DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7653 and trhde.2

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	696	Identity:	188/696 - (27%)
Similarity:	329/696 - (47%)	Gaps:	68/696 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITLFGETS 107
            ||||.::|.|||:||..|:|   |.|::|.|.|......:|..:|||..|:.::  |:.:|.::.
Zfish   109 RLPATLRPRHYDLRLTVHME---NFSFSGEVNIEFECVNSTKLIVLHSDRLELD--KVLVFSDSK 168

  Fly   108 NYRLRSV--RFNNDRKYM-VVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKTSEKI 169
            ......:  ||:...|.: |:..::.:...::|.:::.|...:..:.. |:|...|:  ...|:.
Zfish   169 KAGAMRIQRRFHYQPKQVYVIALHREMKPLRTYKINITFTAHIEHELL-GFFRSSYM--LNGERR 230

  Fly   170 WYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNREIQDYVWSVHEV 234
            :.:|:.|:....|...|.||||..||||.|::.|...:||..||.|:|...:.:  .:|.:....
Zfish   231 FLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESSYQSLSNMPVEATTSDED--GWVTNHFSR 293

  Fly   235 TPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATS--FAAQMAPQILEFLDRVLQV 297
            ||.:.|:.||::|.||.  |.:|.:.:.|..|..|:...:::.|  :|.::..::|:|.....:|
Zfish   294 TPRMSTYYLAWAVCNFT--YKEAVADNGVLIRLYARPDAIQSGSGDYALRITKRLLQFYQDYFKV 356

  Fly   298 ALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLL 362
            ...|.|:|.|.|...|..||||:||.|:..:.:||..|......:::...::.||:.|.||.:|:
Zfish   357 KYSLPKLDLLAVPKHPYAAMENWGLSVFVEQKILLDPDVSSFSYQMELTMVVVHEICHQWFGDLV 421

  Fly   363 GMDSYSDLWLTEGLAGYFKSLAVDHLQSKMG---RRILLRYRESSMMYESQVGGISLVPLSSNAS 424
            ....:.|:||.||.|.||:.:..|.|..|..   :|.|.......|:.:   |..|..|:|....
Zfish   422 TPVWWEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQRFLTDVLHEVMLLD---GLASSHPISQQVF 483

  Fly   425 LNAETQ------LYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSLQLASERE 483
            ...:..      .|:|..:|..||...:|...|...|..::..:.:|::..|..|..|..|.:||
Zfish   484 EATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRALNDYLMTHMYGNAARDDLWNKLSEAMQRE 548

  Fly   484 ATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGS---EVFLKQGHALNRSSSHL-----------WW 534
            .   |..::..:||.||:|.|||:||:.:|.|   .:.:.|.|.:..:.:.:           |.
Zfish   549 G---KDINITQVMDRWTLQMGYPVVTISKNDSLDNSITISQEHFVYDTDAKIQNPELFNKSFQWQ 610

  Fly   535 IPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLLAT 599
            |||| |..|.:...:.:...|::..|...::..:|... |:|.|:...||:|||||...|:||..
Zfish   611 IPLT-LAVGNASHISTETIIWVTNKSEAHRVGHVVGET-WLLGNINQTGYFRVNYDLHNWKLLIQ 673

  Fly   600 TLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEPLMAFVVGWTNGFWGI 664
            .|..:...|:|.|||.::.||..|.....|..:..|.::.|:..|.|:.|            |..
Zfish   674 QLTRNPTIISVGNRAGLIDDVFNLARAGYLPQNVPLQMISYLSQETEFLP------------WHA 726

  Fly   665 STESSFNIAKWLGIAAKWYAEFISYT-FDKFVVQDPNQNLNSLDYP 709
            ::.:.:.:.|.|.       ..:.:: |..:|::......:.|.:|
Zfish   727 ASRALYQLDKLLD-------RTLDHSLFSDYVLRQVEPKYHKLGWP 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	126/461 (27%)
		ERAP1_C	574..>652	CDD:338125	28/77 (36%)
		dnaA	630..>701	CDD:234667	10/71 (14%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	114/405 (28%)
		M1_APN_2	118..568	CDD:189008	130/467 (28%)
		ERAP1_C	649..968	CDD:288671	34/136 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.040