Protein Alignment CG7653 and AAP1

DIOPT Version :10

• Sequence 1: NP_001356886.1
• Gene: CG7653 / 34935
• FlyBaseID: FBgn0028935
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 708
• Identity: 180/708 - (25%)
• Similarity: 295/708 - (41%)
• Gaps: 142/708 - (20%)

  Fly    44 LPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHA-QKTTNQVVLHVGRVSIESKKITLFGETS 107
            ||..|.|.||||.|..:..:   .::.|.:||.:.. ..:.|.|.::...:...|.:|.
Yeast     6 LPNNVTPLHYDITLEPNFRA---FTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIE------ 61

  Fly   108 NYRLRSVRFN---NDRKYMVV----TFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKT 165
              .:.::..|   |.:|..:|    ||..   :|.|..|.:.|...:. ||..|::...|.:..|
Yeast    62 --GVNAIEVNKNENQQKATLVFPNGTFEN---LGPSAKLEIIFSGILN-DQMAGFYRAKYTDKVT 120

  Fly   166 SEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNREIQD-YVW 229
            .|..:.:.:.......|...|.||||:|||||.||:..........||.|:    |..|:: ..:
Yeast   121 GETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVR----NETIKEGKKY 181

  Fly   230 SVHEVTPTIPTHLLAFSV--------NNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAPQ 286
            :....||.:.|:|:||.|        |||..         ||  |..:...|.:...|||.:|.:
Yeast   182 TTFNTTPKMSTYLVAFIVADLRYVESNNFRI---------PV--RVYSTPGDEKFGQFAANLAAR 235

  Fly   287 ILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTL-ELIA 350
            .|.|.:....:..||.|:|.:.|.:|...||||:|||.||...|||..:. .|.:::|.: |:|.
Yeast   236 TLRFFEDTFNIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIEN-SSLDRIQRVAEVIQ 299

  Fly   351 HEMAHMWFDNLLGMDSYSDLWLTEGLAGY---------------FKSLAVDHLQSKMGRRILLRY 400
            ||:||.||.||:.||.:..|||.||.|.:               ::....|:||    |.:.|..
Yeast   300 HELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQ----RALNLDS 360

  Fly   401 RESSMMYESQVGGISLVPLSSNASLNA--ETQLYQKATSLTSMLIGFLGNETFYDGLQRHMWQNS 463
            ..||...|        ||:::...:|.  :...|.|.:||..|:..:||.|||..|:.:::.:..
Yeast   361 LRSSHPIE--------VPVNNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFK 417

  Fly   464 FGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEV------FLKQG 522
            :|::.....|.:|..||.:        ||.|:|:.||.:.|:|:::|..:.:::      :|..|
Yeast   418 YGNAKTGDLWDALADASGK--------DVCSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTG 474

  Fly   523 HALNRSSSHLWWIPLTYLIEGG---SLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVGY 584
            .......:.::.|.|......|   :|..|.|...:...|....|:|.            ...|.
Yeast   475 DVKEEEDTTIYPILLALKDSTGIDNTLVLNEKSATFELKNEEFFKING------------DQSGI 527

  Fly   585 YRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEP 649
            :..:|.:..|..|:    .....::|.:|..:|:|...|......:.:..||::....:||
Yeast   528 FITSYSDERWAKLS----KQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNED---- 584

  Fly   650 LMAFVVGWTNGFWGISTESSFNIAKWLGIAAKWYAEFISYTFDKFVVQDPNQNLNSLD 707
              :||| |......:|           .:.:.|             |.:|...||:||
Yeast   585 --SFVV-WEQIINSLS-----------ALKSTW-------------VFEPEDILNALD 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	135/482 (28%)
		ERAP1_C	574..>652	CDD:463368	13/77 (17%)
		dnaA	630..>701	CDD:455861	12/70 (17%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	136/484 (28%)
		ERAP1_C	517..833	CDD:463368	27/146 (18%)