DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	740	Identity:	200/740 - (27%)
Similarity:	337/740 - (45%)	Gaps:	113/740 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YDEPRLPAKVKPFHYDIRLLTHLE----SSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKK 99
            :|..|||..:.|.|||:.|...|:    |..|.::||.|.|::.....:::::||  ...:..|:
Mouse    90 WDHLRLPPWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLH--SFLLNYKQ 152

  Fly   100 ITLFG----ETSN-----YRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGY 155
            :.::|    :|.|     .::..|.|..|.:::|:...|||..|..|.||..|...:.....:|.
Mouse   153 VEVWGPLAQDTRNATVGRVQVEKVWFAPDMQFVVLDLGQSLEPGSRYELSFHFSGQVLQVGLEGL 217

  Fly   156 FIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLP 220
            |:..|.:  ..|......:.....:.|:..|.||||:||||||:|:.||..:.:..||.......
Mouse   218 FLNLYHD--EDELRALVATQMEPTFARHVFPCFDEPALKATFNITVIHHPGYAALSNMPQLGQSE 280

  Fly   221 NREIQDYVWSV--HEVTPTIPTHLLAFSVNNFN--CRYSQAASLSPVRFRTCAQSADVRA--TSF 279
            ..::....|:|  ...||.:||:|:|..|.:.:  .|..:...:     |..|:..|:.:  ..|
Mouse   281 RIDVNGSRWTVTTFHTTPRMPTYLVALVVCDLDHISRTERGKEI-----RVWARKDDIASGYLDF 340

  Fly   280 AAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQ 344
            ||.:...|..||:.:..::..|.|.|.:.:..|.:.||||:||:::....|||..:..:::::..
Mouse   341 AANITGPIFSFLEDLFNISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLEPEDELTEKRAM 405

  Fly   345 TLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYR-------E 402
            .|.:||||:.|.||.||:.|..::::||.||.|.||:....::...|:...::..:.       |
Mouse   406 ILSIIAHEVGHQWFGNLVTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIFFFTVLHGILGE 470

  Fly   403 SSMMYESQVGGISLVPLSSNASLNA--ETQLYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFG 465
            ...: ||:....::...:..:.:|.  :...|:|...:..||..||....|.:.|:.::...|:.
Mouse   471 DHAL-ESRAVSTAVENFTETSEINRLFDLYTYKKGACMAWMLASFLSPHLFINALKSYLETFSYS 534

  Fly   466 SSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQ-----GHAL 525
            ::..|..||.:|:|...:........||.|||:||.:.|:|::||  |.|...:||     ....
Mouse   535 NAEQDDLWRHIQMAIGEQNVTHLPATVKGIMDSWTHRGGFPIITV--NVSTGVVKQEPFYLDKVE 597

  Fly   526 NR---SSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNS---HGIKLNDIVPRNQWILLNLQAVGY 584
            |:   |.:..|.:|:.::..|..     :|..||..::   .|:||:|  ..:.|::||....||
Mouse   598 NQTLLSHNSTWIVPIFWMKNGIP-----QPLVWLDKSNMMFPGMKLSD--SDSDWVILNFNVTGY 655

  Fly   585 YRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDE--- 646
            ||||||||.|:.|:..|..|.::|.|:||.|:|||...|...:.:...|||::.|||.:|||
Mouse   656 YRVNYDELGWKKLSEQLEKDPKAIPVINRLQLVSDAFALTKNNYIEIETALDLTKYIAEEDEILV 720

  Fly   647 ----------------------YEPLMAFVVGWTNGFWG--------------------ISTESS 669
                                  |..|..:::...|..|.                    .|.|..
Mouse   721 WFEVLLNLINREVIYDVNNYALYPLLKKYLLKRFNSIWNTYSAIIRENVASLQDNYLSLFSLERI 785

  Fly   670 FNIAKWLGIA----------AKWYA 684
            |..|.|||:.          .||.|
Mouse   786 FETACWLGLEDCLQLSRELFKKWTA 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	124/475 (26%)
		ERAP1_C	574..>652	CDD:338125	37/102 (36%)
		dnaA	630..>701	CDD:234667	23/110 (21%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	110/419 (26%)
		M1_APN_2	102..575	CDD:189008	127/482 (26%)
		Substrate binding. /evidence=ECO:0000250	376..380		2/3 (67%)
		ERAP1_C	646..964	CDD:288671	48/165 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850