DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and CG10602

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_609916.5	Gene:	CG10602 / 35146	FlyBaseID:	FBgn0032721	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	143/727 - (19%)
Similarity:	270/727 - (37%)	Gaps:	182/727 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QVACSAKT-QLYD----EPRLPAKV---------KPFHYDI----------RLL-THLESSANHS 68
            |.|..|:| .:||    .|...||:         ||.::.:          :|| .:.....|..
  Fly     9 QWATFARTWHIYDCTWQNPFESAKLVKTHLLGLQKPIYHPMISTRGLCTSHKLLPIYQVQKRNMG 73

  Fly    69 YTGIVKISIHAQK---TTNQVVLHVGRVSIESKKITLFGETSNYRLRSVRFNNDRKYMVV----T 126
            ..|:|..|.::|.   ||....|: .::...:.||.  |... :|.:.:..|.|:..:.|    .
  Fly    74 RLGVVDPSSYSQPDLITTEHSALN-WKIDFAATKIQ--GSVL-HRFKVLTANLDKILLDVRDINV 134

  Fly   127 FNQSLLMGKSYVLSVEF---------GRPMTMDQRDGY---FIRHYINWKTSEKI----W----- 170
            .|.:||.|.| .|.:.|         |:.:|::...|.   .:...|:::||...    |
  Fly   135 TNATLLAGGS-ELPINFFISDAVDDIGQKLTLELPSGTAKGSLNVRIDYETSSSASGLQWLNPTQ 198

  Fly   171 -------YSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNREIQDYV 228
                   |..|.......|:.:|..|.|::|.|::.|:.|.....:..:..:....|.:.:
  Fly   199 TLGKEHPYMFSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSALIDKKEPGKTL---- 259

  Fly   229 WSVHEVTPTIPTHLLAFSVNNFNCR--------YSQAASLSPVRFRTCAQSADVRATSFAAQMAP 285
              ..:..| ||.:|:|.::.....|        :::.|.:.     .||:.....||
  Fly   260 --FKQEVP-IPAYLVAIAIGKLVSRPLGENSSVWAEEAIVD-----ACAEEFSETAT-------- 308

  Fly   286 QILEFLDRVLQVALPL------EKIDQLVV-DDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKL 343
                    :|:.|..|      ::.|.||: ..||...|||..|.....  .||..|..::
  Fly   309 --------MLKTATELCGPYVWKQYDLLVMPPSFPFGGMENPCLTFVTP--TLLAGDKSLA---- 359

  Fly   344 QTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQ--SKMGRRILLRYRESSMM 406
               :::|||:||.|..||:...::...||.||...:.:|..|..:|  .::..::|....:....
  Fly   360 ---DVVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVFVESKIVGRMQGAKELDFKMLSNLTDLQEC 421

  Fly   407 YESQVGGIS-----LVPLSSNASLNAETQL-YQKATSLTSMLIGFLGNETFY-----DGLQRHMW 460
            ..:|:....     :|.||:....:|.:.: |.|.::....|....|..|.:     |.|:::.:
  Fly   422 IRTQLNKTPELTKLVVDLSNCGPDDAFSSVPYIKGSTFLRYLEDLFGGPTVFEPFLRDYLKKYAY 486

  Fly   461 QN----SFGSSTPDLFWRSLQLASEREATFDK----TWDVKSIMDTWTMQSGYPLVTVIRNGSEV 517
            ::    .|.|:..|.|     :.::::   ||    .||:      |....|.|  .||.|..|.
  Fly   487 KSIETKDFQSALYDYF-----IDTDKK---DKLSAVDWDL------WLKSEGMP--PVIPNFDES 535

  Fly   518 FLKQGHALNRSSSHLWWI-PLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVPRNQWILLNLQA 581
            ...    :.:..:.||.. .:..|.:...:...:.....:......|:..|||..|:.
  Fly   536 LAN----VTKELASLWSSKSVAELADSAEIKTTISIHQLIDFLGKLIESKDIVDLNEG------- 589

  Fly   582 VGYYRVNYDELTWQLLATTLFN-DFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDED 645
                ::|..|.|:.|.::.... .||...::.||:::..:     .::|.::.:...:|:.
  Fly   590 ----KINLLESTYNLKSSKNAEVRFRLNRLIIRARLIKRL-----DEILEFANSNFRMKFC---- 641

  Fly   646 EYEPLMAFVVGW 657
              .|:...:.||
  Fly   642 --RPIYRDLAGW 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	104/529 (20%)
		ERAP1_C	574..>652	CDD:338125	11/78 (14%)
		dnaA	630..>701	CDD:234667	4/28 (14%)
CG10602	NP_609916.5	Ribosomal_L13	16..>50	CDD:294238	8/33 (24%)
		leuko_A4_hydro	79..681	CDD:274120	127/657 (19%)
		M1_LTA4H	79..520	CDD:189006	99/496 (20%)
		Leuk-A4-hydro_C	541..680	CDD:286244	21/133 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462059
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840