DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and CG9806

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_572643.1	Gene:	CG9806 / 31994	FlyBaseID:	FBgn0030222	Length:	911	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	193/725 - (26%)
Similarity:	330/725 - (45%)	Gaps:	77/725 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YGLLLLLCLCQVACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLES-SANHSYTGIVKISIHAQKT 82
            |.::|.||| .:..:..|        .:.::|.||::.|||.:|. ..:.:::|.|.|.:...:.
  Fly     7 YLIVLHLCL-PIGGTGAT--------ASNLRPLHYNLSLLTEVEPLKLSGNFSGEVIIRLRVWRE 62

  Fly    83 TNQVVLHVGRVSIESKKITLFGETSNYR--LRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGR 145
            |..::|....:.: .:.:.|....:..|  :|.:...:....:.:.||..|.:|:.|.|.|:|..
  Fly    63 TRTIILSNNGLQV-GENVLLVRRNTGGRVTVRKMWQASSVHQLGIVFNSMLWLGEEYTLVVQFSG 126

  Fly   146 PMTMDQRDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSY 210
            .::  :..|||:..|::.|...: |.:|:....|......|.|:..:..|.|.:.:.|.:...:.
  Fly   127 QLS--RASGYFVGGYMDSKHHPQ-WIAVTQLAPNLANTVFPCFENRTFLAPFILNLAHPRGTNAV 188

  Fly   211 GNMKVQAVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVR 275
            .||:|... .:.|..||||:..:.||.:....||||:|.|..|.|......|. ..|..:.....
  Fly   189 SNMRVLKT-SDHEKDDYVWTTFQQTPAMSVQKLAFSINRFTNRTSAEIPKGPA-LTTWLRPKIAD 251

  Fly   276 ATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSK 340
            ...:|..:.|||:.|...:.....|..||||||:.|...::.|:.|||.|.....|.......::
  Fly   252 QGDYAISITPQIIVFFISLFGKPYPAMKIDQLVLPDTAYQSHEHLGLVSYPEAAFLYSAQRSTTR 316

  Fly   341 EKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSM 405
            .|.|....:|.|.||.|..:|.....|   ||..||:.|....|||:::...      |:.|.||
  Fly   317 AKQQVASHVAQEFAHHWLSDLENAALY---WLHNGLSDYVSGFAVDNVEPAW------RFHELSM 372

  Fly   406 MYES-----QVGGISLVPLS-SNASLNAETQLYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSF 464
            :.::     :....|..|:| :.||.:::||..||:..|..||...:|.:.|.:.|:.::.::..
  Fly   373 VRQALAVLVEDSKSSAYPMSLAYASKSSDTQANQKSALLFRMLHSLIGTQAFLNALRLYLQRSHK 437

  Fly   465 GSSTPDLF-WRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRN--------GSEVFLK 520
            |||:...| |.:||..|:.:.:..:...|..:||:||||.||||:.|:||        ..|.||:
  Fly   438 GSSSNQAFLWHTLQEESDNQMSLRQDIKVSQLMDSWTMQPGYPLIRVVRNYDTNEVTVTQERFLR 502

  Fly   521 QGHALNRSSSHLWWIPLTYLIEGGSLSKNLKPKAWLS----PNSHGIKLNDIVPRNQWILLNLQA 581
            ....|.:.....||:|||:...|.....:..|..||:    ..:..:.||::...::|::.||:.
  Fly   503 NPGKLMQKRQQCWWVPLTFATAGIDSFVSTLPSEWLTCQGRQTASPLILNEVAQPDKWVVFNLRL 567

  Fly   582 VGYYRVNYDELTWQLLATTLF-NDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYIIDED 645
            ....|:.|||..|||:...|. .:..||:...|||::||||.|....::.:..|||.|.::.:||
  Fly   568 ATPCRITYDERNWQLIGNALSGTNASSIDRFTRAQLISDVLNLAGAGVVTYDLALNFLGHLRNED 632

  Fly   646 EYEPLMAFVVGWTNGFWGISTESSFNIAKWLGIAAK----------WYAEFISYTFDKFVVQD-- 698
            |      |:|      |    :::....:||....:          :..:.:...||:...:|
  Fly   633 E------FIV------W----QAADTYLEWLHRTLRQTTIISTFKGFMRDLLQTKFDELFKRDGS 681

  Fly   699 --PNQNLNSL 706
              .|.|:..|
  Fly   682 AAENANITEL 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	121/457 (26%)
		ERAP1_C	574..>652	CDD:338125	28/78 (36%)
		dnaA	630..>701	CDD:234667	15/84 (18%)
CG9806	NP_572643.1	ERAP1_C	561..878	CDD:288671	38/147 (26%)
		Peptidase_M1	25..392	CDD:279741	98/381 (26%)
		GluZincin	30..480	CDD:301352	126/464 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950