DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7653 and Anpep

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_112274.1	Gene:	Anpep / 81641	RGDID:	2991	Length:	965	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	208/755 - (27%)
Similarity:	342/755 - (45%)	Gaps:	114/755 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YDEPRLPAKVKPFHYDIRLLTHLESSAN--HSYTGIVKISIHAQKTTNQVVLHVGRVSIESK--- 98
            :::.|||..:.|..|.:.|..:|..:..  :.:.|...:.....:|||.:::|..:::..:|
  Rat    71 WNQYRLPKTLIPDSYQVTLRPYLTPNEQGLYIFKGSSTVRFTCNETTNVIIIHSKKLNYTNKGNH 135

  Fly    99 KITL--FGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYI 161
            ::.|  .|:|....:.:.......:|:||....||:.|..|.:..||...:. |...|::...|:
  Rat   136 RVALRALGDTPAPNIDTTELVERTEYLVVHLQGSLVKGHQYEMDSEFQGELA-DDLAGFYRSEYM 199

  Fly   162 NWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLP--NREI 224
            .....:.:  :.:.......|.:.|.||||::||:||:|:.|.....:..||     ||  :|.:
  Rat   200 EGGNKKVV--ATTQMQAADARKSFPCFDEPAMKASFNITLIHPNNLTALSNM-----LPKDSRTL 257

  Fly   225 Q-DYVWSVHEV--TPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQ--SADVRATSFAAQMA 284
            | |..|:|.|.  ||.:.|:|||:.|:.|  :|.:|.|.:.|:.|..|:  :.|.....:|.|:.
  Rat   258 QEDPSWNVTEFHPTPKMSTYLLAYIVSEF--KYVEAVSPNRVQIRIWARPSAIDEGHGDYALQVT 320

  Fly   285 PQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLELI 349
            ..||.|..:....|.||||.||:.:.||...||||:|||.||...|:..........|.:.:.:|
  Rat   321 GPILNFFAQHYNTAYPLEKSDQIALPDFNAGAMENWGLVTYRESALVFDPQSSSISNKERVVTVI 385

  Fly   350 AHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYESQVGGI 414
            |||:||.||.||:.:|.::||||.||.|.|.:.|..|:.:.....:.|:...:   :|  :|..:
  Rat   386 AHELAHQWFGNLVTVDWWNDLWLNEGFASYVEFLGADYAEPTWNLKDLIVLND---VY--RVMAV 445

  Fly   415 SLV----PLSSNAS-LNAETQL--------YQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGS 466
            ..:    ||||.|: :|...|:        |.|..|:..||..||..:.|..||..::....:.:
  Rat   446 DALASSHPLSSPANEVNTPAQISELFDSITYSKGASVLRMLSSFLTEDLFKKGLSSYLHTFQYSN 510

  Fly   467 STPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL------ 525
            :.....|..||.|.:.:........|.:|||.|.:|.|:|::||..:..|::  |.|.|
  Rat   511 TIYLDLWEHLQQAVDSQTAIKLPASVSTIMDRWILQMGFPVITVNTSTGEIY--QEHFLLDPTSK 573

  Fly   526 -NRSS--SHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVGYYRV 587
             .|.|  ::||.:|:.||..|      .:...||....:. ........|:|:|||:...|||:|
  Rat   574 PTRPSDFNYLWIVPIPYLKNG------KEDHYWLETEKNQ-SAEFQTSSNEWLLLNINVTGYYQV 631

  Fly   588 NYDELTWQLLATTLFNDFRSINVLNRAQIV------------------SDVLFLWNQ-DLLAWST 633
            ||||..|:.:...|..|...|.|:|||||:                  |:.|||.:: :.:.|..
  Rat   632 NYDENNWRKIQNQLQTDLSVIPVINRAQIIHDSFNLASAGKLSITLPLSNTLFLASETEYMPWEA 696

  Fly   634 ALNVLKY---IIDEDE------------YEPLMAFVVGWTNGFW---------------GISTES 668
            ||:.|.|   :.|..|            ..||.|:....||. |               .|||..
  Rat   697 ALSSLNYFKLMFDRSEVYGPMKRYLKKQVTPLFAYFKIKTNN-WLDRPPTLMEQYNEINAISTAC 760

  Fly   669 SFNIAKWLGIAAKWYAEFISYTFDKFVVQDPNQNLNSLDY 708
            |..:.:...:....|:::::.:.:..:    :.||.|..|
  Rat   761 SSGLEECRDLVVGLYSQWMNNSDNNPI----HPNLRSTVY 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	135/474 (28%)
		ERAP1_C	574..>652	CDD:338125	35/111 (32%)
		dnaA	630..>701	CDD:234667	18/100 (18%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..68
		Metalloprotease	69..965		208/755 (28%)
		Peptidase_M1	75..479	CDD:279741	122/418 (29%)
		M1_APN_2	84..550	CDD:189008	138/480 (29%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		2/3 (67%)
		ERAP1_C	619..942	CDD:288671	47/183 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950