DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7653 and LNPEP

DIOPT Version :9

Sequence 1:NP_001356886.1 Gene:CG7653 / 34935 FlyBaseID:FBgn0028935 Length:710 Species:Drosophila melanogaster
Sequence 2:NP_005566.2 Gene:LNPEP / 4012 HGNCID:6656 Length:1025 Species:Homo sapiens


Alignment Length:702 Identity:189/702 - (26%)
Similarity:340/702 - (48%) Gaps:78/702 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KCLLSERENCYKNVALYGLLLLLCLCQVACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSANH 67
            :|..: :|.|:|.....||:.     ..|.:.|...:.:.|||..|.|..|::.|..:|.|.   
Human   133 RCTFT-KEGCHKKNQSIGLIQ-----PFATNGKLFPWAQIRLPTAVVPLRYELSLHPNLTSM--- 188

  Fly    68 SYTGIVKISIHAQKTTNQVVLH-----VGRVSIESKKITLFGETSNYRLRSVRFNNDRKYMVVTF 127
            ::.|.|.||:.|.:.|..::||     :.||:..|   .:..:.....:....::..   :.:..
Human   189 TFRGSVTISVQALQVTWNIILHSTGHNISRVTFMS---AVSSQEKQAEILEYAYHGQ---IAIVA 247

  Fly   128 NQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPS 192
            .::||.|.:|.|.:|:...::.... |::...|.: :::||.:::.:.|.....|:..|.||||:
Human   248 PEALLAGHNYTLKIEYSANISSSYY-GFYGFSYTD-ESNEKKYFAATQFEPLAARSAFPCFDEPA 310

  Fly   193 LKATFNVTMGHHKRFQSYGNM--KVQAVLPNREIQDYVWSVHEVTPTI--PTHLLAFSVNNFNCR 253
            .||||.:.:...:::.:..||  |...||.:..:||      |.:.::  .|:|:||.|.... .
Human   311 FKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQD------EFSESVKMSTYLVAFIVGEMK-N 368

  Fly   254 YSQAASLSPVRFRTCAQSADVRATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAME 318
            .||..:.:.|......:.  :....:|.:...::|||.....::..||:|:|.:.:.||...|||
Human   369 LSQDVNGTLVSIYAVPEK--IGQVHYALETTVKLLEFFQNYFEIQYPLKKLDLVAIPDFEAGAME 431

  Fly   319 NFGLVVYRSKHLLLRED-GPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKS 382
            |:||:.:|.:.||...: ..|:..||.| ::||||:||.||.||:.|..::||||.||.|.:.:.
Human   432 NWGLLTFREETLLYDSNTSSMADRKLVT-KIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEY 495

  Fly   383 LAVDHLQSKMGR-RILLRYRESSMMYESQVGGISLVPLSSNASLNAETQL--------YQKATSL 438
            .:::.:..::.. ...|..|..:|..:|.   .|..|:||  |:.:..|:        |.|.:||
Human   496 FSLEKIFKELSSYEDFLDARFKTMKKDSL---NSSHPISS--SVQSSEQIEEMFDSLSYFKGSSL 555

  Fly   439 TSMLIGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQS 503
            ..||..:|..:.|...:..::..:|:.|...|..|.|.     .|.| ::|.|||.:|.|||:|.
Human   556 LLMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSF-----NEVT-NQTLDVKRMMKTWTLQK 614

  Fly   504 GYPLVTVIRNGSEVFLKQGH-ALN-------RSSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNS 560
            |:|||||.:.|.|:|::|.. .||       ..:|:||.|||:|:.||.:.|| .:..:.|...|
Human   615 GFPLVTVQKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVTEGRNYSK-YQSVSLLDKKS 678

  Fly   561 HGIKLNDIVPRNQWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWN 625
            ..|.|.:.|   .|:.:|:...|||.|:|.:..|:.|...|..:...::..:||.:::::..|..
Human   679 GVINLTEEV---LWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLSDKDRANLINNIFELAG 740

  Fly   626 QDLLAWSTALNVLKYIIDEDEYEPLMAFVVGWTNGFWGISTESSFNIAKWLG 677
            ...:....|.:::.|:.:|:...|:...:         ..|:..:|:.:.||
Human   741 LGKVPLKRAFDLINYLGNENHTAPITEAL---------FQTDLIYNLLEKLG 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7653NP_001356886.1 M1_APN-Q_like 52..500 CDD:341064 124/466 (27%)
ERAP1_C 574..>652 CDD:338125 17/77 (22%)
dnaA 630..>701 CDD:234667 8/48 (17%)
LNPEPNP_005566.2 Dileucine internalization motif. /evidence=ECO:0000255 53..54
Dileucine internalization motif. /evidence=ECO:0000255 76..77
Tankyrase binding 96..101
M1_APN_2 175..617 CDD:189008 128/473 (27%)
Substrate binding. /evidence=ECO:0000250 428..432 2/3 (67%)
ERAP1_C 689..1009 CDD:314669 21/104 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155398
Domainoid 1 1.000 45 1.000 Domainoid score I12219
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.950

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