Protein Alignment CG7653 and ERAP2

DIOPT Version :10

• Sequence 1: NP_001356886.1
• Gene: CG7653 / 34935
• FlyBaseID: FBgn0028935
• Length: 710
• Species: Drosophila melanogaster
• Sequence 2: NP_071745.1
• Gene: ERAP2 / 64167
• HGNCID: 29499
• Length: 960
• Species: Homo sapiens
• Alignment Length: 774
• Identity: 191/774 - (24%)
• Similarity: 324/774 - (41%)
• Gaps: 164/774 - (21%)

  Fly    18 LYGLLLLLCLCQ------------------VACSAKTQLYDEPRLPAKVKPFHYDIRL---LTHL 61
            |..:|..:|:|.                  ||.:.:...:.|.|||:.|.|.|||:.:   ||.|
Human    25 LTAILPQICICSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSL 89

  Fly    62 ESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLFGETSNYRLRSVRFNNDRKYM--- 123
            :..|:.      ||.:.....|..::||       ||.:    |.:|..|:|   ..|.:||
Human    90 DFVASE------KIEVLVSNATQFIILH-------SKDL----EITNATLQS---EEDSRYMKPG 134

  Fly   124 ----VVTF----------NQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVS 174
                |:::          .:.|.....|.::::|...:. |..:|::...|.......:| .:|:
Human   135 KELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG-DGFEGFYKSTYRTLGGETRI-LAVT 197

  Fly   175 HFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNM-KVQAV-LPNREIQDYVWSVHEVTPT 237
            .|.....|...|.||||..||.|::.:....|..:..|| ||:.: |....::|:    .|.|..
Human   198 DFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIELEGGLLEDH----FETTVK 258

  Fly   238 IPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLE 302
            :.|:|:|:.|.:|:.  ....:.|.|:....|.......|.:|.|.:.::|:|.::...:..||.
Human   259 MSTYLVAYIVCDFHS--LSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLS 321

  Fly   303 KIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSY 367
            |:|.:.:.||...||||:||:.||...||.......:.:||....:||||:||.||.||:.|:.:
Human   322 KLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWW 386

  Fly   368 SDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYESQVGGISLVPLSSNASLNAE---- 428
            :|:||.||.|.|.:.:||:           ..|.|  :.::.....:....::.: |||:.
Human   387 NDIWLKEGFAKYMELIAVN-----------ATYPE--LQFDDYFLNVCFEVITKD-SLNSSRPIS 437

  Fly   429 ------TQL--------YQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSL--- 476
                  ||:        |.|...:.:||..|||.|.|..|:.:::.:.|:.::..|..|.||
Human   438 KPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNS 502

  Fly   477 ----------------QLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL 525
                            ::.|...|...:..:||.:|.|||:|.|.||:.|.::|..:.|:|...|
Human   503 CLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFL 567

  Fly   526 N-----------RSSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNL 579
            .           ....:||.|||||    .:.|.|:..:..|...:..:   |:..:..|:..|:
Human   568 QGVFQEDPEWRALQERYLWHIPLTY----STSSSNVIHRHILKSKTDTL---DLPEKTSWVKFNV 625

  Fly   580 QAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDE 644
            .:.|||.|:|:...|..|.|.|..:...:...:|..::.||..|.....|....||::..|:..|
Human   626 DSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHE 690

  Fly   645 DEYEPLMAFVVGWTNGFWGISTESSFNIAKWLGIAAKWYAEFISYTFDKFVVQDPNQNL 703
            .....|:.          |:|                 |.|...:..|:..:.|.::||
Human   691 TSSPALLE----------GLS-----------------YLESFYHMMDRRNISDISENL 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	128/506 (25%)
		ERAP1_C	574..>652	CDD:463368	21/77 (27%)
		dnaA	630..>701	CDD:455861	11/70 (16%)
ERAP2	NP_071745.1	M1_APN-Q_like	76..543	CDD:341064	129/508 (25%)
		ERAP1_C	620..938	CDD:463368	29/130 (22%)