DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and Enpep

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	637	Identity:	181/637 - (28%)
Similarity:	301/637 - (47%)	Gaps:	68/637 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLFGET- 106
            |||..::|.|||:.:...:|..   .|||||.||::..|.|..:.||     |...:||...|.
  Rat    84 RLPDFIQPVHYDLEVKVLMEED---RYTGIVSISVNLSKDTRDLWLH-----IRETRITKLPELR 140

  Fly   107 ----SNYRLRSVRFNNDRKYMVVTFNQSL--LMGKS-YVLSVEFGRPMTMDQRDGYFIRHYINWK 164
                ....:|.......::|:|:...:.|  ..|.| |.|::||...:     :|..:..|....
  Rat   141 RPSGEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWL-----NGSLVGFYRTTY 200

  Fly   165 TSEKIWYSVSHFNR--NWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNREIQDY 227
            |.:....|::..:.  ...|.:.|.||||:.|||:|:::.|.|.:.:..||.|:    ..|..|.
  Rat   201 TEDGQTKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVE----KEETLDN 261

  Fly   228 VWSVHEVTPTIP--THLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAAQMAPQILEF 290
            .|.......::|  |:|:.|:|:.|..  .|..|.|........|....:...:||.:...:.:|
  Rat   262 DWKKTTFMKSVPMSTYLVCFAVHQFTS--IQRTSRSGKPLTVYVQPNQKQTAEYAANITKAVFDF 324

  Fly   291 LDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAH 355
            .:....:...|.|:|::.:.||.|.||||:|||.||..:||.......|..:.:...::|||:.|
  Rat   325 FEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRVASVVAHELVH 389

  Fly   356 MWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQS--KMGRRILLR-----YRESSMMYESQVGG 413
            .||.|::.||.:.||||.||.|.:|:.|.|:|.::  :|..::||.     ..:.|:|....|
  Rat   390 QWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHPV-- 452

  Fly   414 ISLVPLSSNASLNA--ETQLYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSL 476
              :|.:|:.|.:.:  :...|.|..|:..||..::..|.|..|.|.::....|.::....||.||
  Rat   453 --VVTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFWDSL 515

  Fly   477 QLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHALNRSS---------SHL 532
            :.||.:        .||.:|||||.|.|||:|||  :|.:...::...|:..:         .:.
  Rat   516 EKASNQ--------PVKEVMDTWTSQMGYPVVTV--SGKQNVTQKRFLLDYKADPSQPPSALGYT 570

  Fly   533 WWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLL 597
            |.||:.:...|.|   |:  ..:...|..||.||..:..:.::.:|...:|:|||||:..||..:
  Rat   571 WNIPIKWTENGNS---NI--TVYYRSNREGITLNANLSGDGFLKINPDHIGFYRVNYEAETWDWI 630

  Fly   598 ATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEP 649
            |.||.::..:.:..:|:..:.|...|....||.:..|||:.:|:..|.::.|
  Rat   631 AETLSSNHMNFSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLP 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	132/468 (28%)
		ERAP1_C	574..>652	CDD:338125	23/76 (30%)
		dnaA	630..>701	CDD:234667	6/20 (30%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77
		Peptidase_M1	84..474	CDD:279741	116/412 (28%)
		M1_APN_2	92..537	CDD:189008	136/475 (29%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		2/3 (67%)
		ERAP1_C	608..922	CDD:288671	23/75 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020