DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and Trhde

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001102461.1	Gene:	Trhde / 366894	RGDID:	728895	Length:	1066	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	193/716 - (26%)
Similarity:	328/716 - (45%)	Gaps:	99/716 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TQLYDEPRLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKI 100
            |||    ||...:||.||::.|...:|   |.:::|.|.:.|..|..|..||||..||::|..::
  Rat   179 TQL----RLSGHLKPLHYNLMLTAFME---NFTFSGEVNVEIACQNATRYVVLHASRVAVEKVQV 236

  Fly   101 T--------------LFGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTMDQ 151
            .              |:.:|              :.:||..|::|...:.|.|.:.: ..:..::
  Rat   237 AEDRAFGAVPVAGFFLYPQT--------------QVLVVVLNRTLDAQRHYNLKIIY-NALIENE 286

  Fly   152 RDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQ 216
            ..|:|...|:  ...|:.:..|:.|:....|...|.||||..||||.:::.|...:.|..||.|:
  Rat   287 LLGFFRSSYV--IHGERRFLGVTQFSPTHARKAFPCFDEPIYKATFKISIKHQATYLSLSNMPVE 349

  Fly   217 AVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATS--F 279
            ..:  .|...:|......||.:.|:.||:::.||.  |.:..:.|.|..|..|:...:|..|  :
  Rat   350 TSV--FEEDGWVTDHFSQTPLMSTYYLAWAICNFT--YRETTTKSGVVVRLYARPDAIRRGSGDY 410

  Fly   280 AAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQ 344
            |..:..:::||.:...:|...|.|:|.|.|...|..||||:||.::..:.:||..........|.
  Rat   411 ALHITKRLIEFYEDYFKVPYSLPKLDLLAVPKHPYAAMENWGLSIFVEQRILLDPSVSSISYLLD 475

  Fly   345 TLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMG---RRILLRYRESSMM 406
            ...:|.||:.|.||.:|:....:.|:||.||.|.||:.:..|:|.....   :|.|.......|:
  Rat   476 VTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEFVGTDYLYPSWNMEKQRFLTDVLHEVML 540

  Fly   407 YESQVGGISLVPLSSNASLNAETQ------LYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSFG 465
            .:   |..|..|:|.......:..      .|:|..:|..||..|:|:..|..|||.::..:.:|
  Rat   541 LD---GLASSHPVSQEVLRATDIDKVFDWIAYKKGAALIRMLANFMGHSVFQRGLQDYLTIHKYG 602

  Fly   466 SSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRN---GSEVFLKQGH---- 523
            ::..:..|.:|..|.:|..   |..:::.:||.||:|.|||::|::.|   .:.:.:.|.|
  Rat   603 NAARNDLWNTLSEALKRNG---KYVNIQEVMDQWTLQMGYPVITILGNMTAENRILITQQHFIYD 664

  Fly   524 ------ALN-RSSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNS--HGIKLNDIVPRNQWILLNL 579
                  ||. ::||:||.|||| ::.|.....:.:...|:|..|  |.|...|   :..|||.|:
  Rat   665 IGAKTKALQLQNSSYLWQIPLT-IVVGNRSHVSSEAIIWVSNKSEHHRITYLD---KGSWILGNI 725

  Fly   580 QAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDE 644
            ...||:|||||...|:||...|..:...::|.|||.::.|...|.....|..:..|.:::|:.:|
  Rat   726 NQTGYFRVNYDLRNWRLLIDQLIRNHEVLSVSNRAGLIDDAFSLARAGYLPQNIPLEIIRYLSEE 790

  Fly   645 DEYEPLMAFVVGWTNGFWGISTESSFNIAKWL------GIAAKWYAEFISYTFDKFVVQDPNQNL 703
            .::.|            |..::.:.:.:.|.|      .|..::..:.::.|:.|  :..|..|.
  Rat   791 KDFLP------------WHAASRALYPLDKLLDRMENYNIFNEYILKQVATTYSK--LGWPKNNF 841

  Fly   704 N 704
            |
  Rat   842 N 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	124/472 (26%)
		ERAP1_C	574..>652	CDD:338125	26/77 (34%)
		dnaA	630..>701	CDD:234667	11/76 (14%)
Trhde	NP_001102461.1	M1_APN-Q_like	190..635	CDD:341064	125/474 (26%)
Trhde	NP_001102461.1	ERAP1_C	720..1044	CDD:403137	35/137 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349248
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950