DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7653 and anp-1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	750	Identity:	196/750 - (26%)
Similarity:	332/750 - (44%)	Gaps:	134/750 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EPRLPAKVKPFHYDIRLLTHL------ESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKK 99
            |.|||..|.|..|.:.:.|:|      ....|.::.|.|.|.::..|:       :.:||:.||.
Worm    83 ELRLPTSVSPISYQLTVKTYLPGYGYTADKNNLTFEGQVLIELNITKS-------IKKVSLNSKD 140

  Fly   100 ITL---FGETSNYRL--RSVRFNNDRK---YMVVTFN--QSLLMGKSYVLSVEFGRPMTMDQRDG 154
            :..   |.:.|:..:  :|:.|..|.|   :..:.||  :::....|..|.|.||.|:..|. .|
Worm   141 LNYTEEFIKKSSILVNGKSIAFTLDDKQSTHEKIFFNLDETVEPTTSATLKVAFGAPLRTDM-SG 204

  Fly   155 YFIRHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGN---MKVQ 216
            .:...|.|.|...|: .:|:.....:.|..:|.||||:.|||:.||:.|..:..:..|   .||:
Worm   205 LYQTTYTNSKGESKM-AAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPNKTVAVSNGIEDKVE 268

  Fly   217 AVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFAA 281
            ...|.     ::.|..:.||.:.::|||..::.|  .|::|.:.|.||||..::..:..:|.:|.
Worm   269 DGQPG-----FIISTFKPTPRMSSYLLAIFISEF--EYNEATTKSGVRFRVWSRPEEKNSTMYAV 326

  Fly   282 QMAPQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTL 346
            :...:.||:.::...::.||.|.|.:.:.||...||||:||:.||...||.........:|.:..
Worm   327 EAGVKCLEYYEKYYNISFPLPKQDMVALPDFSAGAMENWGLITYRESALLYDPRIYSGSQKRRVA 391

  Fly   347 ELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRE--------S 403
            .:||||:||.||.||:.:..::||||.||.|...:.|..|.:..  |.   :|.||        |
Worm   392 VVIAHELAHQWFGNLVTLKWWNDLWLNEGFATLVEYLGTDEISD--GN---MRMREWFTMDALWS 451

  Fly   404 SMMYESQVGGISLVPLSSNASLNAE------TQLYQKATSLTSMLIGFLGNETFYDG----LQRH 458
            ::..:|..   |..||:.......|      :..|.|..::.:|:...:|.|.|..|    |.||
Worm   452 ALAADSVA---STHPLTFKIDKAMEVLDSFDSVTYDKGGAVLAMVRKTIGEENFNTGINHYLTRH 513

  Fly   459 MWQN--------SFGSSTPDLFW--RSLQLASEREATFDKTWDVKSIMDTWTMQSGYPLVTVIR- 512
            .:.|        :.|...||...  :.::|            ::...||.||.|.||||:...|
Worm   514 QFDNADAGNLLTALGEKIPDSVMGPKGVKL------------NISEFMDPWTKQLGYPLLNASRI 566

  Fly   513 NGSEVFLKQ--------GHALNRSSSHLW---W-IPLTYLIEGGSLSKNLKPKAWLSPNSHGIKL 565
            |.:.:.::|        |....:.|:.:|   | :|:.|.:.|   |..|:.| |:       |.
Worm   567 NNTHIIVEQSRFKLLATGKEEEKYSNPVWGFKWDVPVWYQVVG---SSELEMK-WM-------KR 620

  Fly   566 ND--IVPRNQWILLNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDL 628
            |:  |:..::.:::|.::.|:||..|....|:.::..|..:....:...|.:::.|...|....|
Worm   621 NEPLIIKSDKNVIINAESNGFYRAGYSSGLWKEISEMLKENHEQFSPQTRVRLIDDSFALARAGL 685

  Fly   629 LAWSTALNVLKYIIDEDEYEPLMAFVVGWTNG---------FWGISTE----SSFNIAKWLGIAA 680
            |::|..||::.|:.:|.||.|       |:..         .:|.:.|    :.|.||......|
Worm   686 LSYSIPLNLITYLKNEKEYLP-------WSGAIAKIRELIDMYGSNPEKDIVNKFMIALAENAPA 743

  Fly   681 KWYAEFISYTF---DKFVVQDPNQN--LNSLDYPD 710
            :...:|:|..:   .||......|.  |||..:.|
Worm   744 RRSIDFVSKNYLDEKKFYEVGAAQQIILNSCGFGD 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	130/494 (26%)
		ERAP1_C	574..>652	CDD:338125	20/77 (26%)
		dnaA	630..>701	CDD:234667	19/86 (22%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	119/424 (28%)
		M1_APN_2	93..559	CDD:189008	134/501 (27%)
		ERAP1_C	632..964	CDD:288671	35/153 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020