DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and CG4467

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001036747.1	Gene:	CG4467 / 42747	FlyBaseID:	FBgn0039064	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	170/757 - (22%)
Similarity:	296/757 - (39%)	Gaps:	179/757 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EPRLPAKVKPFHYDIRL---LTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKITL 102
            |..||..|:|..|.:.:   ||.|:      ..|.|.|.:|.:|.||.:|||:..:::..|.|..
  Fly   135 EKMLPTSVRPLRYMVTIHPNLTTLD------VKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVT 193

  Fly   103 FGETSNYRLRSVRFNN--DRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKT 165
            .| ...|.|:.|:...  .|:.:.:...:.|....:|.|::.:...:. .:.:|:::..|.:...
  Fly   194 PG-PKGYALKIVKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLN-PEPEGFYVDQYESSNG 256

  Fly   166 SEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVT------------------------------ 200
            .|:: .:.:.|..|..|...|.||||.::|.|.::
  Fly   257 VERL-LAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGLL 320

  Fly   201 --------------------------------------------MGHHKRFQ--SYGNMKVQAVL 219
                                                        :|..|..|  :|..:|.:..
  Fly   321 RDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNP- 384

  Fly   220 PNREIQDYVWSVH-EVTP----TI--PTHLLAFSVN-NFNCRYSQAASLSPVRFRTCAQSADVRA 276
            |.|.|.....|:: .:||    |:  ||...|:.|| |.|.:.|...|||     ....|:..||
  Fly   385 PVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLS-----QSTGSSIKRA 444

  Fly   277 --------------TSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRS 327
                          :||....:..:||:|...|.::.||.|:|.:.:.......:.:.|||..::
  Fly   445 PSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLKT 509

  Fly   328 KHLLLREDGPMSKEKLQTLEL-IAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSK 391
            .  .|.:...::.|:.|...| ||..|...:|..:.......|:||.|||..|....|:..||..
  Fly   510 S--FLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGLIQYLGIHALAPLQET 572

  Fly   392 MGRR--ILLRYRESSMMYESQVGGISLVPLSSNASLNAETQLYQKATSLTSMLIGFLGNETFYDG 454
            ...|  .||:...:::..::..|..|::..:|:.. |.|....||..::.|||...:|.:.|...
  Fly   573 WPLREMYLLKMATAALDIDAIQGWDSIMNGTSHDG-NNEEFFVQKTAAIFSMLHTAIGEDRFRGC 636

  Fly   455 LQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEVFL 519
            |...:..|.|.::.|...|    ....::|...|  ::|.:|..||.|.|:||:||.:.|:.:.:
  Fly   637 LGSFLKVNRFRTAEPTDLW----TICTKKANGSK--NIKDMMTLWTHQPGFPLLTVTKMGNSISI 695

  Fly   520 KQ-----------------GHALNRS----------------------SSHLWWI-PLTYLIEGG 544
            .|                 |:..|::                      :.|:.|| |:||:.:..
  Fly   696 SQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVTDIN 760

  Fly   545 SLSKNLKPKAWLSPNSHGIKLNDIVPRN-QWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSI 608
            ::|:.|    |:    ..:.:...||.| :||.:|....|||||.|::..|..|...|..:....
  Fly   761 NVSETL----WM----QNVDVTFNVPENVKWIKVNAIQNGYYRVVYNDDNWASLIEELAANPNRF 817

  Fly   609 NVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEPL 650
            ...:|..::||...|.:.:||.....:|:::|:..|..|.|:
  Fly   818 TSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPM 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	118/553 (21%)
		ERAP1_C	574..>652	CDD:338125	23/77 (30%)
		dnaA	630..>701	CDD:234667	5/21 (24%)
CG4467	NP_001036747.1	Peptidase_M1	138..593	CDD:279741	101/471 (21%)
		GluZincin	145..682	CDD:301352	122/560 (22%)
		ERAP1_C	784..1078	CDD:288671	22/76 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020