DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and erap1b

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_956500.2	Gene:	erap1b / 393175	ZFINID:	ZDB-GENE-040426-934	Length:	963	Species:	Danio rerio

Alignment Length:	708	Identity:	179/708 - (25%)
Similarity:	310/708 - (43%)	Gaps:	122/708 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVS 94
            ::.|.:...:::.|||..:.|.||::.:..:|.|.   .:||.|:|.|...:.|..::||...:.
Zfish    33 ISSSGEPFPWNKMRLPDTISPLHYNLLIHPNLTSL---DFTGSVQIQIEVLQDTKTIILHSKNLQ 94

  Fly    95 IESKKITLFGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFIRH 159
            |.|.::..........|:.:.:...::..:|:....|..|..|.:.:.|...:: :...|::...
Zfish    95 ISSARLLDANIAQQQPLKVLEYPYFQQIALVSDKALLKRGHVYSVELHFAANLS-ESFHGFYKST 158

  Fly   160 YINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNM-KVQAV-LPNR 222
            |...|...::..| :.|.....|...|.||||:.||.|:|.:....:..:..|| |::.: |.|.
Zfish   159 YRTSKGDVRVVAS-TQFEATSARAAFPCFDEPAFKANFSVQIRREAKHIALSNMPKLRTLELKNG 222

  Fly   223 EIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSP-----VRFRTCAQSADVRATSFAAQ 282
            ..:|.    .:|:..:.|:|:|:.|::|       .|:|.     |:....|....:....||..
Zfish   223 LFEDQ----FDVSVKMSTYLVAYIVSDF-------LSISKTSQHGVQISVYAVPEKIDQAEFALD 276

  Fly   283 MAPQILEFLDRVLQVALPLEK--------------------IDQLVVDDFPTEAMENFGLVVYRS 327
            .|.::|:|.|....:..||.|                    :|...:.||.:.||||:||..||.
Zfish   277 AAVKLLDFYDDYFDIPYPLPKQEKPTIKHAKEEFSVYIICFVDLAAIPDFQSGAMENWGLTTYRE 341

  Fly   328 KHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVD----HL 388
            ..||.......:.:||....:||||:||.||.||:.|..::||||.||.|.:.:.::|:    .|
Zfish   342 SALLFDPHKSSASDKLGITMIIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEFVSVNITNPEL 406

  Fly   389 QSK---MGRRILLRYRESSMMYES-QVGGISLV-PLSSNASLNAETQ------LYQKATSLTSML 442
            |.:   :|:           .:|: :|..:|.. |:|:.....|:.|      .|.|...:.:||
Zfish   407 QVEDYFLGK-----------CFEAMEVDSLSSSHPVSTPVENPAQIQEMFDDVSYDKGACILNML 460

  Fly   443 IGFLGNETFYDGLQRHMWQNSFGSSTPDLFWRSLQLASEREA------------------TFDKT 489
            ..||..:.|..|:.:::...|:.::.....|.||....:.:.                  |....
Zfish   461 REFLTPKIFKLGIVKYLKHYSYQNTVNSNLWESLTNVCDSDGLDEGRLKGDESCRHSASNTGASK 525

  Fly   490 W------DVKSIMDTWTMQSGYPLVTVIRNGSEVFLKQ-----GHALNRSSSHLWWIPLTYLIEG 543
            |      |||::|:|||:|.|:||:|:...|.||.|.|     ...|:::||.||.:||||:...
Zfish   526 WHSEDELDVKAMMETWTLQEGFPLITIAVKGREVRLSQERYLKSDDLSQTSSFLWQVPLTYITSD 590

  Fly   544 GSLSKN--LKPKAWLSPNSHGIKLNDI--VPRN-QWILLNLQAVGYYRVNYDELTWQLLATTLFN 603
            .:....  ||.|            .|:  :|.. .||..|:...|||.|:|:...|..|.|.|.:
Zfish   591 STTVHRFLLKTK------------TDVLYLPEEVDWIKFNVDMSGYYIVHYEGSGWDDLITLLKH 643

  Fly   604 DFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDEDEYEPLMAFVVGWTNGF 661
            :..:::..:||.::::...|.:...|....||::..|:..|.|..|:       |.||
Zfish   644 NHTALSSNDRASLINNAFQLVSVGKLPLDKALDLTLYLSKETEIMPV-------TQGF 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	123/513 (24%)
		ERAP1_C	574..>652	CDD:338125	22/77 (29%)
		dnaA	630..>701	CDD:234667	9/32 (28%)
erap1b	NP_956500.2	Peptidase_M1	46..453	CDD:279741	109/433 (25%)
		M1_APN_2	54..548	CDD:189008	127/520 (24%)
		ERAP1_C	615..932	CDD:288671	24/87 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950