DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and LVRN

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	788	Identity:	207/788 - (26%)
Similarity:	332/788 - (42%)	Gaps:	176/788 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YDEPRLPAKVKPFHYDIRLLTHLE----SSANHSYTGIVKISIHAQKTTNQVVLH---------- 89
            :|:.|||..:.|.|||:.|...|.    .:.:..:||.|.|::.....|::::||
Human    93 WDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFTGRVNITVRCTVATSRLLLHSLFQDCERAE 157

  Fly    90 -------------VGRVSIESKKITLFGETSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSV 141
                         ||||.::                .|.|..|.:|||:..::.|..|.||.|.:
Human   158 VRGPLSPGTGNATVGRVPVD----------------DVWFALDTEYMVLELSEPLKPGSSYELQL 206

  Fly   142 EFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKR 206
            .|...:..|.|:|.|:..|.:  ..|:.....|.....:.|...|.||||:||||||:||.||..
Human   207 SFSGLVKEDLREGLFLNVYTD--QGERRALLASQLEPTFARYVFPCFDEPALKATFNITMIHHPS 269

  Fly   207 FQSYGNMKVQAVLPNREIQDYVWSV--HEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCA 269
            :.:..||.........::....|:|  ...||.:||:|:||.:    |.|....       || .
Human   270 YVALSNMPKLGQSEKEDVNGSKWTVTTFSTTPHMPTYLVAFVI----CDYDHVN-------RT-E 322

  Fly   270 QSADVR-----------ATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLV 323
            :..::|           :..||..:...|..||:.:..::..|.|.|.:.:..|...||||:||:
Human   323 RGKEIRIWARKDAIANGSADFALNITGPIFSFLEDLFNISYSLPKTDIIALPSFDNHAMENWGLM 387

  Fly   324 VYRSKHLLLREDGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHL 388
            ::....|||.....::::|.....:::||:.|.||.||:.|:.::::||.||.|.||:...:::.
Human   388 IFDESGLLLEPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYF 452

  Fly   389 QSKMGR-RILLRYRESSMMYESQVGGISLVPLSSNASLNAETQ------LYQKATSLTSMLIGFL 446
            ..|:.| .|.......:::.|........|.:.......:|.|      .|.|..|:..||..||
Human   453 NPKLPRNEIFFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFL 517

  Fly   447 GNETFYDGLQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVI 511
            ....|...|:.::...|:.::..|..||..|:|.:.::|......:|:|||:||.|||:|::|:
Human   518 NEHLFVSALKSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITL- 581

  Fly   512 RNGSEVFLKQ-----GHALNR---SSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDI 568
             |.|...:||     .:..||   :|:..|.:|:.::..|     ..:|..||..:|      .:
Human   582 -NVSTGVMKQEPFYLENIKNRTLLTSNDTWIVPILWIKNG-----TTQPLVWLDQSS------KV 634

  Fly   569 VPRNQ-------WILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQ 626
            .|..|       |::|||...||||||||:|.|:.|...|..|.::|.|::|.|::.|...|...
Human   635 FPEMQVSDSDHDWVILNLNMTGYYRVNYDKLGWKKLNQQLEKDPKAIPVIHRLQLIDDAFSLSKN 699

  Fly   627 DLLAWSTALNVLKYIIDEDE-------------------------YEPLMAFVVGWTNGFWG--- 663
            :.:...|||.:.||:.:|||                         |..|..:::...|..|.
Human   700 NYIEIETALELTKYLAEEDEIIVWHTVLVNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYS 764

  Fly   664 -----------------ISTESSFNIAKWLGIA----------AKWYAEFISYTFDKFVVQDPNQ 701
                             ||.|..|..|.|||:.          |||             |..|.
Human   765 TIIRENVLALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKW-------------VDHPE- 815

  Fly   702 NLNSLDYP 709
              |.:.||
Human   816 --NEIPYP 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	128/494 (26%)
		ERAP1_C	574..>652	CDD:338125	33/102 (32%)
		dnaA	630..>701	CDD:234667	25/125 (20%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91
		Peptidase_M1	97..506	CDD:279741	113/438 (26%)
		M1_APN_2	105..577	CDD:189008	133/501 (27%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	50/190 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950