DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and ERAP2

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	774	Identity:	191/774 - (24%)
Similarity:	324/774 - (41%)	Gaps:	164/774 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LYGLLLLLCLCQ------------------VACSAKTQLYDEPRLPAKVKPFHYDIRL---LTHL 61
            |..:|..:|:|.                  ||.:.:...:.|.|||:.|.|.|||:.:   ||.|
Human    25 LTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSL 89

  Fly    62 ESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLFGETSNYRLRSVRFNNDRKYM--- 123
            :..|:.      ||.:.....|..::||       ||.:    |.:|..|:|   ..|.:||
Human    90 DFVASE------KIEVLVSNATQFIILH-------SKDL----EITNATLQS---EEDSRYMKPG 134

  Fly   124 ----VVTF----------NQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVS 174
                |:::          .:.|.....|.::::|...:. |..:|::...|.......:| .:|:
Human   135 KELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG-DGFEGFYKSTYRTLGGETRI-LAVT 197

  Fly   175 HFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNM-KVQAV-LPNREIQDYVWSVHEVTPT 237
            .|.....|...|.||||..||.|::.:....|..:..|| ||:.: |....::|:    .|.|..
Human   198 DFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDH----FETTVK 258

  Fly   238 IPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLE 302
            :.|:|:|:.|.:|:.  ....:.|.|:....|.......|.:|.|.:.::|:|.::...:..||.
Human   259 MSTYLVAYIVCDFHS--LSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLS 321

  Fly   303 KIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSY 367
            |:|.:.:.||...||||:||:.||...||.......:.:||....:||||:||.||.||:.|:.:
Human   322 KLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWW 386

  Fly   368 SDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYESQVGGISLVPLSSNASLNAE---- 428
            :|:||.||.|.|.:.:||:           ..|.|  :.::.....:....::.: |||:.
Human   387 NDIWLKEGFAKYMELIAVN-----------ATYPE--LQFDDYFLNVCFEVITKD-SLNSSRPIS 437

  Fly   429 ------TQL--------YQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSL--- 476
                  ||:        |.|...:.:||..|||.|.|..|:.:::.:.|:.::..|..|.||
Human   438 KPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNS 502

  Fly   477 ----------------QLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL 525
                            ::.|...|...:..:||.:|.|||:|.|.||:.|.::|..:.|:|...|
Human   503 CLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFL 567

  Fly   526 N-----------RSSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNL 579
            .           ....:||.|||||    .:.|.|:..:..|...:..:   |:..:..|:..|:
Human   568 QGVFQEDPEWRALQERYLWHIPLTY----STSSSNVIHRHILKSKTDTL---DLPEKTSWVKFNV 625

  Fly   580 QAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDE 644
            .:.|||.|:|:...|..|.|.|..:...:...:|..::.||..|.....|....||::..|:..|
Human   626 DSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHE 690

  Fly   645 DEYEPLMAFVVGWTNGFWGISTESSFNIAKWLGIAAKWYAEFISYTFDKFVVQDPNQNL 703
            .....|:.          |:|                 |.|...:..|:..:.|.::||
Human   691 TSSPALLE----------GLS-----------------YLESFYHMMDRRNISDISENL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	128/506 (25%)
		ERAP1_C	574..>652	CDD:338125	21/77 (27%)
		dnaA	630..>701	CDD:234667	11/70 (16%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	113/431 (26%)
		M1_APN_2	76..548	CDD:189008	132/513 (26%)
		Substrate binding	334..338		2/3 (67%)
		ERAP1_C	621..938	CDD:288671	28/129 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950