DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7653 and Y42A5A.1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_505820.1	Gene:	Y42A5A.1 / 179536	WormBaseID:	WBGene00012776	Length:	1045	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	178/729 - (24%)
Similarity:	288/729 - (39%)	Gaps:	151/729 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 PFHYDIRLLTHLE-------SSANHSYTGIVKISIHAQKTTNQVVL-------HVGRVSIE---S 97
            |..|::.|...:.       .|.|.|..|.|:  :|........:|       |:|...:.   :
Worm   159 PLLYEVELKLFVPWRPTISFGSDNFSVKGHVR--VHFTSGGGSRILLHSDSKQHIGDCVVRDELN 221

  Fly    98 KKIT--LFGETSNYRLRSVRFNNDRKY---MVVTFNQSLLMGKSYVLSVEFGRPMTMDQRDGYFI 157
            :.||  |.|               |:|   :.:.....::.|.:|.|.|.|...:.::...|.|.
Worm   222 RNITVKLVG---------------RQYSQILDLNLETDMIHGMNYTLDVAFKSAINLNLAYGLFA 271

  Fly   158 RHYINWKTSEKIWYSVSHFNRNWIRNTMPSFDEPSLKATFNVTMGHHKRFQSYGNMKVQAVLPNR 222
            ..|.  ..:|..:...:....:..|...|..|.|.:||.|:..:.|.....|..||     :.|.
Worm   272 APYT--FENETRYVVATQLQISEARTVFPCIDVPDMKAQFDTVIIHPTGTTSIANM-----MENS 329

  Fly   223 EIQDYVWSV---HEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRT-CAQSADVRATSFAAQM 283
            ...|..|:.   |. ||.:.|:|.||||:::  .|.:..|...||.|. |..:..|.|......:
Worm   330 TKVDGEWTTTTFHR-TPPMSTYLFAFSVSDY--PYLETFSGRGVRSRVYCDPTKLVDAQLITKSI 391

  Fly   284 APQILEFLDRVLQVALPLEKIDQLVVDDFPTEAMENFGLVVYRSKHLLLREDGPMSKEKLQTLEL 348
            .| :|:|.:....:..||||:|.::|......||||:||:..|..:.|..|......:|....|:
Worm   392 GP-VLDFYEDYFGIPYPLEKLDVVIVPALSVTAMENWGLITIRQTNGLYTEGRFAISQKHDVQEI 455

  Fly   349 IAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYRESSMMYESQVGG 413
            :|||:||.||.||:.|..::||||.||.|......|||.|::     ...||.:||.  |||...
Worm   456 VAHELAHQWFGNLVTMKWWNDLWLNEGFATLISVRAVDFLEN-----TTWRYEDSSA--ESQCVA 513

  Fly   414 I------SLVPLSSNASLNAETQ--------LYQKATSLTSMLIGFLGNETFYDGLQRHMWQNSF 464
            :      |:.|:|...:.|.::.        :|:|:..:..|:...:..:.|..||:|.:  |:|
Worm   514 LRADQIDSISPVSGKKNSNFDSYMEIQGKAIIYKKSAIIIRMIERLVEEDIFRQGLKRFL--NTF 576

  Fly   465 ---GSSTPDLFWRSLQLASEREA---TFDKTWDVKSIMDTWTMQSGYPLVTVIR-NGSEVFLKQ- 521
               .:...||| ..|....:..|   ...:.:.:..:||||..|:.:|::.|.| .||.|.|:|
Worm   577 LYKNADHEDLF-NVLVYVHDSSAGGHLRGQNFSLSDVMDTWIRQAHFPVIHVNRKEGSLVTLRQE 640

  Fly   522 --GHA-LNRSSSHLWWIPLTY--LIEGGSLSKNLKPKA-WLSPNSHGIKLNDIVPR----NQWIL 576
              .|. .:.....:|.||:.|  .:.|       |.|. ||:         |..|:    ...::
Worm   641 KYEHVPRDEPEKQVWKIPIFYDDPVSG-------KHKVFWLT---------DTQPKVFDMGGLLV 689

  Fly   577 LNLQAVGYYRVNYDELTWQLLATTLFNDFRSINVLNRAQIVSDVLFLWNQDLLAWSTALNVLKYI 641
            ::...:.|.|:.||...:..:...|.:||..|...:|::::.|.|.:.....|.:....|:..|:
Worm   690 VDPHQLTYMRLRYDMEMYSDITMALMDDFTMIPTNSRSRLIDDTLAMAENGQLTYKVPFNLTMYM 754

  Fly   642 IDEDEYEPLMAFVV-------------GWTNGFWGISTESSFNIAKWLGIAAKWYAEFISYTFDK 693
            ..|..|.|...|..             ||:                   |..|:....:...|||
Worm   755 SREIAYRPFQTFSAYLDFFLPRMYIHEGWS-------------------IYKKYLELVVGIPFDK 800

  Fly   694 FVVQDPNQNLNSLD 707
            |       |...||
Worm   801 F-------NAEGLD 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	126/493 (26%)
		ERAP1_C	574..>652	CDD:338125	17/77 (22%)
		dnaA	630..>701	CDD:234667	14/83 (17%)
Y42A5A.1	NP_505820.1	Peptidase_M1	159..549	CDD:279741	111/424 (26%)
		M1_APN_2	181..623	CDD:189008	125/479 (26%)
		ERAP1_C	688..998	CDD:288671	29/146 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020