DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and Npepps

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_032968.2	Gene:	Npepps / 19155	MGIID:	1101358	Length:	920	Species:	Mus musculus

Alignment Length:	706	Identity:	186/706 - (26%)
Similarity:	302/706 - (42%)	Gaps:	105/706 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LLLLLC--------LCQVACSAKTQLYDEPRLPAKVKPFHYDIRLLTHLESSANHSYTGIVKISI 77
            |||||.        |..:..:|..:.....||||:|.|.:|.:.|...|   .:.::.|.::.:.
Mouse    24 LLLLLSRSSRRRRRLHSLGLAAMPEKRPFERLPAEVSPINYSLCLKPDL---LDFTFEGKLEAAA 85

  Fly    78 HAQKTTNQVVLHVGRVSIESKKITL-FGETSNYRLRSVRFN--NDRKYMVVTFNQSLLMGKSYVL 139
            ..::.|||:|::...:.|    ||. :....:..:.:..||  |:.:.:.::|..:|..|.. .|
Mouse    86 QVRQATNQIVMNCADIDI----ITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTG-TL 145

  Fly   140 SVEFGRPMTMDQRDGYFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHH 204
            .::|...:. |:..|::...|.. ...|..:.:|:.|.....|...|.:|||::||||::::...
Mouse   146 KIDFVGELN-DKMKGFYRSRYTT-PAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVP 208

  Fly   205 KRFQSYGNMKVQAVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCA 269
            |...:..||.|....|..:.::.|......||.:.|:|:||.|..::  :.:..|...|..|...
Mouse   209 KDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYD--FVETRSKDGVCVRVYT 271

  Fly   270 QSADVRATSFAAQMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLRE 334
            .........||.::|.:.|.|......|..||.|||.:.:.||...||||:|||.||...||:..
Mouse   272 PVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDP 336

  Fly   335 DGPMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDH-----------L 388
            ....|..:.....::.||:||.||.||:.|:.::.|||.||.|.:.:.|.|||           :
Mouse   337 KNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFV 401

  Fly   389 QSKMGRRILLRYRESSMMYESQVGGISLVPLSSNASLNAETQLYQKATSLTSMLIGFLGNETFYD 453
            .:...|...|...::|...|..||..|.|....:|.      .|.|..|:..||..::|::.|..
Mouse   402 SADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAI------SYSKGASVIRMLHDYIGDKDFKK 460

  Fly   454 GLQRHMWQNSF---GSSTPDLFWRSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLV------- 508
            |:  :|:...|   .::|.|| |.||:.||.:        .:.::|:|||.|.|:||:
Mouse   461 GM--NMYLTKFQQKNAATEDL-WESLESASGK--------PIAAVMNTWTKQMGFPLIYVEAEQV 514

  Fly   509 ---TVIRNGSEVFLKQGHALNRSSSHLWWIPLTYLIEGGSLSKNLKPKAWLSPNSHGIKLNDIVP 570
               .|::...:.|...| .........|.:|:|  |.........|.|..:......:.|.::.|
Mouse   515 EDDRVLKLSQKKFCASG-PYGGEDCPQWMVPIT--ISTSEDPNQAKLKILMDKPEMSVVLKNVKP 576

  Fly   571 RNQWILLNLQAVGYYRVNYDELTWQLL-------------ATTLFNDFRSINVLNRAQIVSDV-- 620
             :||:.|||..||:||..|.....:.|             ...|.||..|   |.||.|:|.|
Mouse   577 -DQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFS---LARAGIISTVEV 637

  Fly   621 -----LFLWNQDLLAWSTA---LNVLKYIIDE-DEYEPLMAFV----------VGW 657
                 .|:...:...||..   |.:|..::.. |.||.:..||          :||
Mouse   638 LKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGW 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	123/464 (27%)
		ERAP1_C	574..>652	CDD:338125	28/101 (28%)
		dnaA	630..>701	CDD:234667	11/42 (26%)
Npepps	NP_032968.2	Peptidase_M1	54..442	CDD:279741	110/405 (27%)
		M1_APN_2	62..505	CDD:189008	127/471 (27%)
		Substrate binding. /evidence=ECO:0000250	317..321		2/3 (67%)
		ERAP1_C	580..891	CDD:288671	31/117 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	727..731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920