DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and Erap1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	651	Identity:	167/651 - (25%)
Similarity:	310/651 - (47%)	Gaps:	65/651 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YDEPRLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITL- 102
            ::..|||..:.|.|||:.:..:|.:.   ::.|..::.|.|.:.|:.:::|...:.|  .|.||
Mouse    38 WNNMRLPEYMTPIHYDLMIHANLSTL---TFWGKTEVEIIASRPTSTIIMHSHHLQI--SKATLR 97

  Fly   103 --FGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKT 165
              .||..:.....|......:.:.:...|.||.|..|.:.:::...:: :...|::...|...:.
Mouse    98 RGAGEMLSEEPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLS-ESFHGFYKSTYRTQEG 161

  Fly   166 SEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNRE--IQDYV 228
            ..:| .:.:.|.....|...|.||||:|||:|::.:....|..:..||.:...:...|  |:|:
Mouse   162 EMRI-LAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVNVAEGLIEDH- 224

  Fly   229 WSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAPQILEFLDR 293
               .::|..:.|:|:||.:::|  :.....:.|.|:....|....:....:|...|..:|||.:.
Mouse   225 ---FDITVKMSTYLVAFIISDF--KSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEFYED 284

  Fly   294 VLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWF 358
            ...:..||.|.|...:.||.:.||||:||..||...||..::...:..||....:::||:||.||
Mouse   285 YFNIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHELAHQWF 349

  Fly   359 DNLLGMDSYSDLWLTEGLAGY--FKSLAVDHLQSKMGRRILLRYRESSMMYESQVGGI-SLVPLS 420
            .||:.|:.::||||.||.|.:  |.|:.|.|.:.|:.     .|.........:|..: |..|:|
Mouse   350 GNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVE-----DYFFGKCFNAMEVDALNSSHPVS 409

  Fly   421 SNASLNAETQ------LYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSLQ-- 477
            :.....|:.:      .|:|...:.:||..:|..:||..|:.:::.:.|:.::..:..|.|:.
Mouse   410 TPVENPAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHI 474

  Fly   478 ------------LASEREATFDKTW-----DVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL 525
                        .:..:.::....|     |||::|:|||:|.|:||:|:..:|..|.:||.|.:
Mouse   475 CPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPLITITVSGRNVHMKQEHYM 539

  Fly   526 NRS-----SSHLWWIPLTYLI-EGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVGY 584
            ..|     :.:||.:|||::. :..|:.:.|     |...:..:.|.:.|   |||..|:...||
Mouse   540 KGSERFPETGYLWHVPLTFITSKSDSVQRFL-----LKTKTDVLILPEAV---QWIKFNVGMNGY 596

  Fly   585 YRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEP 649
            |.|:|.:..|..|:..|.....:|:..:||.::::...|.:.:.|:...||::..|:.:|.|..|
Mouse   597 YIVHYADDGWASLSGLLKEAHTTISSNDRASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIMP 661

  Fly   650 L 650
            :
Mouse   662 I 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	117/480 (24%)
		ERAP1_C	574..>652	CDD:338125	22/77 (29%)
		dnaA	630..>701	CDD:234667	6/21 (29%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	118/482 (24%)
		Substrate binding. /evidence=ECO:0000250	306..310		2/3 (67%)
		ERAP1_C	586..905	CDD:403137	22/77 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845840
Domainoid	1	1.000	46	1.000	Domainoid score	I12048
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950