DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and CG46339

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	203/730 - (27%)
Similarity:	321/730 - (43%)	Gaps:	118/730 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PAKV----KPFHYDIRLLTHLESS-ANHSYTGIVKISIHAQKTTN--QVVLHVGRVSIESKKI-- 100
            |.|:    :|.||.:.:...:.:| :|.|.|  ::|.....|.|:  .:||.|..|||.:.::
  Fly   287 PLKLYEGWRPLHYSLLIEPSVATSISNGSLT--IEIERDVSKVTSWEPIVLDVHNVSISNVRVIR 349

  Fly   101 -TLFGETSNYRLRSVRFNN----DRKYMVVTFNQSLLMGKS--YVLSVEFGRPMTMDQRDGYFIR 158
             ...|.::....:.:.|::    |....|:..:::|.:...  .:||::|...:| |...|.:..
  Fly   350 ALADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVT-DTLQGIYKT 413

  Fly   159 HYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQ-SYGNMKVQAVLPNR 222
            .|.|..|..:.|...:.|:....|...|.||.|.:||.|::::....:|: :..||....  ..|
  Fly   414 SYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSG--SRR 476

  Fly   223 EIQDYVWSVHEVTPTIPTHLLAFSVNNF-NCRY-SQAASLSPVRFRTCAQSADVRATSFAAQMAP 285
            ..:.::....|.||.:||:|:||.|:|. :.|. ||.:.|:| |.....:...|..|.:|.:|..
  Fly   477 FRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTP-RVEIWTRPQFVGMTHYAYKMVR 540

  Fly   286 QILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPM--SKEKLQTLE- 347
            :.|.:.:....:...|.|||.:.|.||...||||:||:.:|...||:.||..:  |.|.:|.:.
  Fly   541 KFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAG 605

  Fly   348 LIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQ---SKMGRRILLRYRESSMMYES 409
            :||||:||.||.||:....:.||||.||.|.|....|::|..   ..|....:|.::| ||.:::
  Fly   606 IIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKE-SMEHDA 669

  Fly   410 Q--VGGISLVPLSSNASLNAETQL-YQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDL 471
            .  ...||....|:|........: |.|.|.|..||...:|:..|....:..:.:.::|:...|.
  Fly   670 DNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDD 734

  Fly   472 FWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQGHAL----NRSSSHL 532
            .|..|......:.|..|...||.|||:|..|.|||:|.|.|.|:::.|:|...|    |.:....
  Fly   735 LWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQST 799

  Fly   533 WWIPLTYLIEGGSLSK--NLKPKAWL----------------SPNSHGIKLNDIVPRNQWILLNL 579
            |:||:|:  |...|.|  |: |..|:                |.||..:           |.|||
  Fly   800 WFIPITF--ETDELRKGDNI-PTHWMRSEDEEELIVGNVFAHSSNSDNV-----------IYLNL 850

  Fly   580 QAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIID- 643
            ...||||||||..:|    ..|..:|.::..:.|||::.|.|.|...:.|.:...|..|..:.|
  Fly   851 NRQGYYRVNYDMTSW----LALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDA 911

  Fly   644 -EDEYEPLMAFVVGWTNGFWGISTESSFNIAKWLGIAAKWYAEFISY------------TFDKFV 695
             :||.                            |.||||....::.|            .|.||:
  Fly   912 VDDEL----------------------------LWIAAKPGLNYLIYNLKREPAYETFRAFMKFI 948

  Fly   696 VQDPNQNLNSLDYPD 710
            |: |..:...|..||
  Fly   949 VR-PAFDHYGLHEPD 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	133/471 (28%)
		ERAP1_C	574..>652	CDD:338125	27/79 (34%)
		dnaA	630..>701	CDD:234667	16/84 (19%)
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	116/408 (28%)
		M1_APN_2	297..769	CDD:189008	136/478 (28%)
		ERAP1_C	846..1138	CDD:288671	41/150 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950