.|:.:  ..:||:||......|.|......|::|..|:
Zfish   897 EGVEKIKIYSWLLCPQ----GSRVSDEVTLTL--PSDVIKGSVRSSVSVLGDILGRALQNLHGLL 955

  Fly   867 HLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQH 931
            .:|.||||||:....|:|..|.||:...:....|..||..::::|||.:|||:.:|||:|.:|..
Zfish   956 KMPYGCGEQNIAVLSPNIYILQYLENTKQLTSAIREKASGFLKSGYQRQLNYRHHDGSYSTFGNG 1020

  Fly   932 DALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSH-----GS 991
            :  |:|||||:|:|||.:|.:||.:|..::.:..|:|:||:.:||.|.:.|. :.||.     ..
Zfish  1021 E--GNTWLTAFVLRSFDKAQRYIFVDPQIIQSAKDWLISRRDSDGCFIQQGR-LFNSRMKGGVND 1082

  Fly   992 PLALTSFVLLTFFENEEYMPKYKHVIDR---AVEFVVTEVHQSNEPYDLAIAALALSLARNRNA- 1052
            .:.:|:::..:..|.|  .|....|:.:   .:.||:.:|..:   |..|:.|...||||:.|.
Zfish  1083 KVTMTAYITASLLELE--TPVTNPVVTKGLSCLRFVIEDVKNT---YTTALLAYTFSLARDTNTR 1142

  Fly  1053 YKVLDKLDKLATRRGDHKWWTGS---DKCKSSEVETTSYVLLALLEHNISDE--------PKPIV 1106
            .::.:||:.||...|....|:.|   |...|.:||.:||||||:|   .:|.        ...||
Zfish  1143 QQLFNKLENLAISDGPLVHWSQSASADDSDSLDVEISSYVLLAVL---TADSLTTADLGFANRIV 1204

  Fly  1107 DWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQ 1171
            .||:.::|:.|||.|:|||||.:.||:.|..:..:|..:..:...... |.:|..|.::|:...|
Zfish  1205 SWLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSSTVTVQSAG-DSQHFDVNQDNKLLYQ 1268

  Fly  1172 THQLPENTNEVKLLAKGQGRAQVQLTYRYNVATKEARPSFKLTTTVKKSHKGRLILGICGTYTPI 1236
            ..||.....:..:..||.....||:...||:.|..  |:.| |.:|:.|     :.|.|     :
Zfish  1269 EKQLANVPGKYSIEVKGSACVSVQIPLFYNIPTPP--PTIK-TLSVEAS-----VTGDC-----L 1320

  Fly  1237 AASERN-------------KTTNMALMQVQLPSGYVCDIEPFA---DIEAISDVKRVETKNEDTE 1285
            |::.:|             ..|||.::.::|.||:..|....|   .:.|:. |:||:  :||..
Zfish  1321 ASTAKNLMLNFTIKYSGTQTRTNMVIVDIKLLSGFTADTSMLAIPPHMYALL-VERVD--SEDDH 1382

  Fly  1286 VHIYFEKLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEFY 1335
            :.:|.:::.....:..|::......|.:|:|:.:::||||.|...:...|
Zfish  1383 IMVYLKEVPKNSPQLYTIQMKQAFPVRSLRPAVIKVYDYYQTSDQSETLY 1432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	318/1250 (25%)
		A2M_2	859..1135	CDD:239227	104/295 (35%)
		A2M_recep	1243..1336	CDD:462226	25/96 (26%)
a2m2a	XP_001921519.4	YfaS	<127..1387	CDD:441940	345/1364 (25%)
		A2M	728..816	CDD:459711	37/90 (41%)
		A2M_2	947..1233	CDD:239227	104/296 (35%)