DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and ERAP1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	685	Identity:	174/685 - (25%)
Similarity:	312/685 - (45%)	Gaps:	80/685 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LYGLLLLLCLCQVACSAKTQL-----------YDEPRLPAKVKPFHYDIRLLTHLESSANHSYTG 71
            |..||.||.:...:....|:.           :::.|||..|.|.|||:.:..:|.:.   ::.|
Human    17 LSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTL---TFWG 78

  Fly    72 IVKISIHAQKTTNQVVLHVGRVSIESKKITL---FGETSNYRLRSVRFNNDRKYMVVTFNQSLLM 133
            ..|:.|.|.:.|:.::||...:.|  .:.||   .||..:.....|..:..::.:.:...:.||:
Human    79 TTKVEITASQPTSTIILHSHHLQI--SRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLV 141

  Fly   134 GKSYVLSVEFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFN 198
            |..|.:.:.:...:: :...|::...| ..|..|....:.:.|.....|...|.||||:.||:|:
Human   142 GLPYTVVIHYAGNLS-ETFHGFYKSTY-RTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFS 204

  Fly   199 VTMGHHKRFQSYGNMKVQAVLPNRE--IQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLS 261
            :.:....|..:..||.:...:...|  |:|:    .:||..:.|:|:||.:::|..  ....:.|
Human   205 IKIRREPRHLAISNMPLVKSVTVAEGLIEDH----FDVTVKMSTYLVAFIISDFES--VSKITKS 263

  Fly   262 PVRFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYR 326
            .|:....|....:....:|...|..:|||.:....:..||.|.|...:.||.:.||||:||..||
Human   264 GVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYR 328

  Fly   327 SKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGY--FKSLAVDHLQ 389
            ...||...:...:..||.....:|||:||.||.||:.|:.::||||.||.|.:  |.|::|.|.:
Human   329 ESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPE 393

  Fly   390 SKMGRRILLRYRESSMMYESQVGGI-SLVPLSSNASLNAETQ------LYQKATSLTSMLIGFLG 447
            .|:|     .|.........:|..: |..|:|:.....|:.:      .|.|...:.:||..:|.
Human   394 LKVG-----DYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLS 453

  Fly   448 NETFYDGLQRHMWQNSFGSSTPDLFWRSLQ--------------LASEREATFDKTW-----DVK 493
            .:.|..|:.:::.::|:.::..:..|.|:.              .:..:.::....|     |||
Human   454 ADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVK 518

  Fly   494 SIMDTWTMQSGYPLVTVIRNGSEVFLKQGHALNRS-----SSHLWWIPLTYLIEGGSLSKN--LK 551
            ::|:|||:|.|:||:|:...|..|.:||.|.:..|     :.:||.:|||::.....:...  ||
Human   519 TMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLK 583

  Fly   552 PKAWLSPNSHGIKLNDIVPRN-QWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQ 615
            .|..:.          |:|.. :||..|:...|||.|:|::..|..|...|.....:::..:||.
Human   584 TKTDVL----------ILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRAS 638

  Fly   616 IVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEPL 650
            ::::...|.:...|:...||::..|:..|.|..|:
Human   639 LINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPV 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	119/480 (25%)
		ERAP1_C	574..>652	CDD:338125	21/77 (27%)
		dnaA	630..>701	CDD:234667	6/21 (29%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	123/487 (25%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	21/77 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155387
Domainoid	1	1.000	45	1.000	Domainoid score	I12219
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950