DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and enpep

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001186660.1	Gene:	enpep / 504088	ZFINID:	ZDB-GENE-050309-218	Length:	951	Species:	Danio rerio

Alignment Length:	658	Identity:	173/658 - (26%)
Similarity:	299/658 - (45%)	Gaps:	107/658 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RLPAKVKPFHYDIRLLTHLESSANHS-YTGIVKISIHAQKTTNQVVLHVG----RVSIESKKITL 102
            |||..:.|||||:    |:|...|.. |||.|.:.:...:.:..:.||:.    .|....::.:.
Zfish    80 RLPDYILPFHYDL----HMEPDLNTDIYTGDVSVHLKLTQPSQHLWLHIRDTFVTVMPSLQRSSP 140

  Fly   103 FGETSNYRLRSVRFNNDRKYMVVTFNQSLLM---GKSYVLSVEFGRPMTMDQRDGYFIRHYINWK 164
            .|.|| .:|:.......::|:||...:.|.:   .:.|||::                 |:..|.
Zfish   141 SGVTS-VKLKQCFEYKPQEYVVVEAAEQLSVTGPDEHYVLTL-----------------HFQGWL 187

  Fly   165 TSEKIWYSVSHFNRNWI--------------RNTMPSFDEPSLKATFNVTMGHHKRFQSYGNM-- 213
            ....:.:..:.:..|.:              |.:.|.||||:.|||:.:::.|...:::..||
Zfish   188 NGSLVGFYRTTYQENGVTKKIAATDHEPTDARKSFPCFDEPNKKATYTISITHDSTYKALSNMPV 252

  Fly   214 -KVQAVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRAT 277
             |.:.:...:....::.||     .:.|:|:.|:|:.|:  :.:..|...:..|..||...:...
Zfish   253 EKTEKLSEQKTKTSFMKSV-----KMSTYLVCFAVHQFD--FVERTSKRGIPLRIYAQPLQISTA 310

  Fly   278 SFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEK 342
            ::||.:...|.::.:....:...::|:|::.:.||.|.||||:||:.||..:||..|....|..|
Zfish   311 AYAADVTQVIFDYFEEYFDMEYSIQKLDKIAIPDFGTGAMENWGLITYRETNLLFDEKESSSVNK 375

  Fly   343 LQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMY 407
            .:...:||||:.|.||.|::.||.:.||||.||.|.:|:.:.|:..:...|.|.::...:   :|
Zfish   376 QRVASVIAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEYIGVEEAEHDWGMRDVMLIND---VY 437

  Fly   408 ESQVGGISL------VPLSSNASLNA--ETQLYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSF 464
            ...|....|      |.:||.|.:.:  :...|.|..|:..||...||.|||.||.:|::....|
Zfish   438 PVMVDDALLSSHPIIVDVSSPAEITSVFDAISYNKGASILRMLEDLLGRETFRDGCRRYLKTYLF 502

  Fly   465 GSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL---N 526
            .::....||::  ||.|      ....|..||||||.|.|||::::....:|..|.|...|   |
Zfish   503 QNAKTSDFWKA--LADE------SGLPVADIMDTWTKQMGYPVLSLTNTDTEAKLTQTRFLLDPN 559

  Fly   527 RSSS-------HLWWIPL----------TYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQW 574
            ...|       :.|.||:          :::.|.|      :.:|.:|..||.        .|..
Zfish   560 ADPSQPTTPLGYKWTIPVKWKALDSTNNSFIFEKG------QTEAVISGYSHA--------TNGL 610

  Fly   575 ILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLK 639
            |.:|...:|:||||:.:..|..:|..|..|.:..:..:|:..:.|:..|...|::.:..|.|:.:
Zfish   611 IKVNKDHMGFYRVNHHDQMWSDIAEQLLMDHQVYDATDRSSYIDDIFALGRADMVDYGNAFNLTR 675

  Fly   640 YIIDEDEY 647
            |:.||.||
Zfish   676 YLADETEY 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	124/480 (26%)
		ERAP1_C	574..>652	CDD:338125	22/74 (30%)
		dnaA	630..>701	CDD:234667	7/18 (39%)
enpep	NP_001186660.1	Peptidase_M1	80..473	CDD:279741	106/424 (25%)
		M1_APN_2	89..536	CDD:189008	128/486 (26%)
		ERAP1_C	611..927	CDD:288671	22/73 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020