DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7653 and ltah-1.1

DIOPT Version :9

Sequence 1:	NP_001356886.1	Gene:	CG7653 / 34935	FlyBaseID:	FBgn0028935	Length:	710	Species:	Drosophila melanogaster
Sequence 2:	NP_001023056.1	Gene:	ltah-1.1 / 178176	WormBaseID:	WBGene00016589	Length:	609	Species:	Caenorhabditis elegans

Alignment Length:	708	Identity:	142/708 - (20%)
Similarity:	247/708 - (34%)	Gaps:	225/708 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PRLPA------KVKPFHYDIRLLTHLESSANHSYTGIVKISIHAQKTTNQVVLHVGRVSIESKKI 100
            ||.|:      :|...||.::.....|..   ...|.|.|::..::.|.::||....:|::|..:
Worm     6 PRDPSTAANYEQVTVSHYALKWKVDFEKK---HIAGDVSITLDVKQDTERIVLDTRDLSVQSVAL 67

  Fly   101 TLFGE--TSNYRLRSVRFNNDRKYMVVTFNQSLLMGKSYVLSVEFGRP--------MTMDQRDGY 155
            .|.||  .:.:.|..   |......:|...:||..|...||.:::...        :|.:|
Worm    68 NLNGEPKKAGFTLED---NQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQ---- 125

  Fly   156 FIRHYINWKTSEKIW-YSVSHFNRNWIRNTMPSFDEPSLKATFN----VTMGHHKRFQSYGNMKV 215
                     |::::. |..|.......|:.:|..|.||:|:|:.    |.:|......:.|....
Worm   126 ---------TTDRVAPYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGST 181

  Fly   216 QAVLPNREIQDYVWSVHEVTPTIPTHLLAFSVNNFNCRYSQAASLSPVRFRTCAQSADVRATSFA 280
            .:....|.|..:...|     :||::|||..|.:.     :...:|    ..||..|:      .
Worm   182 PSECGKRTIFSFKQPV-----SIPSYLLAIVVGHL-----ERKEIS----ERCAVWAE------P 226

  Fly   281 AQMAPQILEF--LDRVLQVALPLE------KIDQLVVD-DFPTEAMENFGLVVYRSKHLLLREDG 336
            :|......||  .:::|:||..:.      :.|.:|:. .||...|||..|.....  .||..|.
Worm   227 SQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITP--TLLAGDR 289

  Fly   337 PMSKEKLQTLELIAHEMAHMWFDNLLGMDSYSDLWLTEGLAGYFKSLAVDHLQSKMGRRILLRYR 401
            .:       :.:||||::|.|..||:...|:...||.||...:.:.    .:..||       |.
Worm   290 SL-------VNVIAHEISHSWTGNLVTNFSWEHFWLNEGFTVFLER----KIHGKM-------YG 336

  Fly   402 ESSMMYESQVGGISLVPLSSNASLNAE---TQL-----------------YQKATSLTSMLIGFL 446
            |....:||:.|....:..:.|.....:   |:|                 |:|.::|...:...|
Worm   337 ELERQFESESGYEEALVRTVNDVFGPDHEYTKLVQNLGNADPDDAFSSVPYEKGSALLFTIEQAL 401

  Fly   447 GNETFY-----DGLQRHMWQNSFGSSTPDLFWRSLQLASEREATFDKTWDVKSIMDT-----WTM 501
            |:.:.:     |.:|::.::.   .||.:  |        :|..:|...|.|.|:|.     |..
Worm   402 GDNSRFEQFLRDYIQKYAYKT---VSTEE--W--------KEYLYDSFTDKKVILDNIDWNLWLH 453

  Fly   502 QSGYPLVTVIRNGSEVFLKQGHALNRSSSHLWWIPLTYLIEGGSLSKNLKPK------------- 553
            ::|.|                             |              |||
Worm   454 KAGLP-----------------------------P--------------KPKYDSTPMQACKDLA 475

  Fly   554 -AWLSPNSHGIKLNDIVPR--NQWILLNLQAVGYYRVNYDELTWQLLATTLFND-------FRSI 608
             .|.:..|......::..:  |...|..|.||   |||          .|:|.|       ...:
Worm   476 AKWTTEGSEAPTDGEVFAKMSNSQKLAVLDAV---RVN----------KTMFGDRMPALTATYKL 527

  Fly   609 NVLNRAQIVSDVLFL-----WNQDL---LAWSTALNVLKYIIDEDEYEPLMAFVVGWT 658
            :....|::....|.|     |:..:   ||::.|:..:||.      :|:...:.||:
Worm   528 DQAKNAELKFSWLMLGLETKWSPIVDASLAFALAVGRMKYC------KPIYRSLFGWS 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7653	NP_001356886.1	M1_APN-Q_like	52..500	CDD:341064	106/501 (21%)
		ERAP1_C	574..>652	CDD:338125	20/92 (22%)
		dnaA	630..>701	CDD:234667	7/29 (24%)
ltah-1.1	NP_001023056.1	M1_LTA4H	8..453	CDD:189006	109/516 (21%)
ltah-1.1	NP_001023056.1	Leuk-A4-hydro_C	468..608	CDD:312599	25/131 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910