DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and CG42335

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_732655.3	Gene:	CG42335 / 42558	FlyBaseID:	FBgn0259237	Length:	924	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	169/703 - (24%)
Similarity:	298/703 - (42%)	Gaps:	109/703 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LLLCLCQVACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKT--TNQ 85
            ||:|:...|         :.||...|.|.||::.:.....|.....:.|.|.|::....|  ..|
  Fly    15 LLICVTNAA---------DYRLEGSVVPSHYNLTIGVLRNSVEPTIFDGEVSITLRVVGTLEVQQ 70

  Fly    86 VVLHVGRVSI-------------ESKKIT-LFGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKS 136
            ::||...:.|             |:..|: |..|.:..::|            |...::...||:
  Fly    71 IILHADTLDITECWLLDAAGAQVEAIDISRLIYEAATQQVR------------VPLTEAAQPGKN 123

  Fly   137 YVLSVEFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTM 201
            |.|..::...:..|.. |:|...|:...|:...|.:::...|...|..:|.||||:|||.|.:.:
  Fly   124 YTLGFKYTGHIRTDMA-GFFSASYVERDTNVTRWLALTQMQRINARLVLPCFDEPALKAQFQLQI 187

  Fly   202 GHHKRFQSYGNMKV---QAVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPV 263
            .....:||..|.|:   :|:..:|.:..:     :.||.:.|:||||.|.|::.|.:::
  Fly   188 VRPNGYQSIANTKLKETKALSQDRFVDHF-----KETPVMSTYLLAFMVANYSARGNES------ 241

  Fly   264 RFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVD-----DFPTEAMENFGLV 323
            .|....:......|.|:..:..|::.....:.|  .|..::...|:.     .||...|||:||:
  Fly   242 EFAVLTRPEFYDNTEFSYHVGQQVVSAYGELFQ--SPYAELGNDVLQYASSPRFPHNGMENWGLI 304

  Fly   324 VYRSKHLLLREDGPMS--KEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVD 386
            :| |..:|::|.|...  .:|...:.:||||.:||||.:.:....:|..||.|..|.|::.....
  Fly   305 IY-SDDVLIQEPGYSDDWSDKEFAIRIIAHETSHMWFGDSVTFSWWSYFWLNEAFARYYEYFMAH 368

  Fly   387 HL--QSKMGRRILLRYRESSMMYESQVGGISLVPLSS-NASLNAETQL--------YQKATSLTS 440
            .|  ...:..:.::|..:.....::|.|   ..|::| .:.:...:|:        |.|...:..
  Fly   369 QLYPDYHLDEQFVVRQMQLIFGTDAQNG---TQPMTSPESEIQTPSQIAYKFSGIAYAKGACIVR 430

  Fly   441 MLIGFLGNETFYDGLQRHMWQNSFGSSTP-DLFWRSLQLASEREATFDKTWDVKSI--MDTWTMQ 502
            |....:|.|.|...::.::.|....::.| :||:...:       .:.|..||..:  :..:|.|
  Fly   431 MWRNLMGAENFDTAIRSYLQQYHLTNTVPYNLFYHLFE-------HWPKNQDVDLVDFLTDYTEQ 488

  Fly   503 SGYPLVTV--IRNGSEVFLKQGH-ALNR---SSSHL-WWIPLTYLIEGGSLSKNLKPKAWLSPNS 560
            .|||::.|  ::....|.::|.. .||:   |::.| :.:|:|:.........||.|..:|....
  Fly   489 VGYPMIIVKALQGNKVVTVEQSRFLLNKDDGSNATLKYTVPITFTTNLERDFYNLTPYKYLHKTV 553

  Fly   561 HGIKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQ--LLATTLFNDFRSINVLNRAQIVSDVLFL 623
            :.:.| |......|||.||:...|.||.||:...:  |||.:..| ...|.|.|||||:.|:...
  Fly   554 NVLWL-DFTSPIDWILFNLRQSNYQRVFYDDTLREGLLLAISATN-HSGIPVENRAQIIDDLFNF 616

  Fly   624 WNQDLLAWSTALNVLKYIIDEDEYEPLMAFVVGWTNGFWGISTESSFNIAKWL 676
            .....:.::.....|:|:..|.||.|            |....|:...:||.|
  Fly   617 AQAQYVDYADVFRFLEYLAKEVEYVP------------WYAVYENLNTVAKRL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	108/487 (22%)
		ERAP1_C	574..>652	CDD:338125	28/79 (35%)
		dnaA	630..>701	CDD:234667	11/47 (23%)
CG42335	NP_732655.3	Peptidase_M1	26..425	CDD:279741	100/428 (23%)
		M1_APN_2	34..492	CDD:189008	111/494 (22%)
		ERAP1_C	567..874	CDD:288671	32/104 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020