DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7653 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	701	Identity:	189/701 - (26%)
Similarity:	322/701 - (45%)	Gaps:	92/701 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YDEPRLPAKVKPFHYDIRLLTHL--ESSANHSYTGIVKISIHAQKTTNQVVLHVGRV--SIESKK 99
            :|:.|||..:.|.:|:|.|...|  :....:.:||...::....|.|:.:::|...:  |:.::|
Zfish    65 WDKYRLPDTLLPEYYNITLWPRLTKDDLGMYIFTGKSGVAFLCVKETDLILIHSSNLNYSLTAEK 129

  Fly   100 ----ITLFGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHY 160
                :...|.|....:....|.:..::||:...::|.:||||.|..||...:. |...|::...|
Zfish   130 HHAELMGLGGTRAPVILKTWFQDQTEFMVIQLRENLQVGKSYWLYTEFQGELA-DDLGGFYRSEY 193

  Fly   161 INWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGN----------MKV 215
            :. ...||: .:.:.......|...|.|||||:||.|::|:.|.....:..|          ::.
Zfish   194 VE-NGVEKV-VATTQMQPTAARTAFPCFDEPSMKAVFHLTLIHPPGTVALANGMETGTENITIEN 256

  Fly   216 QAVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNF-NCRYSQAASLSPVRFRTCAQSADVRATSF 279
            |.||..|         .|.|..:.|:||||.::.| :.:....|:...||.....::.:.....:
Zfish   257 QQVLQTR---------FEPTEKMSTYLLAFVISEFPSIQSPLGANKILVRIWGRREAIENGEGDY 312

  Fly   280 AAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQ 344
            |..:...:|::|:.......||.|.||:.:.||...||||:|||.||...|.........::|..
Zfish   313 ALNVTFPVLKYLESYYNTTYPLSKSDQIALPDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEG 377

  Fly   345 TLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYES 409
            .:.:|:||:|||||.||:.|..::||||.||.|.|...||.|:.:.....:.|:..::   :|.:
Zfish   378 VITVISHELAHMWFGNLVTMRWWNDLWLNEGFASYVSYLAADYAEPTWNIKELMVLQQ---VYRA 439

  Fly   410 QV--GGISLVPLSSNA-SLNAETQL--------YQKATSLTSMLIGFLGNETFYDGLQRHMWQNS 463
            ..  ..:|..||||.. ::|...|:        |.|..::..||..||....|..||..::.:::
Zfish   440 FTVDALVSSHPLSSREDAVNTPQQIEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQEHA 504

  Fly   464 FGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTV-IRNGSEVFLKQGHAL-- 525
            :.::.....|:.||..::.:........::.||:.|.:|:|:|:||: ...||   :.|.|.|
Zfish   505 YSNTVYTDLWKKLQEVADSDGNVHLPASIEEIMNRWILQAGFPVVTIDTHTGS---ISQQHFLID 566

  Fly   526 -----NRSS--SHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQAVG 583
                 |:.|  ::.|::|:|::..|.::.::     ||...|...:|  :.....|||.||...|
Zfish   567 PEAVVNKPSDYNYEWFVPITWMKNGRNMGQH-----WLLNKSTSYEL--MKTETNWILANLNVTG 624

  Fly   584 YYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYE 648
            |||||||...|:.|...|.:|.::|.||||.||:.|...|....:|..:.||...:|:.:|.||.
Zfish   625 YYRVNYDSQNWERLIKQLTSDHQAIPVLNRGQIIDDAFTLARAKILNITMALRTTQYLSNEKEYI 689

  Fly   649 PLMAFVVGWTNGFWGISTESSFNIAKWLGIAAKWYAEFISYTFDKFVVQDP 699
            |       |.:....:                    |:....||:..|:.|
Zfish   690 P-------WESAIRNL--------------------EYFFLMFDRTEVRGP 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	123/477 (26%)
		ERAP1_C	574..>652	CDD:338125	34/77 (44%)
		dnaA	630..>701	CDD:234667	13/70 (19%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	126/482 (26%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	40/126 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020