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Protein Alignment CG7653 and ANPEP

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001141.2	Gene:	ANPEP / 290	HGNCID:	500	Length:	967	Species:	Homo sapiens

Alignment Length:	719	Identity:	204/719 - (28%)
Similarity:	327/719 - (45%)	Gaps:	116/719 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KTQLYDEPRLPAKVKPFHYDIRLLTHLESSANHSYT--GIVKISIHAQKTTNQVVLHVGRVSIES 97
            :::.::..|||..:||..|.:.|..:|..:....|.  |...:....::.|:.:::|       |
Human    67 QSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIH-------S 124

  Fly    98 KKITLFGETSNYR--LRSV-----------RFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRPMTM 149
            ||:. :..:..:|  ||.|           ......:|:||....||:....|.:..||...:.
Human   125 KKLN-YTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELA- 187

  Fly   150 DQRDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMK 214
            |...|::...|:.....:.:  :.:.......|.:.|.||||::||.||:|:.|.|...:..||.
Human   188 DDLAGFYRSEYMEGNVRKVV--ATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNML 250

  Fly   215 VQAVLPNREI-QDYVWSVHE--VTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRA 276
            .:.  |:..: :|..|:|.|  .||.:.|:||||.|:.|:  |.:..:.:.|..|..|:.:.:.|
Human   251 PKG--PSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFD--YVEKQASNGVLIRIWARPSAIAA 311

  Fly   277 --TSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMS 339
              ..:|..:...||.|.........||.|.||:.:.||...||||:|||.||...||.......|
Human   312 GHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSS 376

  Fly   340 KEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESS 404
            ..|.:.:.:||||:||.||.||:.::.::||||.||.|.|.:.|..|:.:.        .:....
Human   377 SNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEP--------TWNLKD 433

  Fly   405 MMYESQVGGISLV-------PLSSNAS-LNAETQL--------YQKATSLTSMLIGFLGNETFYD 453
            :|..:.|..:..|       |||:.|| :|...|:        |.|..|:..||..||..:.|..
Human   434 LMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQ 498

  Fly   454 GLQRHMWQNSFGSSTPDLFWRSLQLA-SEREATFDKTWDVKSIMDTWTMQSGYPLVTVIRNGSEV 517
            ||..::...::.::.....|..||.| :.|......|  |:.||:.||:|.|:|::||  :.|..
Human   499 GLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTT--VRDIMNRWTLQMGFPVITV--DTSTG 559

  Fly   518 FLKQGHAL-------NRSS--SHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKL---NDI-- 568
            .|.|.|.|       .|.|  :::|.:|:|.:.:|     ..:...||      |.:   ||:
Human   560 TLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDG-----RQQQDYWL------IDVRAQNDLFS 613

  Fly   569 VPRNQWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWST 633
            ...|:|:||||...|||||||||..|:.:.|.|..|..:|.|:|||||::|...|.:...:..:.
Human   614 TSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTL 678

  Fly   634 ALNVLKYIIDEDEYEPLMAFVVGWTNGFWGISTESSFNIAKWLGIAAKWYAEFISYTFDKFVVQD 698
            |||...::|:|.:|.|..|          .:|:.|.|.:                 .||:..|..
Human   679 ALNNTLFLIEERQYMPWEA----------ALSSLSYFKL-----------------MFDRSEVYG 716

  Fly   699 PNQN 702
            |.:|
Human   717 PMKN 720

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.